A5004080391- Nanoparticle-Based Drug Delivery
- Characterization and Applications of Magnetic Nanoparticles
- Iron oxide chemistry and applications
- Nanoparticles: synthesis and applications
- Microfluidic and Bio-sensing Technologies
- Comparative and International Law Studies
- Luminescence and Fluorescent Materials
- Lanthanide and Transition Metal Complexes
- Nanoplatforms for cancer theranostics
- Migration, Identity, and Health
- Supramolecular Self-Assembly in Materials
- NMR spectroscopy and applications
- Ionic liquids properties and applications
- Advanced NMR Techniques and Applications
- Law, logistics, and international trade
- European and International Contract Law
- Magnetic Properties and Synthesis of Ferrites
- Advanced MRI Techniques and Applications
- Supramolecular Chemistry and Complexes
- Diamond and Carbon-based Materials Research
- Biosensors and Analytical Detection
- Advanced biosensing and bioanalysis techniques
- Catalytic Processes in Materials Science
- Muon and positron interactions and applications
- Blood properties and coagulation
Centre National de la Recherche Scientifique
2011-2020
Nantes Université
2016-2020
Chimie et Interdisciplinarité, Synthèse, Analyse, Modélisation
2016-2020
Institut Charles Gerhardt Montpellier
2009-2019
Université de Montpellier
2009-2019
École Nationale Supérieure de Chimie de Montpellier
2009-2019
Université Paris Cité
2012-2018
Laboratoire Matériaux et Phénomènes Quantiques
2014-2018
Laboratoire Matière et Systèmes Complexes
2012-2016
Sorbonne Paris Cité
2012-2016
Iron oxide nanocrystals (IONCs) are appealing heat mediator nanoprobes in magnetic-mediated hyperthermia for cancer treatment. Here, specific absorption rate (SAR) values reported cube-shaped water-soluble IONCs prepared by a one-pot synthesis approach size range between 13 and 40 nm. The SAR were determined as function of frequency magnetic field applied, also spanning technical conditions which considered biomedically safe patients. Among the different sizes tested, with an average...
In the pursuit of optimized magnetic nanostructures for diagnostic and therapeutic applications, role nanoparticle architecture has been poorly investigated. this study, we demonstrate that internal collective organization multi-core iron oxide nanoparticles can modulate their properties in such a way as to critically enhance hyperthermic efficiency MRI T(1) T(2) contrast effect. Multi-core composed maghemite cores were synthesized through polyol approach, subsequent electrostatic colloidal...
Magnetic nanoparticles exhibit a high potential to selectively treat cancer by hyperthermia provided that heating capacity can be reached. In this work, we report an efficient synthesis of novel structures magnetic iron oxide. The particles, obtained applying modified "polyol" protocol, present particular shape: they look constituted smaller grains approximately 11 nm, assembled in flower-shaped structure. These nanoflowers, dispersed water at physiological pH, particularly interesting...
Synthesis of functionalized magnetic nanoparticles (NPs) for biomedical applications represents a current challenge. In this paper we present the synthesis and characterization water-dispersible sugar-coated iron oxide NPs specifically designed as fluid hyperthermia heat mediators negative contrast agents resonance imaging. particular, influence inorganic core size was investigated. To end, with average in range 4-35 nm were prepared by thermal decomposition molecular precursors then coated...
The long-term fate of nanomaterials in biological environment represents a critical matter, which determines environmental effects and potential risks for human health. Predicting these requires understanding nanoparticle transformations, persistence, degradation, some issues somehow ignored so far. Safe by design, inorganic nanostructures are being envisioned therapy, yet fundamental principles their processing systems, change physical properties, situ degradability have not been thoroughly...
Several studies propose nanoparticles for tumor treatment, yet little is known about the fate of and intimate interactions with heterogeneous ever-evolving environment. The latter, rich in extracellular matrix, responsible poor penetration therapeutics represents a paramount issue cancer therapy. Hence new strategies start aiming to modulate neoplastic stroma. From this perspective, we assessed efficacy 19 nm PEG-coated iron oxide nanocubes optimized magnetic properties mediate mild...
Safe implementation of nanotechnology and nanomedicine requires an in-depth understanding the life cycle nanoparticles in body. Here, we investigate long-term fate gold/iron oxide heterostructures after intravenous injection mice. We show these degrade vivo that magnetic optical properties change during degradation process. These particles eventually eliminate from The comparison two different coating shells for heterostructures, amphiphilic polymer or polyethylene glycol, reveals long...
One of the first biointeractions magnetic nanoparticles with living systems is characterized by nanoparticle-protein complex formation. The proteins dynamically encompass particles in protein corona. Here we propose a method based on nanomagnetism that allows specific situ monitoring interactions between iron oxide and blood plasma. Tracking nanoparticle orientation through their optical birefringence signal induced an external field provides quantitative real-time detection corona at...
The current challenge in the field of nanomedicine is design multifunctional nano-objects effective both for diagnosis and treatment diseases. Here, dendronized FeO1–x@Fe3–xO4 nanoparticles with spherical, cubic, octopode shapes oxidized Fe3–xO4 nanocubes have been synthesized structurally magnetically characterized. Strong exchange bias properties are highlighted core–shell (NPs) due to magnetic interactions between their antiferromagnetic core ferrimagnetic shell. Both vitro relaxivity...
Abstract The labeling of stem cells with iron oxide nanoparticles is increasingly used to enable MRI cell tracking and magnetic manipulation, stimulating the fields tissue engineering therapy. However, impact on stem‐cell differentiation still controversial. One compromising factor for successful may arise from early interactions during procedure. It hypothesized that lack control over nanoparticle colloidal stability in biological media lead undesirable localization, overestimation cellular...
Given the promise of carbon nanotubes (CNTs) for photothermal therapy, drug delivery, tissue engineering, and gene there is a need non‐invasive imaging methods to monitor CNT distribution fate in body. In this study, non‐ionizing whole‐body high field magnetic resonance (MRI) used follow water‐dispersible non‐toxic functionalized CNTs administrated intravenously mice. Oxidized are endowed with positive MRI contrast properties by covalent functionalization chelating ligand...
Understanding the relation between structure and reactivity of nanomaterials in organism is a crucial step towards efficient safe biomedical applications. The multi‐scale approach reported here, allows following magnetic structural transformations multicore maghemite nanoflowers medium mimicking intracellular lysosomal environment. By confronting atomic‐scale macroscopic information on biodegradation these complex nanostuctures, we can unravel mechanisms involved critical alterations their...
Water-soluble biocompatible rhamnose-coated Fe3O4 nanoparticles of 4.0 nm are obtained by covalent anchorage rhamnose on the surface via a phosphate linker. These present superparamagnetic behavior and nuclear relaxivities in same order magnitude as Endorem that make them potential magnetic resonance imaging (MRI) contrast agents second generation, where saccharides represent also specific ligands able to target lectins skin cells.
Abstract Bright supramolecular fluorescent organic nanoassemblies (FONs), based on strongly polar red‐emissive benzothiadiazole fluorophores containing acidic units, are fabricated to serve as theranostic tools with large colloidal stability in the absence of a polymer or surfactant. High architectural cohesion is ensured by multiple hydrogen‐bonding networks, reinforced dipolar and hydrophobic interactions developed between dyes. Such harnessed ensure high payload encapsulation efficient...
We present a systematic experimental comparison of the superparamagnetic relaxation time constants obtained by means dynamic magnetic measurements and (1)H-NMR relaxometry, on ferrite-based nanosystems with different composition, various core sizes dispersed in solvents. The application heuristic model for relaxivity allowed between reversal magnetization as seen NMR results from AC susceptibility experiments, an estimation fundamental microscopic properties. A good agreement was found when...
In this study the thermosensitivity of malignant glioblastoma cells (U87-MG), incubated with superparamagnetic 10 nm sized polyol-made γ-Fe<sub>2</sub>O<sub>3</sub>particles and exposed to an alternating magnetic field (700 kHz, 23.10 kA m<sup>−1</sup>) for 1 hour, is evidenced.