A5102856253- Nanoplatforms for cancer theranostics
- Image Enhancement Techniques
- Advanced Vision and Imaging
- Advanced Image Processing Techniques
- Video Coding and Compression Technologies
- Immunotherapy and Immune Responses
- Advanced Glycation End Products research
- Advanced Image and Video Retrieval Techniques
- Photodynamic Therapy Research Studies
- Advanced Image Fusion Techniques
- Immune cells in cancer
- Protein Degradation and Inhibitors
- Supramolecular Self-Assembly in Materials
- Advanced Data Compression Techniques
- Advanced Nanomaterials in Catalysis
- Nanoparticle-Based Drug Delivery
- Sulfur Compounds in Biology
- Ubiquitin and proteasome pathways
- Peptidase Inhibition and Analysis
- Advanced biosensing and bioanalysis techniques
- Biochemical effects in animals
- Cancer Immunotherapy and Biomarkers
- Alzheimer's disease research and treatments
- Image Retrieval and Classification Techniques
- Advanced Fluorescence Microscopy Techniques
Shanghai Institute of Materia Medica
2021-2025
Chinese Academy of Sciences
2021-2025
Xi’an University of Posts and Telecommunications
2016-2023
Renji Hospital
2023
Shanghai Jiao Tong University
2023
East China Normal University
2019-2022
Fudan University
2022
Huadong Hospital
2022
University of Electronic Science and Technology of China
2021
Ministry of Public Security of the People's Republic of China
2017-2019
The critical challenge for cancer vaccine-induced T-cell immunity is the sustained activation of antigen cross-presentation in antigen-presenting cells (APCs) with innate immune stimulation. In this study, it first discovered that clinically used magnetic contrast agents, iron oxide nanoparticles (IONPs), markedly augment type-I interferon (IFN-I) production profile stimulator genes (STING) agonist MSA-2 and achieve a 16-fold dosage-sparing effect human STING haplotype. Acid-ionizable...
Abstract Radiation therapy (RT) is one of the primary options for clinical cancer therapy, in particular advanced head and neck squamous cell carcinoma (HNSCC). Herein, crucial role bromodomain‐containing protein 4 (BRD4)‐RAD51 associated 1 (RAD51AP1) axis sensitizing RT HNSCC revealed. A versatile nanosensitizer (RPB7H) thus innovatively engineered by integrating a PROteolysis TArgeting Chimeras (PROTAC) prodrug (BPA771) hafnium dioxide (HfO 2 ) nanoparticles to downregulate BRD4‐RAD51AP1...
Immunotherapy aiming to harness the exquisite power of immune system has emerged as a crucial part clinical cancer management. However, only subset patients responds current immunotherapy because low immunogenicity tumor cells and immunosuppressive microenvironment. Herein, host-guest prodrug nanovectors are reported for active targeting combating tolerance in tumors. The designed by integrating hyaluronic acid (HA) reduction-labile heterodimer Pheophorbide A (PPa) NLG919 into supramolecular...
Abstract Second near‐infrared (NIR‐II) fluorescence imaging with deep tissue‐penetration ability holds remarkable potential for cancer diagnosis. However, clinical translation of NIR‐II imaging‐based treatment is severely restricted by the low signal‐to‐background ratio due to insufficient tumor specificity fluorophores. In this study, it hypothesized that methylglyoxal (MGO), an intermediate metabolite glycolysis could be used as a potent biomarker triggering imaging‐guided theranostic. For...
The immune-excluded tumors (IETs) show limited response to current immunotherapy due intrinsic and adaptive immune resistance. In this study, it is identified that inhibition of transforming growth factor-β (TGF-β) receptor 1 can relieve tumor fibrosis, thus facilitating the recruitment tumor-infiltrating T lymphocytes. Subsequently, a nanovesicle constructed for tumor-specific co-delivery TGF-β inhibitor (LY2157299, LY) photosensitizer pyropheophorbide (PPa). LY-loaded nanovesicles suppress...
Abstract Nanomedicines that inhibit/disassemble amyloid β (Aβ) aggregates in Alzheimer's disease (AD) are highly desirable yet remain challenging. Therapeutic efficacy and systemic delivery of reported molecules nanoparticles (NPs) hampered by various challenges, including low biocompatibility, off‐target toxicity, lack specificity. Herein, a versatile NP is designed integrating high Aβ‐binding affinity, stimuli‐responsive drug release, photothermal degradation properties for efficient...
Abstract Glioblastoma (GBM) is the most aggressive subtype of primary brain tumors, which marginally respond to standard chemotherapy due blood‐brain barrier (BBB) and low tumor specificity therapeutics. Herein, a double‐layered microneedle (MN) patch rationally engineered by integrating acid light dual‐activatable PROteolysis TArgeting Chimera (PROTAC) nanoparticles self‐oxygenating BSA‐MnO 2 (BM) for GBM treatment. The MN administrated at site locally deliver PROTAC prodrug BM...
Clear elucidation of the changes in Alzheimer's disease (AD)-related methylglyoxal (MGO) levels vivo is significant yet highly challenging. Fluorescence imaging second near-infrared region (NIR-II, 1000-1700 nm) has gained increasing attention as an observation method living organisms, but MGO-activatable fluorescent probe that emits this for brain lacking because existence blood-brain barrier (BBB). Herein, a biocompatible Fe3O4 nanoparticle (IONP)-conjugated NIR-II (MAM) modified with...
Glioblastoma (GBM) therapy is severely impaired by the blood-brain barrier (BBB) and invasive tumor growth in central nervous system. To improve GBM therapy, we herein presented a dual-targeting nanotheranostic for second near-infrared (NIR-II) fluorescence imaging-guided photo-immunotherapy. Firstly, NIR-Ⅱ fluorophore MRP bearing donor-acceptor-donor (D-A-D) backbone was synthesized. Then, prodrug nanotheranostics were prepared self-assembling with of JQ1 (JPC) T7 ligand-modified...
This work aims to study the role of Digital Twins (DTs) technology combined with Metaheuristic Optimization Algorithm in manufacturing energy efficiency optimization. Firstly,a machine tool model is established based on DTs consumption milling process Computer Numerical Machine Tools. Besides, Particle Swarm (PSO) algorithm introduced optimize parameters machining process. Meanwhile, path optimized by combining Optimized Genetic and Simulated Annealing find optimal solution path. On premise...
Abstract The advance of immunotherapy has shifted the paradigm cancer management in clinics. Nevertheless, a considerable subset pancreatic ductal adenocarcinoma (PDAC) patients marginally respond to current due occurrence dynamic immune evasion arising from intrinsic and therapeutic stress. In this investigation, pivotal role cancer‐associated fibroblast (CAF)‐induced fibrosis tumor cell‐mediated T‐cell exhaustion driving is identified. Building upon discovery, authors herein engineer novel...
Abstract Tumor metastasis is considered a major cause of cancer‐related human mortalities. However, it still remains formidable challenge in clinics. Herein, bioinspired multivalent nanoplatform for the highly effective treatment metastatic melanoma reported. The versatile designed by integrating indocyanine green and chemotherapeutic drug (7‐ethyl‐10‐hydroxycamptothecin) into phenylboronic acid (PBA)‐functionalized peptide nanotubes (termed as I/S‐PPNTs). I/S‐PPNTs precisely target tumor...
1D peptide nanostructures (i.e., nanotubes, PNTs) exhibit tunable chemo-physical properties and functions such as improved tissue adhesion, increased cellular uptake, elongated blood circulation. In this study, the application of PNTs a desirable template for biomineralization Cu2-x S nanoparticles (Cu2-x NPs, x = 1-2) is reported. Monodisperse NPs are uniformly coated on nanotubes owing to specific high binding affinity Cu ions imidazole groups exposed surface nanotubes. The NP-coated...
A near-infrared fluorescent probe for MGO imaging in Alzheimer's disease mouse brains was developed.
The accurate detection of tumorous methylglyoxal (MGO) and its detoxifier glyoxalase 1 (GLO1) in living systems is critical for understanding their roles tumor initiation progression. To date, the situ fluorescence endogenous MGO GLO1 has not been reported. Herein we developed a near-infrared (NIR) fluorescent probe MEBTD to specifically detect MGO. Compared with previously reported probes, exhibits several distinct advantages, including NIR emission, high selectivity an limit 18 nM,...
Closely related to multiple chronic inflammation, especially type-2 diabetes (T2D), methylglyoxal (MGO) may be a potential key visualize disease progression and treatment effects. On the other hand, lack of convenient fast analytical methods cannot afford accurate MGO quantitative evaluation. In this work, an activatable second near-infrared region (NIR-II) fluorescent probe TDTCD was synthesized its reaction mechanism with discussed. The desired NIR-II product preferred response solvents...
Stimuli-activatable nanomaterials hold significant promise for tumor-specific drug delivery by recognizing the internal or external stimulus. Herein, we reported a dual-responsive and biodegradable polypeptide nanoparticle (PPTP@PTX2 NP) combinatory chemotherapy photodynamic therapy (PDT) of breast cancer. The NPs were engineered encapsulating diselenide bond linked dimeric prodrug paclitaxel (PTX2) in an intracellular acidity-activatable micelle. Specifically, acid-responsive was...
The processing quality of laser cladding is a topic interest to machine manufacturers. management various experimental data and process the can effectively guide customer better adjust parameters. This study finds that related signal coaxial image. Therefore, this uses learning method establish model image quality. does not merely implement single but also compares algorithms. Convolutional neural networks autoencoders are implemented as algorithms for feature extraction phase. Linear...
In order to explore the application of image recognition model based on multi-stage convolutional neural network (MS-CNN) in deep learning intelligent commodity images and performance method, study, features color, shape, texture are first analyzed, basic structure (CNN) is analyzed. Then, 50,000 pictures containing different commodities constructed verify effect model. Finally, MS-CNN taken as research object for improvement influence label errors (p = 0.03, 0.05, 0.07, 0.09, 0.12) with...