A5101469720- Neurological Disorders and Treatments
- Renal and related cancers
- Medicinal Plants and Bioactive Compounds
- Computational Drug Discovery Methods
- Tryptophan and brain disorders
- Sarcoma Diagnosis and Treatment
- Ultrasound and Hyperthermia Applications
- Venous Thromboembolism Diagnosis and Management
- Renal and Vascular Pathologies
- Pharmacological Effects of Natural Compounds
- Flavonoids in Medical Research
- Traditional Chinese Medicine Studies
- Coronary Interventions and Diagnostics
- Cholinesterase and Neurodegenerative Diseases
- Pancreatic function and diabetes
- Protease and Inhibitor Mechanisms
- Cardiovascular Disease and Adiposity
- Phytochemical Studies and Bioactivities
- Natural product bioactivities and synthesis
- Plant-based Medicinal Research
- Neurogenetic and Muscular Disorders Research
- Gut microbiota and health
- Autism Spectrum Disorder Research
- Traditional and Medicinal Uses of Annonaceae
- Tumors and Oncological Cases
Guang’anmen Hospital
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Ningbo No. 2 Hospital
2022-2023
Beijing University of Chinese Medicine
2017-2022
Ningbo University
2018
Comprehensive Summary Thrombosis, secondary to rupture of unstable plaque, is a fatal risk factor for myocardial infarction and ischemic stroke. At present, more novel methods are needed the diagnosis treatment vulnerable plaque. Here, we report hollow polydopamine/Zn (HPDA/Zn) ultrasound contrast agent. Through western‐blot, Elisa, other experiments, found that in addition having good contrast‐enhancement capability imaging vitro vivo , HPDA/Zn also has effect reducing expression CREB. CREB...
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with poorly understood etiology. Recent studies have suggested that metabolic dysregulation might be linked to the development of ASD; however, causal relationships remain unclear. This study aimed investigate association between these factors using two-sample Mendelian randomization (TSMR). We conducted TSMR analysis assess relationship blood metabolites and ASD summarized GWAS data. The metabolite dataset from...
Tiansi Liquid is a traditional Chinese herbal medicine used to treat depression; however, the underlying mechanisms remain unclear. Here, we examined effect of in rat model hydrocortisone-induced depression using behavioral testing, 16S rRNA high-throughput pyrosequencing and high-performance liquid chromatography-mass spectrometry-based metabolomics tryptophan (TRP)⁻kynurenine (KYN) pathway. significantly improved sucrose preference exploratory behavior depressive rats. The richness...
The 5-hydroxytryptamine (5-HT) and dopamine (DA) receptors have emerged as significant targets for therapeutic intervention in psychiatric disorders. Currently, the efficacy of drugs is limited by challenges achieving desired outcomes, occurrence adverse effects, dependence, withdrawal reactions. Consequently, there a pressing need development safe effective agents To explore potential effects natural product extracts disorders, 73 active ingredients from medicine were screened to identify...
Purpose: Depression is a sickening psychiatric condition that prevalent worldwide. To manage depression, the underlying modes of antidepressant effect herbals are important to be explored for development natural drugs. Tiansi Liquid traditional Chinese medicine (TCM) prescribed management however its mechanism action still uncertain. The purpose this study was systematically investigate pharmacological mode herbal formula used in TCM treatment depression. Methods: Based on literature search,...
Background: So far, only a few researchers have systematically analyzed the constituents of traditional Chinese medicine prescription Xixin Decoction (XXD) and its potential mechanism action in treating Alzheimer’s disease (AD). This study aimed to explore XXD treatment AD using network pharmacology molecular docking. Methods: The compounds were searched within Traditional Medicine System Pharmacology Database (TCMSP) Integrated (TCMID) databases. Overlapping AD-related targets obtained from...
Purpose: To review the chemical constituents, and pharmacological toxicological effects of Cynomorium songaricum (C. songaricum) explore its potentials for further development as an alternative medicine.Methods: A large number research articles related to "Cynomorium songaricum" "pharmacological effects", "toxicological effects" "chemical composition" in English Chinese language were retrieved through extensive literature using various electronic databases including Medline(1966 - 2017)...
Traditional Chinese medicine (TCM) syndrome differentiation, as the core of traditional medical system, has played an indispensable role in guaranteeing health nation for thousands years.Recently, with collaborative promotion multiple departments, TCM technology innovation capability China been continuously enhanced.The integration differentiation artificial intelligence AI, big data, and other fields made new progress.Engineering frontier methods technologies have provided effective route...
Abstract Background: Alzheimer's disease (AD) is characterized by progressive cognitive decline. Behavioral and psychological symptoms in dementia (BPSD) are another critical characterization of AD besides deficit. However, the pharmacological treatment BPSD remains challenging. HuanglianJiedu decoction (HLJDD), which consists four herbs, applied to treat traditional Chinese medicine, especially with BPSD. While frequently used compatibility HLJDD, whose principal ingredient Coptidis Rhizoma...
Objective To investigate the feasibility of using ultrasound-mediated destruction microbubbles (US+ MB) to enhance transplantation endothelial progenitor cells(EPCs) confer chronic allograft vasculopathy (CAV). Methods Bone marrow derived mononuclear cells were isolated and induced in vitro. The abdominal aorta was performed. Four groups divided: control group without treatment (group A), injection with saline B), EPCs C), D MB+ EPCs) injected US applied MB prior infusion. All rats...
Objective To explore the value of three-dimensional (3D) sonography in evaluation developmental dysplasia hip (DDH).Methods From June 2010 to December 2010,768newborns were screened by two-dimensional combined with 3D high-fiequency linear array detector.And newborns younger than 7 days are method Graf and femoral coverage ratio measurement,combined image,to judge development.Results Out 768 newborn (398 females 370 males,average 5.8 days),there 1 412 normal hip(91.92％),99 unstable...
Objective To evaluate the relationship between atrial synchrony and paroxysmal fibrillation (PAF) in patients with sick sinus syndrome (SSS) by two-dimensional speckle tracking imaging. Methods Forty-four SSS who underwent echocardiographic examination at Department of Ultrasound, No. 2 Hospital Yinzhou Ningbo City Zhejiang Province from January 2015 to August 2016 were enrolled, including 25 without PAF 19 PAF. Twenty-eight normal adults this department same time included as a...
Abstract Along with cognitive deficit, behavioral and psychological symptoms in dementia (BPSD) is another characteration of Alzheimer's disease that hamper clinical management exacerbate burden for caregivers. However, therapeutic BPSD remains challenging. HuanglianJiedu decoction (HLJDD), a traditional Chinese prescription which contains Coptidis rhizome (Huang lian), Scutellariae radix (Huang-qin), Phellodendri chinrnsis cortex (Huang-bai) Gardeniae fructus (Zhi-zi), applied to treat...
Abstract Alzheimer's disease (AD) is characterized by progressive cognitive decline. Besides deficit, AD also behavioral and psychological symptoms in dementia (BPSD). However, therapeutic management of BPSD remains challenging. HuanglianJiedu decoction (HLJDD), a traditional Chinese prescription, consisting four herbs, applied to treat AD, especially with BPSD. Though HLJDD, has the combination principal herb Coptidis rhizoma (Huang-lian), it might, however, not be suitable for treating...