A5008655895- Trypanosoma species research and implications
- Natural Compound Pharmacology Studies
- Sleep and Wakefulness Research
- Cervical Cancer and HPV Research
- Mesenchymal stem cell research
- Cancer, Hypoxia, and Metabolism
- Ethnobotanical and Medicinal Plants Studies
- Circadian rhythm and melatonin
- COVID-19 and Mental Health
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Metabolism, Diabetes, and Cancer
- Carbohydrate Chemistry and Synthesis
- Biochemical effects in animals
- Computational Drug Discovery Methods
- Chronic Lymphocytic Leukemia Research
- Cancer-related Molecular Pathways
- Global Cancer Incidence and Screening
- Sleep and related disorders
- Phytochemistry and Biological Activities
- Natural Antidiabetic Agents Studies
- Pharmacological Effects of Natural Compounds
- Cholesterol and Lipid Metabolism
- Calcium signaling and nucleotide metabolism
- bioluminescence and chemiluminescence research
Université de Yaoundé I
2009-2024
Institute for Sustainable Development
2020-2024
University of Ngaoundéré
2018-2022
University of Maroua
2022
South African Brain Research Institute
2020-2021
University of Verona
2011-2020
Qassim University
2012-2017
Office of Basic Energy Sciences
2012
Central Hospital of Yaoundé
2012
Background The timing of Trypanosoma brucei entry into the brain parenchyma to initiate second, meningoencephalitic stage human African trypanosomiasis or sleeping sickness is currently debated and even parasite invasion neuropil has been recently questioned. Furthermore, relationship between neurological features disease are unclear, despite important diagnostic therapeutic implications. Methodology Using a rat model chronic infection we determined T-cell infiltration its correlation with...
Estrogen deficiency is linked to changes in several physiological processes, but the extent which it associates with cognitive menopause context controversial.We evaluated impact of ovariectomy on memory processes and normal exploratory behavior Wistar rats.Young adult rats (4-6 months) were either ovariectomized (OVX group) (N = 10), sham operated or untouched (naïve controls) 8). Afterwards, they monitored for 12 weeks during their functions at first week (S1), second (S2), every 3 (S5,...
Abstract Background Cerebral malaria is a rapidly developing encephalopathy caused by the apicomplexan parasite Plasmodium falciparum . Drugs currently in use are associated with poor outcome an increasing number of cases and new drugs urgently needed. The potential medicinal plant Azadirachta indica (Neem) for treatment experimental cerebral was evaluated mice. Methods Experimental induced mice infection berghei ANKA. Infected were administered ethanolic extract at doses 300, 500, or 1000...
Background Human African trypanosomiasis (HAT) or sleeping sickness leads to a complex neuropsychiatric syndrome with characteristic sleep alterations. Current division into first, hemolymphatic stage and second, meningoencephalitic is primarily based on the detection of white blood cells and/or trypanosomes in cerebrospinal fluid. The validity this criterion is, however, debated, novel laboratory biomarkers are under study. Objective clinical HAT evaluation monitoring therefore needed....
Since March 2020, the Cameroonian government implemented nationwide measures to stall COVID-19 transmission. However, little is known about how well these unprecedented are being observed as pandemic evolves. We conducted a six-month online survey assess preventive behaviour of adults during outbreak. A five-point adherence score was constructed based on self-reported observance following measures: physical distancing, face mask use, hand hygiene, not touching one’s face, and covering mouth...
To assess the putative diuretic and antioxidant properties of Cassia occidentalis (C. occidentalis) leaves' aqueous extract.Adult rats were administered with C. leaves extract acutely (24 h) subchronically (7 d), at doses 80, 160, 240, 320, 400 mg/kg (per os). Negative control group received only an equivalent volume distilled water, while two positive groups drugs furosemide (20 mg/kg, ip.) hydrochlorothiazide (HCTZ) ip.). Urinary elimination electrolytes in response to treatments was...
Human African trypanosomiasis (HAT), or sleeping sickness, is a severe disease caused by Trypanosoma brucei (T.b.). The hallmark sleep alterations. Brain involvement in HAT crucial pathogenetic step for diagnosis and therapy. In this study, rat model of was used to assess changes sleep-wake, rest-activity, body temperature rhythms the time window previously shown as brain parenchyma invasion T.b. determine potential biomarkers event. Chronic radiotelemetric monitoring Sprague-Dawley rats...
Garcinia kola (G. kola), is a plant characterized by its hypoglycemic properties. We recently reported our findings on the extracts of G. kola, in which we found that it prevented loss inflammation-sensible neuronal populations streptozotocin (STZ)-induced rat models type 1 diabetes mellitus (T1DM). In present study assessed effect bioactive compounds extracted successively with water, hexane, methylene chloride, ethyl acetate, and butanol. through analyzing biochemical markers oxidative...
Background . Adansonia digitata is a plant used against cardiovascular disorders in African folk medicine. We assessed the effects of aqueous extract its stem bark on development hypertension L‐NAME‐induced hypertensive rats. Methods The animals were administered L‐NAME once daily for 3 weeks (25 mg/kg, i.p.), concomitantly with A. (100 and 200 p.o.) or captopril (20 p.o.). Then, hemodynamic electrocardiographic parameters, oxidative stress markers, lipid profile blood heart, aorta, kidney...
Human African trypanosomiasis (HAT) is a fatal if untreated fly-borne neuroinflammatory disease caused by protozoa of the species Trypanosoma brucei ( T.b. ). The increasing trend HAT cases has been reversed, but according to WHO experts, new epidemics this could appear. In addition, still considerable burden for life quality and economy in 36 sub-Saharan Africa countries with 15–20 million persons at risk. Following joined initiatives private partners, fight against was re-engaged,...