A5101963843- Plant biochemistry and biosynthesis
- Plant Gene Expression Analysis
- Plant Stress Responses and Tolerance
- Bioinformatics and Genomic Networks
- Plant Reproductive Biology
- Genomics, phytochemicals, and oxidative stress
- Plant Molecular Biology Research
- Plant Water Relations and Carbon Dynamics
- Natural product bioactivities and synthesis
- Plant-derived Lignans Synthesis and Bioactivity
- Computational Drug Discovery Methods
- Advances in Cucurbitaceae Research
- Allelopathy and phytotoxic interactions
- Seed and Plant Biochemistry
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Healthcare Decision-Making and Restraints
- Bioactive natural compounds
- thermodynamics and calorimetric analyses
- Complex Network Analysis Techniques
- Myasthenia Gravis and Thymoma
- Biological Activity of Diterpenoids and Biflavonoids
- Hedgehog Signaling Pathway Studies
- PI3K/AKT/mTOR signaling in cancer
- Seed Germination and Physiology
Soochow University
2025
Soochow University
2021-2024
Northwest A&F University
2016-2023
Central South University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2019
Proanthocyanidins are natural glycosidase inhibitors with excellent antioxidant activity. This study aims to search for a new source of proanthocyanidins the prevention and treatment type 2 diabetes higher content better activity get their structure elucidated. First, total contents (TOPCs), activity, antidiabetic seven common Polygonaceae plants were analyzed compared. Then from rhizome
ABSTRACT Missense mutations in oncogenic proteins that are concurrently associated with neurodevelopmental disorders have garnered significant attention. Phosphatase and tensin homolog (PTEN) serves as a paradigmatic model for mapping its mutational landscape identifying genotypic predictors of distinct phenotypic outcomes, including cancer autism spectrum disorder (ASD). Despite extensive research into the genotype-phenotype correlations PTEN mutations, mechanisms underlying dual...
Hypophosphatasia (HPP) is a rare inherited disorder characterized by defective bone mineralization and highly variable in its clinical phenotype. The disease occurs due to various loss-of-function mutations ALPL, the gene encoding tissue-nonspecific alkaline phosphatase (TNSALP). In this work, data-driven biophysics-based approach proposed for large-scale analysis of ALPL mutations-from nonpathogenic severe HPPs. By using pipeline synergistic approaches including sequence-structure analysis,...
Schisandra sphenanthera is an extremely important medicinal plant, and its main component bioactive lignans. The S. fruit preferred by the majority of consumers, root, stem, leaf are not fully used. To better understand lignan metabolic pathway, transcriptome metabolome analyses were performed on four major tissues sphenanthera. A total 167,972,229 transcripts 91,215,760 unigenes with average length 752 bp identified. Tissue-specific gene analysis revealed that root had highest abundance...
DNA methyltransferases (DNMTs) including DNMT1 are a conserved family of cytosine methylases that play crucial roles in epigenetic regulation. The versatile functions rely on allosteric networks between its different interacting partners, emerging as novel therapeutic targets. In this work, based the modeling structures DNMT1-ubiquitylated H3 (H3Ub)/ubiquitin specific peptidase 7 (USP7) complexes, we have used combination elastic network models, molecular dynamics simulations, structural...
Structure, network modeling and dynamic spectrum of C. militaris sugar transporters were investigated. An allosteric site (H1 region) which guided pathways between this region the channel cavity was identified in Hex subfamily.
To research the expression of key enzymes in saikosaponin biosynthesis and content under drought stress, study focused on gene-level end product responses to environmental change. Taking five months Bupleurum chinense as materials, contents A D different stress levels were measured by HPLC. The was simulated poly ethylene glycol. real-time fluorescence quantitative PCR used analyze four genes HMGR, IPPI, FPS, β-AS β-tubulin set a reference gene. results showed that significantly improved...
Artemisia scoparia, sacrorum and giraldii were three dominant species which successive grew in the secondary succession on abandoned land of Loess Plateau. The accompanied soil moisture steady decrease with field age after their abandonment. To elucidate relationship between drought-adaptation, a contrastive annua (mesophyte), selected to compare drought-resistant characteristics, including morphological anatomical traits leaf root. Then physiological responses investigated mature plants...
Pharmacognosy Magazine,2018,14,56,425-431.DOI:10.4103/pm.pm_408_17Published:August 2018Type:Original ArticleAuthors:Hongyu Xu, Ziyun Zhou, Juane Dong, and Ming Lei Author(s) affiliations:Hongyu College of Life Sciences, Northwest A&F University, Yangling, Shaanxi 712100, China Abstract:Background: Previous phytochemical studies showed that extracts from leaves seed oil Catalpa plants antioxidant antitumor activities. However, the active components their roles molecular mechanisms were still...
Our previous study finds that male sterility in Salvia miltiorrhiza could result stunted growth and reduced biomass, but their molecular mechanisms have not yet been revealed. In this article, we investigate the underlying mechanism of its impact on plant metabolic yield by using physiological analysis mRNA sequencing (RNA-Seq).In study, transcriptomic were performed to identify mutants yield. Through Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) analysis, it is found pathways...
In the post-COVID-19 era, treatment options for potential SARS-CoV-2 outbreaks remain limited. An increased incidence of central nervous system (CNS) disorders has been observed in long-term COVID-19 patients. Understanding shared molecular mechanisms between these conditions may provide new insights developing effective therapies. This study developed an integrative drug-repurposing framework COVID-19, leveraging comorbidity data with CNS disorders, network-based modular analysis, and...
Abstract Schisandra sphenanthera is an very important medicinal plant, and its main component bioactive lignans, which has been developed over the years as cash crop in central mountainous. The S. fruit characteristics of food medicine homology, favored by majority consumers, but root, stem, leaf are not fully used. Furthermore, genetic rarely understood, thus hindering study functional genome lignan biosynthesis. To better understand metabolic pathway, transcriptome metabolome analysises...