A5082312617- Nanoparticle-Based Drug Delivery
- Characterization and Applications of Magnetic Nanoparticles
- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- Radiation Therapy and Dosimetry
- Graphene and Nanomaterials Applications
- Radiation Detection and Scintillator Technologies
- Advanced Radiotherapy Techniques
- Endoplasmic Reticulum Stress and Disease
- Pancreatic function and diabetes
- Lanthanide and Transition Metal Complexes
- Laser-Ablation Synthesis of Nanoparticles
- Erythrocyte Function and Pathophysiology
- Prostate Cancer Treatment and Research
- Cancer, Hypoxia, and Metabolism
- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Iron oxide chemistry and applications
- Carbon Nanotubes in Composites
- Bone Metabolism and Diseases
- Neuropeptides and Animal Physiology
- Blood properties and coagulation
- Body Contouring and Surgery
- Peptidase Inhibition and Analysis
- Mesenchymal stem cell research
Vita-Salute San Raffaele University
2023-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2023-2025
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2023-2024
University of Verona
2017-2022
Lanthanide-activated fluoride-based nanostructures are extremely interesting multifunctional tools for many modern applications in nanomedicine, e.g., bioimaging, sensing, drug delivery, and photodynamic therapy. Importantly, environmental-friendly preparations using a green chemistry approach, as hydrothermal synthesis route, nowadays highly desirable to obtain colloidal nanoparticles, directly dispersible hydrophilic media, physiological solution. The nanomaterials under investigation new...
Minibeam radiotherapy (MBRT) uses small parallel beams of radiation to create a highly modulated dose pattern. The aim this study is develop an optical radioluminescence imaging (RLI) approach perform real-time measurement for MBRT. MBRT was delivered using image-guided animal irradiator equipped with custom collimator. Five slabs plastic scintillators thicknesses 0.5, 1, 2, 3 and 10 mm were placed on top mouse phantom, localize measure the dose. A thin film (Gd measured peak valley ratio...
Choline kinase α1 (ChoKα1) has become an excellent antitumor target. Among all the inhibitors synthetized, new compound Ff35 shows capacity to inhibit ChoKα1 activity. However, soluble is also capable of inhibiting choline uptake, making inhibitor not selective for ChoKα1. In this study, we designed a protocol with aim disentangling whether biological action due inhibition enzyme and/or uptake. Moreover, offer alternative avoid uptake caused by Ff35, since coupling novel biomimetic magnetic...
Autologous fat grafting is a surgical technique in which adipose tissue transferred from one area of the body to another, order reconstruct or regenerate damaged injured tissues. Before reinjection, needs be purified blood and cellular debris avoid inflammation preserve graft viability. To perform this purification, different enzymatic mechanical methods can used. In study, we characterized vitro product closed automatic device based on disaggregation, named Rigenera®, focusing two sites...
Magnetococcus marinus magnetosome-associated protein MamC, expressed as recombinant, has been proven to mediate the formation of novel biomimetic magnetic nanoparticles (BMNPs) that are successful drug nanocarriers for targeted chemotherapy and hyperthermia agents. These BMNPs present several advantages over inorganic nanoparticles, such larger sizes allow former have moment per particle, an isoelectric point at acidic pH values, which allows both stable functionalization physiological value...
To elucidate whether different cytokinetic features (i.e., presence or absence of mitotic activity) may influence cell uptake and distribution nanocarriers, in vitro tests on liposomes, mesoporous silica nanoparticles, poly(lactide-co-glycolide) nanoparticles nanohydrogels were carried out C2C12 murine muscle cells either able to proliferate as myoblasts (cycling cells) terminally differentiate into myotubes (noncycling cells).Cell intracellular fate investigated by confocal fluorescence...
In this work the effect of combining ultrasound (US) hyperthermia (HT) with radiotherapy (RT) was investigated. The treatment applied to a GBM xenograft nude mouse model obtained by injecting $$2 \times 10^{6}$$ U87 luc+ cells. combined group received 6 Gy and HT at $$43^\circ$$ for 8 min. field generated closed-loop computationally controlled system, consisting High Intensity Focused Ultrasound (HIFU) transducer centre frequency 3.57 MHz, power amplifier, function generator MATLAB...
This paper reports a comprehensive investigation of magnetic nanoparticle (MNP), named M55, which belongs to class innovative doped ferrite nanomaterials, characterized by self-limiting temperature. M55 is obtained from M48, an MNP previously described our group, implementing additional purification step in the synthesis. after citrate and glucose coating, G-M55. The present study aimed demonstrate properties G-M55 as diagnostic contrast agent for MRI particle imaging (MPI), antitumoral...
During the last few years, for therapeutic purposes in oncology, considerable attention has been focused on a method called magnetic fluid hyperthermia (MFH) based local heating of tumor cells.In this paper, an innovative, promising nanomaterial, M48 composed iron oxide-based phases tested.M48 shows self-regulating temperature due to observable second order phase transition from ferromagnetic paramagnetic state.A specific hydrophilic coating both citrate ions and glucose molecules allows...