A5060038491- DNA Repair Mechanisms
- Genetic Neurodegenerative Diseases
- Bioinformatics and Genomic Networks
- Genetic Associations and Epidemiology
- Integrated Circuits and Semiconductor Failure Analysis
- Facial Trauma and Fracture Management
- Microtubule and mitosis dynamics
- Microbial Metabolic Engineering and Bioproduction
- Orthopedic Surgery and Rehabilitation
- CAR-T cell therapy research
- Facial Rejuvenation and Surgery Techniques
- Facial Nerve Paralysis Treatment and Research
- Dupuytren's Contracture and Treatments
- Adolescent and Pediatric Healthcare
- Mitochondrial Function and Pathology
- Advancements in Semiconductor Devices and Circuit Design
- Fungal and yeast genetics research
- Bipolar Disorder and Treatment
- RNA Research and Splicing
University of Maryland, Baltimore
2024
Stanford University
2007-2022
United States Department of Health and Human Services
2020-2021
National Institute of Mental Health
2020-2021
National Institutes of Health
2020
Johns Hopkins University
2018
Princeton University
2007
The Saccharomyces Genome Database (SGD; http://www.yeastgenome.org/) collects and organizes biological information about the chromosomal features gene products of budding yeast cerevisiae. Although published data from traditional experimental methods are primary sources evidence supporting Gene Ontology (GO) annotations for a product, high-throughput experiments computational predictions can also provide valuable insights in absence an extensive body literature. Therefore, GO available at...
Abstract Expansion of a single repetitive DNA sequence, termed tandem repeat (TR), is known to cause more than 50 diseases 1,2 . However, expansions are often not explored beyond neurological and neurodegenerative disorders. In some cancers, mutations accumulate in short tracts TRs, phenomenon microsatellite instability; however, larger have been systematically analysed cancer 3–8 Here we identified TR 2,622 genomes spanning 29 types. seven types, found 160 recurrent (rREs), most which...
Despite strong evidence of heritability and growing discovery genetic markers for major mental illness, little is known about how gene expression in the brain differs across psychiatric diagnoses, or risk factors shape these differences. Here we investigate expressed genes transcripts postmortem subgenual anterior cingulate cortex (sgACC), a key component limbic circuits linked to illness. RNA obtained from 200 donors diagnosed with bipolar disorder, schizophrenia, depression, no disorder...
Managing large B-cell lymphoma (LBCL) that is refractory to or relapsed after chimeric antigen receptor (CAR)-T therapy remains a significant challenge. Here we aimed investigate the safety and efficacy of C-CAR066, an autologous fully human anti-CD20 specific CAR-T, for relapsed/refractory LBCL failure anti-CD19 CAR-T therapy. This first-in-human, single-arm, phase 1 study was conducted at two sites in China. Eligible patients had be histologically confirmed with CD20-positive must have...
<i>Background</i>: Dupuytren’s contracture is a fibroproliferative disorder that often results in contractions of the fourth and fifth digits hand. While there no definitive cure, symptomatic relief can be achieved via open fasciotomy, percutaneous aponeurotomy, or through collagenase <i>Clostridium Histolyticum</i> injections (CCH). Despite these therapeutic options, insurance coverage modalities not clearly defined....
Abstract Expansion of a single repetitive DNA sequence, termed tandem repeat (TR), is known to cause more than 50 diseases. However, expansions are often not explored beyond neurological and neurodegenerative disorders. In some cancers, mutations accumulate in short tracts TRs (STRs), phenomenon microsatellite instability (MSI); however larger have been systematically analyzed cancer. Here, we identified TR 2,622 cancer genomes, spanning 29 types. 7 types, found 160 recurrent (rREs); most...