A5006483097- Advanced NMR Techniques and Applications
- Characterization and Applications of Magnetic Nanoparticles
- NMR spectroscopy and applications
- Nanoparticle-Based Drug Delivery
- Solid-state spectroscopy and crystallography
- Iron oxide chemistry and applications
- Geomagnetism and Paleomagnetism Studies
- Atomic and Subatomic Physics Research
- Lanthanide and Transition Metal Complexes
- Magnetism in coordination complexes
- Magnetic and Electromagnetic Effects
- Electron Spin Resonance Studies
- Inorganic Chemistry and Materials
- Hemoglobinopathies and Related Disorders
- Advanced Physical and Chemical Molecular Interactions
- Nanocluster Synthesis and Applications
- Nuclear reactor physics and engineering
- Public Procurement and Policy
- Laser-Ablation Synthesis of Nanoparticles
- Iron Metabolism and Disorders
- Magnetic and transport properties of perovskites and related materials
- Rare-earth and actinide compounds
- Magnetic Properties and Synthesis of Ferrites
- Optical properties and cooling technologies in crystalline materials
- Urban Planning and Valuation
Max Planck Institute for Multidisciplinary Sciences
2022-2024
National High Magnetic Field Laboratory
2024
Bank of Italy
2023
Institute of Spectroscopy
2021
Max Planck Institute for Biophysical Chemistry
2015-2021
University of Pavia
2013-2020
Istituto Nazionale di Fisica Nucleare, Sezione di Pavia
2020
National Interuniversity Consortium of Materials Science and Technology
2013-2018
National Interuniversity Consortium for the Physical Sciences of Matter
2013-2016
University of Milan
2014
We describe an environmentally friendly, top-down approach to the synthesis of Au89Fe11 nanoparticles (NPs). The plasmonic response gold moiety and magnetism iron coexist in nanoalloy with strong modification compared single element NPs, revealing a non-linear surface plasmon resonance dependence on fraction transition from paramagnetic spin-glass state at low temperature. These nanoalloys are accessible conjugation thiolated molecules they promising contrast agents for magnetic imaging.
Abstract Nuclear magnetic resonance (NMR) is fundamental in the natural sciences, from chemical analysis and structural biology, to medicine physics. Despite its enormous achievements, one of most severe limitations low sensitivity, which arises small population difference nuclear spin states. Methods such as dissolution dynamic polarization parahydrogen induced hyperpolarization can enhance NMR signal by several orders magnitude, however, their intrinsic render multidimensional...
Zinc substitution is often proposed as an efficient strategy to improve the performances of spinel ferrite nanoparticles, particularly related their application theranostic agents. In this work, a series 8 nm nanoparticles formula CoxZnyFe3–(x+y)O4 synthesized by thermal decomposition with purpose investigating role Zn2+ ions in modifying structural and magnetic properties. Contrary most literature on subject, where sum Co Zn kept constant (x + y = 1), here, amount maintained at ca. x 0.6,...
Magnetic resonance imaging (MRI) is at the forefront of non-invasive medical techniques. It provides good spatial and temporal resolution that can be further improved by use contrast agents (CAs), providing a valuable tool for diagnostic purposes. Ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles are attractive MRI due to their negative (T2) enhancement capability biocompatibility. Clusters USPIOs with polymer material particular interest since they sustain additional...
Magnetic nanoparticles (MNPs) are capable of generate heating power under the influence alternating magnetic fields (AMF); this behaviour recently opened new scenarios for advanced biomedical applications, mainly as promising tumor therapies. In paper we have tested called magnetosomes (MNs): a class MNPs naturally produced by magnetotactic bacteria. We extracted MNs from Magnetospirillum gryphiswaldense strain MSR-1 and interaction with cellular elements anti-neoplastic activity both in...
Abstract Nuclear magnetic resonance (NMR) techniques play an essential role in natural science and medicine. In spite of the tremendous utility associated with small energies detected, most severe limitation is low signal‐to‐noise ratio. Dynamic nuclear polarization (DNP), a technique based on transfer from electron to spins, has emerged as tool enhance sensitivity NMR. However, approach liquids still faces several challenges. Herein we report observation room‐temperature, liquid DNP 13 C...
We investigated the theranostic properties of magnetosomes (MNs) extracted from magnetotactic bacteria, promising for nanomedicine applications. Besides a physico‐chemical characterization, their potentiality as mediators magnetic fluid hyperthermia and contrast agents resonance imaging, both in vitro vivo , are here singled out. The MNs, constituted by magnetite nanocrystals arranged chains, show superparamagnetic behaviour clear evidence Verwey transition, signature presence. phospholipid...
Polarization transfer efficiency in liquid-state dynamic nuclear polarization (DNP) depends on the interaction between polarizing agents (PAs) and target nuclei modulated by molecular motions. We show how translational rotational diffusion differently affect DNP efficiency. These contributions were disentangled measuring 1H-DNP enhancements of toluene chloroform doped with nitroxide derivatives at 0.34 T as a function either temperature or size PA. The results employed to analyze 13C-DNP...
Superparamagnetic iron oxide particles find their main application as contrast agents for cellular and molecular magnetic resonance imaging. The they bring is due to the shortening of transverse relaxation time T 2 water protons. In order understand influence on proton relaxation, different theoretical models have been developed, each them presenting a certain validity domain, which depends particle characteristics dynamics. validation these crucial since allow predicting ideal obtaining...
We report a systematic experimental study of the evolution magnetic and relaxometric properties as function metal (Co, Ni) doping in iron oxide nanoparticles. A set five samples, having same size ranging from stoichiometric cobalt ferrite (CoFe2O4) to nickel (NiFe2O4) with intermediate steps, was ad hoc synthesized. Using both DC AC susceptibility measurements, anisotropy depending on is qualitatively discussed. In particular, we observed that height barrier directly proportional amount Co,...
Scalar liquid DNP performance scales of a factor ∼5 depending on the spin density distribution and accessibility radical.
Three-component nanocomposites, constituted by a superparamagnetic iron oxide core coated with polymeric surfactant bearing tightly bound Re(CO)3 moieties, were prepared and fully characterized. The water soluble biocompatible was linear poly(amidoamine) copolymer (PAA), containing cysteamine pendants in the minority part (ISA23SH), able to coordinate fragments. For synthesis of nanocomposites two methods compared, involving either (i) peptization bare magnetite nanoparticles interaction...
Colloidal magnetic nanoparticles (MNPs) based on a nearly monodisperse iron oxide core and capped by oleic acid have been used as model systems for investigating the superparamagnetic spin dynamics means of magnetometry measurements nuclear resonance (1H NMR) relaxometry. The key properties (saturation magnetization, coercive field, frequency dependent "blocking" temperature) MNPs with different size (3.5 nm, 8.5 17.5 nm), shape (spherical cubic), dispersant (hexane water-based formulation)...
Dynamic nuclear polarization (DNP) is a method to enhance the low sensitivity of magnetic resonance (NMR) via spin transfer from electron spins spins. In liquid state, this process mediated by fast modulations electron-nuclear hyperfine coupling and its efficiency depends strongly on applied field. A peculiar case study triphenylphosphine (PPh3) dissolved in benzene doped with BDPA radical because it gives 31P-NMR signal enhancements two orders magnitude up field 14.1 T. Here we show that...
Innovative nanostructures made of a high payload fluorophores and superparamagnetic nanoparticles (NPs) have simply been fabricated upon self-assembling in two-step process. The resulting hybrid supraparticles displayed dense shell iron oxide tightly attached through an appropriate polyelectrolyte to highly emissive non-doped nanocore more than 105 small organic molecules. Cooperative magnetic dipole interactions arose due the closely packed NPs at nanoarchitecture surface, causing enhanced...
Dynamic nuclear polarization in the liquid state via Overhauser effect is enabled by fluctuations of electron-nuclear hyperfine interaction. Fermi contact (or scalar) coupling can be modulated molecular collisions on timescales a few picoseconds and shorter, enabling an effective transfer even at high magnetic fields. However, only studies have presented theoretical analysis scalar mechanism. Here we report current understanding relaxation liquid-state DNP present different modeling...
Spin in semiconductors facilitates magnetically controlled optoelectronic and spintronic devices. In metal halide perovskites (MHPs), doping magnetic ions is proven to be a simple efficient approach introducing spin momentum. this work, we present facile ion protocol through the vapor-phase insertion reaction chemical vapor deposition (CVD)-grown ultrathin Cs3BiBr6 perovskites. The Fe-doped bismuth (Fe:CBBr) demonstrate that iron spins are successfully incorporated into lattice, as revealed...
We report a broadband 1H NMR study of the spin dynamics coated maghemite and gold–maghemite hybrid nanostructures with two different geometries, namely dimers core–shells. All samples have superparamagnetic behavior, displaying blocking temperature (TB ∼ 80 K (maghemite), ∼105 (dimer), ∼150 (core–shell)), magnetization reversal time follows Vogel–Fulcher law. observed three anomalies in T1–1 versus T that decrease amplitude when increasing applied magnetic field. suggest are related to...
In this work we present a detailed NMR and ${\ensuremath{\mu}}^{+}\mathrm{SR}$ investigation of the spin dynamics in new hydrated sodium salt containing single-ion magnet ${[\mathrm{Er}{({\mathrm{W}}_{5}{\mathrm{O}}_{18})}_{2}]}^{9\ensuremath{-}}$. The $^{1}\mathrm{H}\phantom{\rule{0.16em}{0ex}}\mathrm{NMR}$ absorption spectra at various applied magnetic fields line broadening on decreasing temperature which indicates progressive freezing single-molecule moments. onset quasistatic local...
Advanced nanostructured materials, such as gold nanoparticles, magnetic and multifunctional are nowadays used in many state-of-the-art biomedical application. However, although the engineering this field is very advanced, there remain some fundamental problems involving interaction mechanisms between nanostructures cells or tissues. Here we show potential of (1)H NMR investigation uptake two different kinds nanostructures, that is, maghemite a chemotherapy drug (Temozolomide) glioblastoma...
By means of muon spin relaxation measurements we unraveled the temperature dynamics in monodisperse maghemite spherical nanoparticles with different surface to volume ratio, two samples a full core (diameter $D\ensuremath{\sim}4$ and $D\ensuremath{\sim}5\phantom{\rule{4pt}{0ex}}\mathrm{nm}$) one hollow (external diameter $D\ensuremath{\sim}7.4\phantom{\rule{0.16em}{0ex}}\mathrm{nm}$). The behavior longitudinal rates as function allowed us identify distinct dynamics. first is well witnessed...
Abstract Nuclear magnetic resonance (NMR) techniques play an essential role in natural science and medicine. In spite of the tremendous utility associated with small energies detected, most severe limitation is low signal‐to‐noise ratio. Dynamic nuclear polarization (DNP), a technique based on transfer from electron to spins, has emerged as tool enhance sensitivity NMR. However, approach liquids still faces several challenges. Herein we report observation room‐temperature, liquid DNP 13 C...