Background Group B Streptococcus (GBS), also known as agalactiae, is a Gram-positive bacterium for its ability to colonise the vaginal and rectal areas of mother leading cause neonatal mortality morbidity. This study aimed at determining prevalence, associated risk factors antimicrobial susceptibility GBS colonisation among pregnant women attending antenatal care (ANC) Dschang District Hospital. Methods hospital-based cross-sectional used multistage sampling method recruit total 621...

Abstract Background Previous study showed that the aqueous extract of stem bark Cinnamomum zeylanicum possesses antihypertensive and vasodilatory properties. The present work investigates acute chronic effects methanol (MECZ) in L-NAME-induced hypertensive rats. Methods MECZ (5, 10 20 mg/kg) administered intravenously were evaluated rats which arterial hypertension has been induced by intravenous administration L-NAME (20 mg/kg). For effects, animals treated with (40 mg/kg/day) plus vehicle...

Dissotis thollonii Cogn. (Melastomataceae) is a tropical plant widely used in traditional Cameroonian medicine to relieve and treat many pathologies. It widespread the western region where it typhoid fever, gastrointestinal disorders, inflammatory diseases. The purpose of this study scientifically demonstrate anti-inflammatory antiarthritic properties aqueous ethanolic extracts leaves thollonii. were evaluated vitro by inhibition tests for cyclooxygenase, 5-lipoxygenase, protein...

Among the most exploited species in Cameroon, Alstonia boonei is widely used African medicine for relief of several pathologies including gastrointestinal disorders. This study was conducted order to assess effects aqueous and methanol stem‐bark extracts on DSS‐ (dextran sodium sulfate‐) induced intestinal colitis determine its antioxidant potential. The classes secondary metabolites present these were determined by chemical screening. production TNF‐ α , IL‐6, IL‐1 β PGE2 performed vitro...

Nephropathies and especially nephrotoxicity have become one of the serious causes life-threatening conditions because intensive exposure to xenobiotic whether by environmental pollution or drug abuse. The present study was undertaken assess protective effects Cinnamomum zeylanicum stem bark aqueous extract (AECZ) on gentamicin-induced nephrotoxicity. AECZ prepared maceration in water tested orally at doses 200 400 mg/kg/day prevent nephropathies male Wistar rats. Gentamicin (100 mg/kg/day)...

Background . Adansonia digitata is a plant used against cardiovascular disorders in African folk medicine. We assessed the effects of aqueous extract its stem bark on development hypertension L‐NAME‐induced hypertensive rats. Methods The animals were administered L‐NAME once daily for 3 weeks (25 mg/kg, i.p.), concomitantly with A. (100 and 200 p.o.) or captopril (20 p.o.). Then, hemodynamic electrocardiographic parameters, oxidative stress markers, lipid profile blood heart, aorta, kidney...

Combretum fragrans (Combretaceae) is a Cameroonian medicinal plant containing various secondary metabolites and traditionally used for the treatment of several pathologies. Two cycloartane-type triterpenes, Combretin A B, were isolated from this plant. This study was aimed at evaluating anti-inflammatory, antioxidant, anticolitis effects these compounds. In vitro anti-inflammatory properties evaluated by inhibition cyclooxygenase, 5-lipoxygenase, denaturation protein; antioxidant assessed...

Abstract Background : The goal of the study was to determine antidiabetic mechanisms and antioxidant effects aqueous (decoction maceration) methanol extracts from stem bark Ceiba pentandra . Methods These were tested in vitro on glucose uptake by skeletal muscles liver slices release slices. activities C. investigated at concentrations ranging 1 300 µg/mL 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydrogen peroxide (H 2 O )-induced hemolysis, H -induced brain lipid peroxidation, hydroxyl (˙OH)...

Vitex cienkowskii stem-bark is used in Cameroonian traditional medicine to treat cardiovascular diseases including hypertension. In previous studies, the methanol/methylene chloride extract of (MMVC) showed a preventive activity L-NAME-induced hypertension and improved blood pressure spontaneously hypertensive rats. The present study investigated curative effects rats (LNHR). Hypertension was induced by oral administration L-NAME (40 mg/kg/day) for 28 days. animals were divided into 2...

Abstract The present study investigated the effects of Gmelina arborea hexane leaves extract on markers oxidative stress and its vasorelaxant isolated rat aorta, in order to postulate possible mechanisms involved antihypertensive properties plant. To evaluate antioxidant extract, rats were randomly divided into four groups five each. With exception group receiving Tween (2.5%), other treated either with NaCl (900mg/kg/day) alone, combined vitamin C (5mg/kg/day) or (150mg/kg/day). At end...

The greatest common and devastating complication of diabetes is painful neuropathy that can cause hyperalgesia allodynia. It disturb psychosocial functioning by increasing levels anxiety depression. This work was designed to evaluate the antihyperalgesic, antidepressant, anxiolytic-like effects aqueous methanol extracts Nauclea pobeguinii stem-bark in diabetic induced streptozotocin mice. Diabetic mice intraperitoneal administration 200 mg/kg (STZ) provoke hyperglycemia. at doses 150 300...

In traditional Cameroonian medicine, to relieve many inflammations, parts of Vernonia guineensis, are very widely used. This study considered the evaluation acute toxicity and anti-inflammatory properties hydroethanolic extract roots guineensis. an study, 250, 2500, 5000 mg/kg were administered orally mice in a single dose, general behavior, adverse effects, mortality monitored. vitro vivo tests performed, then histological, serum, hematological, oxidative stress parameters have been...

Distemonanthus benthamianus (Caesalpiniaceae) is a plant from the Cameroon pharmacopoeia very widely used in treatment of many pathologies among which are gastrointestinal disorders. The main purpose this study was to assess healing properties gastric ulcer methanolic extract and its mechanisms action. ulcers (chronic model induced by ethanol indomethacin) were evaluated vivo adult male rats, while action vitro anti-inflammatory assay (protein denaturation, cyclooxygenase, lipoxygenase...

Arterial hypertension (AHT) is a leading cardiovascular disease, with high negative impact on the quality of life. Crinum zeylanicum (C. zeylanicum) leaves extract used in West region Cameroon to treat AHT and heart problems. This study aimed investigate antihypertensive effect C. Nω-nitro-L‐arginine methyl ester- (L‐NAME-) induced hypertensive rats. The aqueous (LAE) was obtained by lyophilizing juice triturated fresh leaves. methanol (LME) prepared maceration dried further partitioned...

The present study was undertaken to investigate the cardiovascular and in vitro antioxidant activities of methanol extract stem bark Erythrina senegalensis (EMES), a plant used traditionally Cameroon against arterial hypertension. effects EMES (11-44 mg/kg) were evaluated vivo on normotensive rat blood pressure rabbit’s electrocardiogram (5.5- 55 while (10-10 - 1 mg/ml) myocardial contractile performance isolated heart. (1-1000 µg/ml) investigated 1,1-diphenyl-2-picrylhydrazyl (DPPH),...

Objective: To evaluate spasmolytic mechanisms of aqueous and methanolic extracts from Distemonanthus benthamianus trunk-bark.Methods: Spasmolytic activities were evaluated in vitro on spontaneous potassium chloride-induced jejunum contractions, or against cholinergic [acetylcholine (0.3 μmol/L)] stimulations. High performance liquid chromatography analysis both was performed reference to standard compounds.Results: Extracts developed concentration-dependent inhibitory activities. The...

The aqueous and methanolic extracts of Rumex bequaertii leaves were investigated for their ability to prevent treated ulceration the gastric mucosa in animal models.For this, adult male rats three four months old weighing on average 180 g used both tests. tested orally at doses 125, 250 500 mg/kg, ulcerations experimentally induced by HCl/ethanol pylorus ligation (acute ulcer) acetic acid (chronic ulcer).These showed protective healing properties ulcer models. A dose mg/kg two inhibited...

Abstract Objectives In African traditional medicine, Distemonanthus benthamianus (Caesalpiniaceae) is used to treat many diseases including gastric ulcers. We evaluated in this study, the cytoprotective and antisecretory properties of methanolic extract stem bark plant using different technics lesion induction. Methods Cytoprotective activity D. was evolved through six methods induction experimental Wistar male rats (150–200 g): (1) lesions induced by HCl/ethanol, (2) Indomethacin- (3)...

Background: Parastar is an agricultural insecticide formulation composed of two active ingredients; a pyrethroid lambda-cyhalothrin and neonicotinoid imidachloprid used in Cameroon for vegetable protection. Previous studies showed reprotoxicity neurotoxicity this pesticide formulation. Momordica foetida Schumach. Et Thonn medicinal plant with potent antioxidant properties traditionally the treatment several aliments. As farmers are currently exposed to formulation, study was designed...