A5058133902- Bipolar Disorder and Treatment
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health Research Topics
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Attention Deficit Hyperactivity Disorder
- Fetal and Pediatric Neurological Disorders
- Schizophrenia research and treatment
- Electroconvulsive Therapy Studies
- Stuttering Research and Treatment
- Advanced MRI Techniques and Applications
- Neural and Behavioral Psychology Studies
- Archaeology and Historical Studies
- Neurological disorders and treatments
- Genetics and Neurodevelopmental Disorders
- Ancient Egypt and Archaeology
- Electrolyte and hormonal disorders
- Clinical Nutrition and Gastroenterology
- Resilience and Mental Health
- Archaeological Research and Protection
- Obsessive-Compulsive Spectrum Disorders
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Cellular transport and secretion
University of Freiburg
2023-2024
The University of Texas Health Science Center at Houston
2023-2024
Erasmus University Rotterdam
2024
National Institute of Mental Health
2019-2023
National Institutes of Health
2019-2023
Johannes Gutenberg University Mainz
2013-2021
Centre d'Acquisition et de Traitement des Images
2016
Assistance Publique – Hôpitaux de Paris
2015-2016
Institut Mondor de Recherche Biomédicale
2016
CEA Paris-Saclay
2016
<h3>Importance</h3> Tractography studies investigating white matter (WM) abnormalities in patients with bipolar disorder have yielded heterogeneous results owing to small sample sizes. The size limits their generalizability, a critical issue for neuroimaging of biomarkers I (BPI). <h3>Objectives</h3> To study WM using whole-brain tractography large international multicenter BPI and compare these alterations between or without history psychotic features during mood episodes. <h3>Design,...
Bipolar I disorder is highly heritable, but endophenotypes of the mediating genetic risk are only beginning to be defined. The authors investigate state- and trait-related neural mechanisms related motivation in euthymic bipolar patients unaffected first-degree relatives define status motivational processing as a systems-level endophenotype. Our study comprised two samples; first consisted 19 matched comparison subjects, second included 22 subjects. Motivational was assessed with...
Objective: Anxiety disorders are prevalent among youths and often highly impairing. Cognitive-behavioral therapy (CBT) is an effective first-line treatment. The authors investigated the brain mechanisms associated with symptom change following CBT. Methods: Unmedicated diagnosed anxiety disorder underwent 12 weeks of CBT as part two randomized clinical trials testing efficacy adjunctive computerized cognitive training. Across both trials, participants completed a threat-processing task...
Bipolar disorder is characterized by a functional imbalance between hyperactive ventral/limbic areas and hypoactive dorsal/cognitive brain regions potentially contributing to affective cognitive symptoms. Resting-state studies in bipolar have identified abnormal connectivity these regions. However, most of used seed-based approach, thus restricting the number that were analyzed. Using data-driven approaches, researchers resting state networks whose spatial maps overlap with frontolimbic such...
Objective There is growing evidence that cerebellum plays a crucial role in cognition and emotional regulation. Cerebellum likely to be involved the physiopathology of both bipolar disorder schizophrenia. The objective our study was compare cerebellar size between patients with disorder, schizophrenia, healthy controls multicenter sample. In addition, we studied influence psychotic features on disorder. Method One hundred fifteen I 32 52 underwent 3 Tesla MRI . Automated segmentation...
IMPORTANCEThe clinical heterogeneity of schizophrenia has hindered neurobiological investigations aimed at identifying neural correlates the disorder.OBJECTIVE To identify network-based biomarkers across spectrum impairment present in by separately evaluating individuals with deficit and nondeficit subtypes this disorder. DESIGN, SETTING, AND PARTICIPANTSA university hospital neuroimaging study was conducted between February 1, 2007, 28, 2012.Participants included patients (n = 128) matched...
Previous studies have reported MRI abnormalities of the corpus callosum (CC) in patients with bipolar disorder (BD), although only a few directly compared callosal areas psychotic versus nonpsychotic this disorder. We sought to compare regional large international multicentre sample BD and healthy controls.We analyzed anatomic T1 data BD-I controls recruited from 4 sites (France, Germany, Ireland United States). obtained mid-sagittal 7 CC subregions using an automatic delineation....
The Affective Reactivity Index (ARI) is widely used to assess young people's irritability symptoms, but youth and caregivers often diverge in their assessments. Such informant discrepancy might be rooted poor psychometric properties, the differential conceptualization of across informants, or reflect sociodemographic clinical characteristics. We use an out-of-sample replication approach leverage longitudinal data, available for a subset participants, test these hypotheses. Across two...
Abstract Objectives Bipolar disorder (BD) and familial risk for BD have been associated with aberrant white matter (WM) microstructure in the corpus callosum fronto‐limbic pathways. These abnormalities might constitute trait or state marker suggested to result from maturation relate difficulties emotion regulation. Methods To determine whether WM alterations represent a trait, disease resilience marker, we compared youth at (n = 36 first‐degree relatives, REL) 36) healthy volunteers 36, HV)...
BackgroundImaging research has not yet delivered reliable psychiatric biomarkers. One challenge, particularly among youth, is high comorbidity. This challenge might be met through canonical correlation analysis designed to model mutual dependencies between symptom dimensions and neural measures. We mapped the multivariate associations that intrinsic functional connectivity manifests with pediatric symptoms of anxiety, irritability, attention-deficit/hyperactivity disorder (ADHD) as common,...
Abstract Irritability, defined as proneness to anger, is among the most common reasons youth are seen for psychiatric care. Youth with irritability demonstrate aberrant processing of anger-related stimuli; however, neural mechanisms remain unknown. We applied a drift-diffusion model (DDM), computational tool, derive latent behavioral metric attentional bias angry faces in varying levels during functional magnetic resonance imaging (fMRI). examined associations irritability, task behavior...
Inhibitory control is central to many theories of cognitive and brain development, impairments in inhibitory are posited underlie developmental psychopathology. In this study, we tested the possibility shared versus unique associations between three common symptom dimensions youth psychopathology: attention-deficit/hyperactivity disorder (ADHD), anxiety, irritability. We quantified using four different experimental tasks estimate a latent variable 246 (8–18 years old) with varying types...
ObjectiveIrritability, inattention, and hyperactivity, which are common presentations of childhood psychopathology, have been associated with perturbed white matter microstructure. However, similar tracts implicated across these phenotypes; such non-specificity could be rooted in their high co-occurrence. To address this problem, we use a bifactor approach parsing unique shared components irritability, then relate to microstructure.MethodWe developed model based on the Conners Comprehensive...
Brain sulcation is an indirect marker of neurodevelopmental processes. Studies the cortical in bipolar disorder have yielded mixed results, probably due to high variability clinical phenotype. We investigated whole-brain a large sample selected patients with load.A total 263 I and 320 controls were included multicentric magnetic resonance imaging (MRI) study. All subjects underwent high-resolution T1-weighted brain MRI. Images processed automatized pipeline extract global sulcal index (g-SI)...