A5055975481- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Neurological disorders and treatments
- Geomagnetism and Paleomagnetism Studies
- Neuroscience and Neuropharmacology Research
- Magnetic and Electromagnetic Effects
- Multiple Sclerosis Research Studies
- Diamond and Carbon-based Materials Research
- Characterization and Applications of Magnetic Nanoparticles
- High-pressure geophysics and materials
- Hemispheric Asymmetry in Neuroscience
- Atomic and Subatomic Physics Research
- Ultrasound and Hyperthermia Applications
- Metal and Thin Film Mechanics
- Nanoparticle-Based Drug Delivery
- Lanthanide and Transition Metal Complexes
- Congenital heart defects research
- Sleep and Wakefulness Research
- Brain Tumor Detection and Classification
- Primate Behavior and Ecology
- Electron Spin Resonance Studies
University of Trento
2022-2025
Center for Neuroscience and Cognitive Systems
2017-2025
University of Turin
2025
Hôpital Maisonneuve-Rosemont
2023-2024
University of Verona
2009-2021
Italian Institute of Technology
2017-2020
National Interuniversity Consortium of Materials Science and Technology
2014-2018
Centre for Movement Disorders
2015
University of Cagliari
2015
University of Florence
2015
A new approach for the preparation of carbohydrate-coated magnetic nanoparticles is reported. In a first step, we show that pH-driven assembly-disassembly natural process occurs in apoferritin protein effective encapsulation maghemite different sizes: 4 and 6 nm. second demonstrate presence functional amine groups outer shell allows functionalization with two carbohydrates, N-acetyl-d-glucosamine d-mannose. High-resolution electron microscopy (HREM), high angle annular dark field scanning...
A facile method for the synthesis of water dispersible Er(3+)/Yb(3+) and Tm(3+)/Yb(3+) doped upconverting GdF(3) nanoparticles is reported. Strong upconversion emissions are observed in red (for Er/Yb doped) near-infrared Tm/Yb regions upon laser excitation at 980 nm. The PEG coating ensures a good dispersion system reduces radiationless de-excitation excited states Er(3+) Tm(3+) ions by molecules. r(2) relaxivity values quite high with respect to common T(2)-relaxing agents (22.6 ± 3.4...
Cortical reorganization occurring in multiple sclerosis (MS) patients is thought to play a key role limiting the effect of structural tissue damage. Conversely, its exhaustion may contribute irreversible disability that accumulates with disease progression. Several aspects MS-related cortical reorganization, including overall functional and likely modulation by therapies, still remain be elucidated. The aim this work was assess extent brain structural/pathological correlates Dark Agouti rats...
Magnetic nanoparticles (MNPs) are capable of generate heating power under the influence alternating magnetic fields (AMF); this behaviour recently opened new scenarios for advanced biomedical applications, mainly as promising tumor therapies. In paper we have tested called magnetosomes (MNs): a class MNPs naturally produced by magnetotactic bacteria. We extracted MNs from Magnetospirillum gryphiswaldense strain MSR-1 and interaction with cellular elements anti-neoplastic activity both in...
Abstract The anterior insular cortex plays a key role in the representation of interoceptive effects drug and natural rewards their integration with attention, executive function, emotions, making it potential target region for intervention to control appetitive behaviors. Here, we investigated chemogenetic stimulation or inhibition insula on alcohol sucrose consumption. Excitatory inhibitory designer receptors (DREADDs) were expressed alcohol-preferring rats by means adenovirus-mediated...
Abstract Purpose T 1 mapping is a widely used quantitative MRI technique, but its tissue‐specific values remain inconsistent across protocols, sites, and vendors. The ISMRM Reproducible Research Quantitative MR study groups jointly launched challenge to assess the reproducibility of well‐established inversion‐recovery using acquisition details from seminal paper on standardized phantom in human brains. Methods protocol Barral et al. (2010). Researchers collected data ISMRM/NIST and/or Data...
ABSTRACT Functional brain fingerprinting has emerged as an influential tool to quantify reliability in neuroimaging studies and identify cognitive biomarkers both healthy clinical populations. Recent have revealed that fingerprints reside the timescale‐specific functional connectivity of particular regions. However, impact acquisition's temporal resolution on remains unclear. In this study, we examine for first time derived from resting‐state MRI (rs‐fMRI) with different whole‐brain...
ABSTRACT Recent studies have reported social cognitive deficits, particularly in emotional processing, Parkinson's disease (PD). However, a comprehensive characterization of these deficits and their underlying neural correlates remains elusive. Therefore, this study aims to investigate the association between recognition complex mental states structural/functional brain changes non‐demented PD individuals. To reach aim, 24 participants underwent clinical assessment, neuropsychological...
We studied the spin depolarization of ensembles nitrogen-vacancy (NV) centers in nitrogen-rich single crystal diamonds. found a strong dependence evolution polarized state dark on concentration NV centers. At low excitation power, we observed simple exponential decay profile low-density regime and paradoxical inverted high-density regime. higher complex behavior, with an initial sharp rise luminescence signal after preparation pulse followed by slower decay. Magnetic field laser...
Sensing of a few unpaired electron spins, such as in metal ions and radicals, is useful but difficult task nanoscale physics, biology, chemistry. Single negatively charged nitrogen-vacancy (NV-) centers diamond offer high sensitivity spatial resolution the optical detection weak magnetic fields produced by spin bath often require long acquisition times on order seconds. Here, we present an approach based coupled charge dynamics dense NV ensembles strongly fluorescent nanodiamonds (NDs) to...
We investigated the theranostic properties of magnetosomes (MNs) extracted from magnetotactic bacteria, promising for nanomedicine applications. Besides a physico‐chemical characterization, their potentiality as mediators magnetic fluid hyperthermia and contrast agents resonance imaging, both in vitro vivo , are here singled out. The MNs, constituted by magnetite nanocrystals arranged chains, show superparamagnetic behaviour clear evidence Verwey transition, signature presence. phospholipid...
Magnetic fluid hyperthermia (MFH) with chemically synthesized nanoparticles is currently used in clinical trials as it destroys tumor cells an extremely localized deposition of thermal energy. In this paper, we investigated MFH protocol based on magnetic naturally produced by magnetotactic bacteria: magnetosomes. The efficacy such tested a xenograft model glioblastoma. Mice receive single intratumoral injection magnetosomes, and they are exposed three times week to alternating field...
Nitrogen-vacancy (NV) centers in diamond have attracted considerable interest sensing of weak magnetic fields, such as those created by biological systems. Detecting feeble signals requires near-surface NV centers, to reduce the distance between NVs and sources. Moreover, dense ensembles are highly desirable measurement time. However, robust charge-state switching is often observed these systems, resulting a complex interplay charge spin dynamics that can attainable level polarization,...
BACKGROUND AND OBJECTIVES: Precise mapping of functional networks in patients with brain tumor is essential for tailoring personalized treatment strategies. Resting-state MRI (rs-fMRI) offers an alternative to task-based fMRI, capable capturing multiple within a single acquisition, without necessitating task engagement. This study demonstrates strong concordance between preoperative rs-fMRI maps and the gold standard intraoperative direct electric stimulation (DES) during awake surgery....
New long-circulating maghemite nanoparticles of 4 and 6 nm, coated with an apoferritin protein capsid, exhibit useful properties to act as magnetic resonance imaging (MRI) contrast agents. A full in vivo study the so-called apomaghemites reveals that their long-term MRI are better than those a standard superparamagnetic iron oxide (SPIO) widely used biomedical applications. The biodistribution SPIO was investigated by mice at two different concentrations, 2.5 mg Fe·kg(-1), over 60 days....
The idea that sensory stimulation to the embryo (in utero or in ovo) may be crucial for brain development is widespread. Unfortunately, up now evidence was only indirect because mapping of embryonic activity vivo challenging. Here, we applied first time manganese enhanced magnetic resonance imaging (MEMRI), a functional method, eggs domestic chicks. We revealed light-induced asymmetry by comparing were stimulated light maintained darkness. Our protocol paves way investigation effects variety...
ABSTRACT In opioid use disorder (OUD) patients, a decrease in brain grey matter volume (GMV) has been reported. It is unclear whether this the consequence of prolonged exposure to opioids or predisposing causal factor OUD development. To investigate this, we conducted structural MRI longitudinal study NIH Heterogeneous Stock rats exposed heroin self-administration and age-matched naïve controls housed same controlled environment. Structural scans were acquired before (MRI 1 ) after 2 period...
In activation-induced manganese-enhanced MRI (AIM-MRI) experiments, differential accumulation of Mn in activated and silent brain areas is generally assessed using T(1)-weighted images quantified by the enhancement signal intensity (SI), calculated with reference to SI before administration or regions unaffected specific stimulus. However, can be unreliable when animals are removed from reinserted into magnet. We have developed an experimental protocol based on repeated intraperitoneal...
Abstract A few studies have reported aberrant functional connectivity in alcoholic patients, but the specific neural circuits involved remain unknown. Moreover, it is unclear whether these alterations can be reversed upon treatment. Here, we used MRI to study resting state rats following chronic intermittent exposure ethanol. Further, evaluated effects of SB‐277011‐a, a selective dopamine D3 receptor antagonist, known decrease ethanol consumption. Alcohol‐dependent and control ( N = 13/14...