A5042666413- Connective tissue disorders research
- Microbial metabolism and enzyme function
- Macrophage Migration Inhibitory Factor
- Protease and Inhibitor Mechanisms
- Electrospun Nanofibers in Biomedical Applications
- Laser Applications in Dentistry and Medicine
- Retinoids in leukemia and cellular processes
- Complement system in diseases
- Dermatologic Treatments and Research
- Blood Coagulation and Thrombosis Mechanisms
- Advanced X-ray Imaging Techniques
- RNA Research and Splicing
- Platelet Disorders and Treatments
- Skin Protection and Aging
- Wound Healing and Treatments
- Aortic aneurysm repair treatments
- Laser Material Processing Techniques
- Silk-based biomaterials and applications
Fraunhofer Institute for Microstructure of Materials and Systems
2019-2024
Martin Luther University Halle-Wittenberg
2019-2023
Lysyl oxidases (LOXs) play a central role in extracellular matrix remodeling during development and tumor growth fibrosis through cross-linking of collagens elastin. We have limited knowledge the structure substrate specificity these secreted enzymes. LOXs share conserved C-terminal catalytic domain but differ their N-terminal region, which is composed 4 repeats scavenger receptor cysteine-rich (SRCR) domains LOX-like (LOXL) 2. investigated by X-ray scattering electron microscopy...
Elastin is an essential structural protein in the extracellular matrix of vertebrates. It core component elastic fibers, which enable connective tissues such as those skin, lungs or blood vessels to stretch and recoil. This function provided by elastin's exceptional properties, mainly derive from a unique covalent cross‐linking between hydrophilic lysine‐rich motifs units monomeric precursor tropoelastin. To date, poorly investigated. Here, we purified elastin human tissue cleaved it into...
TSP-1 (thrombospondin 1) is one of the most expressed proteins in platelet α-granules and plays an important role regulation hemostasis thrombosis. Interaction released with CD47 membrane receptor has been shown to regulate major events leading thrombus formation, such as, adhesion vascular endothelium, nitric oxide/cGMP (cyclic guanosine monophosphate) signaling, activation as well aggregation. Therefore, targeting TSP-1:CD47 axis may represent a promising antithrombotic strategy. Approach...
Chronic skin wounds place a heavy burden on patients and healthcare systems. To address this problem, we have developed novel composite material consisting of an electrospun fleece free-standing multilayer film that combines the wound healing benefits both materials. In detail combination spray coating electrospinning is used to create layer-by-layer top gelatin fleece, with final thickness about 1 mm. A partially crosslinked in formaldehyde vapor 30 pH-sensitive bonding bilayers oxidized...
Elastin is an essential extracellular matrix protein that enables tissues and organs such as arteries, lungs, skin, which undergo continuous deformation, to stretch recoil. Here, approach fabricating artificial elastin with close-to-native molecular mechanical characteristics described. Recombinantly produced tropoelastin are polymerized through coacervation allysine-mediated cross-linking induced by pyrroloquinoline quinone (PQQ). A technique allows the recovery repeated use of PQQ for...
In recent years, efforts have been made to develop special wound dressings improve the healing of chronic or large area wounds. Elastin-gelatin-based nonwovens and sponges are candidates for these applications. Such materials absorbable possess a microstructure which is appropriate growth biological cells. While suitable fill deeper wounds, nanofiber can cover large-area skin defects. It expected that by introducing microholes into drainage oxygen supply underlying tissue be further...