A5016134012- Neuroscience and Neuropharmacology Research
- Sleep and Wakefulness Research
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Circadian rhythm and melatonin
- Neuroinflammation and Neurodegeneration Mechanisms
- Visual perception and processing mechanisms
- Sleep and related disorders
- EEG and Brain-Computer Interfaces
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neural Engineering
- Neural and Behavioral Psychology Studies
- Nitric Oxide and Endothelin Effects
- Epilepsy research and treatment
- Functional Brain Connectivity Studies
- Photoreceptor and optogenetics research
- Tryptophan and brain disorders
- Neuroscience of respiration and sleep
- Neonatal and fetal brain pathology
- Biochemical Analysis and Sensing Techniques
- Quantum Dots Synthesis And Properties
- Adipose Tissue and Metabolism
- Erythrocyte Function and Pathophysiology
- Receptor Mechanisms and Signaling
- Infant Health and Development
University of Verona
2013-2024
Leipzig University
2016
National Institute for Astrophysics
2007-2011
Istituti Fisioterapici Ospitalieri
2002-2011
National Institute of Mental Health
1997-1999
University of Siena
1977
University of Florence
1977
Significance Influenza A virus infections are risk factors for narcolepsy, a disease in which autoimmunity has been implicated. We tested experimentally whether influenza could be causally related to narcolepsy. found that mice infected with H1N1 strain developed over time sleep–wake changes described murine models of narcolepsy and patients. In the brain, orexin/hypocretin-producing neurons, destroyed human other cells distributed sleep–wake-regulating neuronal network. The findings,...
Biological rhythms, and especially the sleep/wake cycle, are frequently disrupted during senescence. This draws attention to study of aging-related changes in hypothalamic suprachiasmatic nucleus (SCN), master circadian pacemaker. The authors here compared SCN young old mice, analyzing presynaptic terminals, including gamma-aminobutyric acid (GABA)ergic network, molecules related regulation GABA, main neurotransmitter neurons. Transcripts α3 subunit GABA A receptor GABA-synthesizing enzyme...
Activation of the nuclear factor κB/c-Rel can increase neuronal resilience to pathological noxae by regulating expression pro-survival manganese superoxide dismutase (MnSOD, now known as SOD2) and Bcl-xL genes. We show here that c-Rel-deficient (c-rel(-/-)) mice developed a Parkinson's disease-like neuropathology with ageing. At 18 months age, c-rel(-/-) exhibited significant loss dopaminergic neurons in substantia nigra pars compacta, assessed tyrosine hydroxylase-immunoreactivity Nissl...
Abstract Recent findings indicate that fingolimod, the first oral drug approved for treatment of multiple sclerosis ( MS ), acts as a direct inhibitor histone deacetylases HDAC s) and enhances production brain‐derived neurotrophic factor BDNF ) in CNS . Both mechanisms are relevant to pathophysiology major depression. We examined antidepressant activity fingolimod mice subjected chronic unpredictable stress CUS model reactive depression endowed with face pharmacological validity. Chronic (3...
Clinical and experimental studies indicate that muscarinic acetylcholine receptors are potential pharmacological targets for the treatment of neurological diseases. Although these have been described in human, bovine rat cerebral microvascular tissue, a subtype functional characterization mouse brain endothelium is lacking. Here, we show all (M1-M5) expressed endothelial cells. The mRNA expression M2, M3, M5 correlates with their respective protein abundance, but mismatch exists M1 M4 versus...
Abstract Chorea-Acanthocytosis (ChAc) is a devastating, little understood, and currently untreatable neurodegenerative disease caused by VPS13A mutations. Based on our recent demonstration that accumulation of activated Lyn tyrosine kinase key pathophysiological event in human ChAc cells, we took advantage Vps13a −/− mice, which phenocopied ChAc. Using proteomic approach, found active Lyn, γ-synuclein phospho-tau proteins basal ganglia secondary to impaired autophagy leading...
A bulk of data suggest that the gut microbiota plays a role in broad range diseases, including those affecting central nervous system. Recently, significant differences intestinal patients with epilepsy, compared to healthy volunteers, have been reported an observational study. However, active pathogenesis through so-called "gut-brain axis," has yet be demonstrated. In this study, we evaluated direct impact transplanted from epileptic animals recipient animals, clarify whether epilepsy can...
Abstract Objective Glutamate‐gated N ‐methyl‐ d ‐aspartate receptors ( NMDAR s) are instrumental to brain development and functioning. Defects in the GRIN 2A gene, encoding GluN2A subunit of s, cause slow‐wave sleep SWS )‐related disorders epilepsy‐aphasia spectrum EAS ). The as‐yet poorly understood developmental sequence early ‐related phenotypes, role GluN2A‐containing s associated electroencephalographic EEG ) activity patterns, were investigated Grin2a knockout KO mice. Methods Early...
The metallic impregnation invented by Camillo Golgi in 1873 has allowed the visualization of individual neurons their entirety, leading to a breakthrough knowledge on structure nervous system. Professor Histology and General Pathology, worked for decades at University Pavia, very active laboratory. Unfortunately, most Golgi's histological preparations are lost. present contribution provides an account original slides system from laboratory available nowadays Museum Historical Pavia....
Directing attention to a behaviorally relevant visual stimulus can overcome the distracting effects of other nearby stimuli. Correspondingly, physiological studies indicate that serves filter stimuli from receptive fields (RFs) in several extrastriate areas. Moreover, recent study demonstrated lesions areas V4 and TEO produce impairments attentional filtering. A critical remaining question concerns why ventral stream cause filtering impairments. To address this question, we tested restricted...
Biological rhythms are frequently disturbed with advancing age, and aging-related changes of glia in the hypothalamic suprachiasmatic nucleus (SCN), master circadian pacemaker, require special attention. In particular, astrocytes contribute to SCN function, aging is associated increased inflammatory activity brain, which microglia could be especially implicated. On this basis, we investigated young old mice glial transcripts cell features, response a central challenge. Quantitative real-time...
Increased cytokine expression contributes to the pathogenesis of cancer anorexia?cachexia syndrome. Carnitine may reduce inflammation in chronic diseases. We tested effects L-propionylcarnitine (PC group) or saline (C on food intake (FI), body composition, and inflammatory status MCA-sarcoma-bearing rats. On tumor appearance, rats were randomly assigned daily i.p. injection (250 mg/kgBW/d; n = 8) (equal volume; 8). FI fat-free mass wasting improved PC only (p < .01 vs. controls). Cytokines?...
The distribution of neuronal elements that express nitric oxide synthase (NOS), the synthetic enzyme free radical oxide, was investigated in adult and developing rat thalamus by means NADPH-diaphorase (NADPH-d) histochemistry, which is a marker NOS. Immunocytochemistry also used to confirm equivalence between histochemical pattern staining expression NOS isoform. In thalamus, NADPH-d-positive NOS-immunoreactive perikarya were selectively concentrated along midline (in paraventricular,...