A5000648931- Antibiotic Use and Resistance
- Urinary Tract Infections Management
- Bacterial Identification and Susceptibility Testing
- Patient Satisfaction in Healthcare
- Pneumonia and Respiratory Infections
- Streptococcal Infections and Treatments
- Respiratory and Cough-Related Research
- Urinary Bladder and Prostate Research
- Pelvic floor disorders treatments
- Gut microbiota and health
- Pediatric Urology and Nephrology Studies
- Healthcare Systems and Technology
- Antibiotic Resistance in Bacteria
- Human-Animal Interaction Studies
- Mental Health Treatment and Access
- Global Maternal and Child Health
- COVID-19 and Mental Health
- Patient-Provider Communication in Healthcare
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Emergency and Acute Care Studies
- Zoonotic diseases and public health
- Resilience and Mental Health
- Clinical Reasoning and Diagnostic Skills
- Otolaryngology and Infectious Diseases
- Public Health and Social Inequalities
University of Copenhagen
2014-2023
University of KwaZulu-Natal
2023
Universidad Mariana
2018
Danish National Institute of Public Health
2014
University of Southern Denmark
2011-2013
Rigshospitalet
2010
Cochrane
2010
Background Although uncomplicated urinary tract infections (UTIs) are often self-limiting, most patients will be prescribed antibiotic treatment. We assessed whether treatment with ibuprofen was non-inferior to pivmecillinam in achieving symptomatic resolution by day 4, a non-inferiority margin of 10%. Methods and findings This randomized, controlled, double-blind trial. recruited from 16 sites general practice setting Norway, Sweden, Denmark. Non-pregnant women aged 18–60 years presenting...
Excessive use of antibiotics is worldwide the most important reason for development antimicrobial resistance. As antibiotic resistance may spread across borders, high prevalence countries serve as a source bacterial with low prevalence. Therefore, an issue potential serious impact on all countries. Initiatives have been taken to improve quality prescribing in primary care, but only few studies designed determine effectiveness multifaceted strategies different practice setting. The aim this...
Objective: The aim of this study was to describe and characterize the prescription antibiotics for urinary tract infection (UTI) in general practice Denmark evaluate compliance with current recommendations.Design: National registry-based studySetting: Danish practicePatients: 267.539 patients who redeemed a clinical indication UTI at community pharmacies between July 1st 2012 June 31st 2013.Main outcome measures: Antibiotics prescribed 1) acute lower UTI, 2) upper 3) recurrent presented as...
Escherichia coli is the most common pathogen causing Urinary Tract Infections (UTI). Data from current National Surveillance program in Denmark (DANMAP) may not accurately represent prevalence of resistant E. primary care, because only urine samples complicated cases be forwarded to microbiological departments at hospitals for diagnostic examination. The aim this study was assess commonly used antimicrobial agents care a consecutive sample patients general practice. Observational carried out...
Variation in prescription of antibiotics primary care can indicate poor clinical practice that contributes to the increase resistant strains. General Practitioners (GPs), as a professional group, are expected have fairly homogeneous prescribing style. In this paper, we describe variation style within and across groups GPs from six countries.Cross-sectional study with inclusion 457 6394 sore throat patients. We for patients countries assess whether "prescribing style"--understood subjective...
Antimicrobial resistance (AMR) is an increasing threat to global health. The risks and sanitary consequences of AMR are disproportionately experienced by those living in Low- Middle-Income Countries (LMICs). While addressing antibiotic use has largely been documented hospital settings, the understanding social drivers affecting prescribing dispensing practices context human animal health primary care (PC) LMICs remains extremely limited. We seek explore how in-locus multi-level factors...
Background: The aim of this study was to describe the antibiotic prescribing rate in patients with acute exacerbation chronic obstructive pulmonary disease (AECOPD), analyse predictors for and explore influence use C-reactive protein (CRP) rapid test. Methods: A cross-sectional carried out January February 2008 primary care. General practitioners (GPs) from six countries (Denmark, Sweden, Lithuania, Russia, Spain Argentina) registered all AECOPD during a 3-week period. multilevel logistic...
Objective. To assess the potential overprescribing in patients with acute rhinosinusitis across six countries different antibiotic prescribing rates and prevalence of resistance. Design, setting subjects. A cross-sectional study including GPs from two Nordic countries, Baltic Hispano-American registered respiratory tract infections (RTIs) during three weeks January 2008 as part EU-funded project "Health Alliance for Prudent Prescribing, Yield And Use antimicrobial Drugs In Treatment...
Background Clinical signs of urinary tract disease in dogs often lead to prescription antibiotics. Appropriate diagnostic work‐up could optimize treatment and reduce the risk inappropriate use Hypothesis/Objectives To describe evaluate impact on decision treat (DTT) choice antibiotic (COT) for presenting with clinical disease. Animals One hundred fifty‐one 52 Danish veterinary practices. Methods Prospective, observational study. signs, work‐up, prescriptions were recorded. Urine samples...
This article explores stakeholders' perceptions of the challenges for developing a One Health agenda to tackle antimicrobial resistance (AMR) in Brazil, including development and implementation Brazilian National Action Plan (BR-NAP). The data originate from 27 interviews conducted with human, environmental, animal health stakeholders, academics, managers, policymakers involved BR-NAP. Through thematic analysis, we identified three interconnected themes: governance, system, technical...
To evaluate the effectiveness of two types intervention in reducing antibiotic prescribing respiratory tract infections (RTI).Before-after audit-based study.Primary Care centres Spain.General practitioners (GPs) registered all patients with RTIs for 15 days winter 2008 (pre-intervention), and again 2009 (post-intervention).Intervention activities included meetings, presentation discussion results, several training meetings on RTI guidelines, information brochures patients, workshops...
Excessive and inappropriate use of antibiotics is the most important driver antimicrobial resistance. The aim HAPPY PATIENT project to evaluate adaptation European Union (EU) recommendations on prudent antimicrobials in human health by evaluating impact a multifaceted intervention targeting different categories healthcare professionals (HCPs) common community-acquired infectious diseases, especially respiratory urinary tract infections.
Urinary tract infection (UTI) is a common in primary care and the second leading reason for prescription of antibiotics Denmark. The diagnosis often based on symptoms urine dip-stick, which has limited validity, causing risk unnecessary antibiotic prescription. Additionally, with increasing resistance, choosing an to infecting pathogen resistant rising. Combined point-of-care-tests (POCT) culture susceptibility testing have been developed validated care, performing such test all patients...
Misconceptions and knowledge gaps about antibiotics contribute to inappropriate antibiotic use antimicrobial resistance. This study aimed identify prioritize misconceptions from a healthcare professionals' perspective. A modified Delphi with predefined list of statements, two questionnaire rounds, an expert meeting was conducted. The statements were rated by professionals France, Greece, Lithuania, Poland, Spain, general practice, out-of-hour services, nursing homes, pharmacies. total 44...
Objectives To investigate the effect of adding point-of-care (POC) susceptibility testing to POC culture on appropriate use antibiotics as well clinical and microbiological cure for patients with suspected uncomplicated urinary tract infection (UTI) in general practice. Design Open, individually randomised controlled trial. Setting General Participants Women UTI, including elderly above 65, recurrent UTI diabetes. The sample size calculation predicted 600 were needed. Interventions Flexicult...
ObjectivesTo describe and compare antibiotic prescribing patterns for primary care patients with respiratory tract infections (RTIs) in four South American countries.
Inappropriate prescription of antibiotics is the leading driver antimicrobial resistance (AMR). The majority are prescribed in primary care. Understanding how general practitioners (GPs) use diagnostic tests and effect on treatment decision under daily practice conditions important to reduce inappropriate antibiotics. aim study was investigate care patients with suspected urinary tract infection (UTI) assess appropriateness (TD) Denmark. Prospective observational study. Symptomatic adult...