A5072644673- Advanced MRI Techniques and Applications
- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Cardiovascular Function and Risk Factors
- Muscle Physiology and Disorders
- Medical Imaging Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Congenital Heart Disease Studies
- Cardiac Imaging and Diagnostics
- Plant responses to water stress
- Plant Stress Responses and Tolerance
- Muscle activation and electromyography studies
- Cardiovascular Disease and Adiposity
- Transcranial Magnetic Stimulation Studies
- Cryospheric studies and observations
- Soil Geostatistics and Mapping
- Endometrial and Cervical Cancer Treatments
- Hydrology and Watershed Management Studies
- Coastal wetland ecosystem dynamics
University of California, Los Angeles
2018-2025
University of Chicago
2015-2016
Fort Hays State University
2014-2015
Background: Duchenne Muscular Dystrophy (DMD) is a prevalent fatal genetic disorder, and heart failure the leading cause of mortality. Peak left ventricular (LV) circumferential strain (Ecc), twist, circumferential-longitudinal shear angle (θCL) are promising biomarkers for improved early diagnosis incipient failure. Our goals were as follows: 1) to characterize spectrum functional rotational LV in boys with DMD compared healthy age-matched controls; 2) identify cardiomyopathy absence...
Abstract Purpose T 1 mapping is a widely used quantitative MRI technique, but its tissue‐specific values remain inconsistent across protocols, sites, and vendors. The ISMRM Reproducible Research Quantitative MR study groups jointly launched challenge to assess the reproducibility of well‐established inversion‐recovery using acquisition details from seminal paper on standardized phantom in human brains. Methods protocol Barral et al. (2010). Researchers collected data ISMRM/NIST and/or Data...
Purpose Cardiomyocyte organization and performance underlie cardiac function, but the in vivo mobility of these cells during contraction filling remains difficult to probe. Herein, a novel trigger delay (TD) scout sequence was used acquire high in-plane resolution (1.6 mm) Spin-Echo (SE) diffusion tensor imaging (cDTI) at three distinct phases. The objective characterize cardiomyocyte throughout cycle healthy volunteers. Materials methods Nine volunteers were imaged with cDTI phases (early...
Cardiovascular disease is the leading cause of death in patients with Duchenne muscular dystrophy (DMD)—a fatal X-linked genetic disorder. Late gadolinium enhancement (LGE) imaging current gold standard for detecting myocardial tissue remodeling, but it often a late finding. Current research aims to investigate cardiovascular magnetic resonance (CMR) biomarkers, including native (pre-contrast) T1 and extracellular volume (ECV) evaluate early on-set microstructural remodeling grade severity....
Purpose: For this study, we investigated the computer-extracted tumor phenotypes from diffusion weighted imaging, dynamic contrast-enhanced, and T2-weighted magnetic resonance imaging modalities on a dataset of malignant benign breast lesions. Methods: The IRB-approved, retrospectively-collected included 118 lesions with 105 13 benign. All images were acquired during clinical MRI at both 1.5T 3.0T magnet strength. Phenotypic categories extracted each modality size, shape, margin sharpness,...
Ethanol, a metabolic toxin, is produced by plants during anaerobic fermentation. Traditionally, it was hypothesized wetland plants, which are tolerant of conditions in sediments, might be those most ethanol toxicity. Even though does not typically accumulate to toxic levels field conditions, whether flooding tolerance related remains an open question. Therefore, we compared flood-tolerant and flood-sensitive species assess susceptibility exposure. Ten were compared; 4–10 replicate each grown...
Boudreau et al., (2023). Results of the ISMRM 2020 joint Reproducible Research & Quantitative MR study groups reproducibility challenge on phantom and human brain T1 mapping. NeuroLibre Preprints, 14, https://doi.org/10.55458/neurolibre.00014
Background Clinical management of boys with Duchenne muscular dystrophy (DMD) relies on in‐depth understanding cardiac involvement, but right ventricular (RV) structural and functional remodeling remains understudied. Purpose To evaluate several analysis methods identify the most reliable one to measure RV pre‐ postcontrast T1 (RV‐T1) characterize myocardial in DMD. Study Type Prospective. Population Boys DMD ( N = 27) age‐/sex‐matched healthy controls 17) from two sites. Field...
Purpose: For this study, we investigated quantitative radiomics of breast tumors on diffusion weighted imaging and dynamic contrast-enhanced MRIs in the task assessing prognostic status cancers. Methods: Our IRB-approved, retrospectively-collected dataset included 316 cancers with 235 ER+ 81 ER- cases. All images were acquired during clinical MRI incorporating dynamic-contrast diffusion-weighted MRI. Phenotypic categories extracted quantitatively from DCE-MRI tumor size, shape, margin...
Boudreau et al., (2024). Paper is not enough: Crowdsourcing the T1 mapping common ground via ISMRM reproducibility challenge. NeuroLibre Reproducible Preprints, 23, https://doi.org/10.55458/neurolibre.00023
A collaborative reproducibility challenge was launched to explore if an imaging protocol independently-implemented at multiple centers can reliably measure T1 using inversion recovery in a standardized quantitative MRI phantom (ISMRM/NIST). total of 19 submissions were accepted, totalling 41 mapping datasets. Errors relative the temperature-corrected reference values under 10% for range expected human brain vivo. All submitted data, code, pipelines, and scripts shared on open platforms.
Motivation: Duchenne muscular dystrophy (DMD) leads to pediatric cardiomyopathy. Pre-contrast T1 in DMD identifies myocardial remodeling, but it remains unclear if T1-Mapping biomarkers can detect longitudinal changes DMD. Goal(s): The objective was characterize progressive pre-contrast at 3T. Approach: Boys with and healthy controls underwent a 3T CMR exam that included standard functional mapping sequences. were examined two points (18 months apart). Results: capable of detecting boys 18...
Background: In boys with Duchenne muscular dystrophy (DMD), cardiomyopathy has become the primary cause of death. Although both positive late gadolinium enhancement (LGE) and reduced left ventricular ejection fraction (LVEF) are findings in a DMD cohort, LV end-systolic circumferential strain at middle wall (Ecc) serves as biomarker for detecting early impairment cardiac function associated DMD. However, Ecc derived from cine Displacement Encoding Stimulated Echoes (DENSE) not been...
Left ventricular (LV) peak mid-wall circumferential strain (E cc ) and twist are early biomarkers for evaluating the subtle highly variable onset progression of cardiomyopathy in pediatric subjects with Duchenne muscular dystrophy (DMD). Cine Displacement Encoding Stimulated Echoes (DENSE) has proven sensitive to changes E twist, but not been reported a DMD cohort. We show that free-breathing DENSE CMR at 3T provides reproducible middle-ventricular , radial rr ), measurements healthy boys...
Cardiac magnetic resonance (CMR) is an important tool to assess cardiac disease progression in boys with Duchenne muscular dystrophy (DMD), native (pre-contrast) myocardial T1-mapping considered a possible biomarker of fibrosis. Due its thin wall and highly trabeculated structure, the right ventricle (RV) remains understudied DMD despite pre-clinical evidence RV involvement. After determining most robust method obtaining RV-T1, we assessed hypothesis that RV-T1 distinguishes healthy controls...