A5011106408- Bipolar Disorder and Treatment
- Child and Adolescent Psychosocial and Emotional Development
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neural and Behavioral Psychology Studies
- Adolescent and Pediatric Healthcare
- Functional Brain Connectivity Studies
- Genetics and Neurodevelopmental Disorders
- Attention Deficit Hyperactivity Disorder
- Mental Health Research Topics
- Neurological disorders and treatments
- Psychosomatic Disorders and Their Treatments
- Schizophrenia research and treatment
- Neurobiology of Language and Bilingualism
- Stuttering Research and Treatment
- Electrolyte and hormonal disorders
- Advanced Neuroimaging Techniques and Applications
- Obsessive-Compulsive Spectrum Disorders
- Reading and Literacy Development
- Maternal Mental Health During Pregnancy and Postpartum
- Memory and Neural Mechanisms
- Motor Control and Adaptation
- Hemodynamic Monitoring and Therapy
- Advanced MRI Techniques and Applications
- Electroconvulsive Therapy Studies
- Cardiovascular and Diving-Related Complications
University of America
2014-2021
Catholic University of America
2014-2021
National Institute of Mental Health
2013-2016
National Institutes of Health
2011-2016
San Diego State University
2016
University of Denver
2016
Stanford University
2001-2013
Inhibitory control and performance monitoring are critical executive functions of the human brain. Lesion imaging studies have shown that inferior frontal cortex plays an important role in inhibition inappropriate response. In contrast, specific brain areas involved error processing their relation to those implicated inhibitory processes unknown. this study, we used a random effects model investigate error-related activity associated with failure inhibit response during Go/NoGo task....
Background:The neurobiological features of pediatric bipolar disorder (BD) are largely unknown.Children and adolescents with BD may be important to study functional neuroimaging techniques because their unique status early-onset high familial loading for the disorder.Neuroimaging studies adults have implicated dorsolateral prefrontal cortex (DLPFC) anterior cingulate (ACC) in development this disorder.Objectives: To children via magnetic resonance imaging using cognitive affective tasks...
Objective: Bipolar disorder and disruptive mood dysregulation (DMDD) are clinically pathophysiologically distinct, yet irritability can be a clinical feature of both illnesses. The authors examine whether the neural mechanisms mediating differ between bipolar DMDD, using face emotion labeling paradigm because such is deficient in patient groups. hypothesized that during labeling, would associated with dysfunctional activation amygdala other temporal prefrontal regions disorders, but nature...
Background: There is debate as to whether chronic irritability (operationalized severe mood dysregulation, SMD) a developmental form of bipolar disorder (BD). Although structural brain abnormalities in BD have been demonstrated, no study compares neuroanatomy among SMD, BD, and healthy volunteers (HV) either cross‐sectionally or over time. Furthermore, the trajectories SMD are unknown. This provides such data HV. Methods: An optimized, modulated voxel‐based morphometry (VBM) analysis was...
Article AbstractBackground: Offspring of parents with bipolar disorder, by virtue their high-risk status for developing merit an investigation the efficacy treatment mood stabilizers. Behavioral and difficulties in this population may represent prodromal forms disorder. We studied divalproex treating child adolescent offspring or behavioral disorders who did not yet meet criteria I II Method: 24 children aged 6-18 years (mean = 11.3 years; 17 boys/7 girls) at least 1 biological parent...
Background Research in bipolar disorder (BD) implicates fronto-limbic-striatal dysfunction during face emotion processing but it is unknown how such varies by task demands, and patient age. Method During functional magnetic resonance imaging (fMRI), 181 participants, including 62 BD (36 children 26 adults) 119 healthy comparison (HC) subjects (57 adults), engaged constrained unconstrained of emotional (angry, fearful, happy) non-emotional (neutral) faces. processing, answered questions...
Objectives: Pediatric bipolar disorder is characterized by core deficits in mood and executive function commonly co-occurs with attention-deficit/hyperactivity (ADHD). We aimed to examine response inhibition this population, as an element of function, which, if aberrant, may interfere learning information processing. Methods: Children (9–18 years) I or II (BD, n = 26) age, gender, intelligence quotient (IQ) comparable healthy children (HC, 22) without any psychopathology were given a...
The nature of the hemodynamic response (HDR) is still not fully understood due to multifaceted processes involved. Aside from overall amplitude, may vary across cognitive states, tasks, brain regions, and subjects with respect characteristics such as rise fall speed, peak duration, undershoot shape, duration. Here we demonstrate that fixed-shape (FSM) or adjusted-shape (ASM) methods fail detect some shape subtleties (e.g., speed recovery, undershoot). In contrast, estimated-shape method...
Abstract Objectives Bipolar disorder (BD) and familial risk for BD have been associated with aberrant white matter (WM) microstructure in the corpus callosum fronto‐limbic pathways. These abnormalities might constitute trait or state marker suggested to result from maturation relate difficulties emotion regulation. Methods To determine whether WM alterations represent a trait, disease resilience marker, we compared youth at (n = 36 first‐degree relatives, REL) 36) healthy volunteers 36, HV)...
Objective: Divalproex has been found efficacious in treating adolescents with and at high risk for bipolar disorder (BD), but little is known about the effects of mood stabilizers on brain itself. We sought to examine divalproex structure, chemistry, function specific regions children high-risk BD. Methods: A total 24 dysregulation not full BD, all offspring a parent were treated monotherapy 12 weeks. subset 11 subjects 6 healthy controls scanned magnetic resonance imaging (MRI, spectroscopy...
Adolescence is a time of increased risk for the onset psychological disorders associated with deficits in face emotion labeling. We used functional magnetic resonance imaging (fMRI) to examine age-related differences brain activation while adolescents and adults labeled on fearful, happy angry faces varying intensities [0% (i.e. neutral), 50%, 75%, 100%]. Adolescents did not differ accuracy label emotions. In superior temporal sulcus, ventrolateral prefrontal cortex middle gyrus, show an...