A5030099283- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- CAR-T cell therapy research
- Galectins and Cancer Biology
- Immunotherapy and Immune Responses
- Cytomegalovirus and herpesvirus research
- Cell Adhesion Molecules Research
Australian Regenerative Medicine Institute
2019-2024
Monash University
2019-2024
Australian Research Council
2019-2021
A different way for γδ T cells to bind The ligands bound by cell receptors (TCRs) are less well characterized than those of their αβ TCR cousins, which antigens presented major histocompatibility complex (MHC) and related proteins. Le Nours et al. identified a phenotypically diverse subset in human tissues that reacts MHC-related protein 1 (MR1), presents vitamin B derivatives. crystal structure TCR–MR1–antigen revealed some these TCRs can underneath the MR1 antigen-binding cleft instead...
Significance Alongside αβ T cells and B cells, γδ comprise a major component of the adaptive immune system, although lack bona fide ligands has hindered understanding their function. are key mediators epithelial surveillance have purported capacity for employing diverse ligand engagement mechanisms beyond dogmas conventional cell–human leukocyte antigen restriction. Here, we found blood- gut-resident Vδ1/2 − bound to MR1 tetramers in metabolite-independent mechanism distinct from...
T cells in jawed vertebrates comprise two lineages, αβ and γδ cells, defined by the antigen receptors they express-that is, cell (TCRs), respectively. The lineages have different immunological roles, requiring that TCRs recognize more structurally diverse ligands
αβ T cell receptors (αβTCRs) co-recognise antigens when bound to Major Histocompatibility Complex (MHC) or MHC class I-like molecules. Additionally, some αβTCRs can bind non-MHC molecules, but how much intact antigen reactivities are achieved remains unknown. Here, we identify an clone that directly recognises the foreign protein, R-phycoerythrin (PE), a multimeric (αβ)6γ protein complex. This direct αβTCR–PE interaction occurs in MHC-independent manner, yet triggers activation and PE with...
In this article, we discuss recent advances into the structural analyses of immunoglobulin M complexes, which are enabling comprehensive characterization these enigmatic antibodies, to reveal central tenets immunobiology and inform their immunotherapeutic use.