A5043432962- Acute Ischemic Stroke Management
- Visual perception and processing mechanisms
- HIV-related health complications and treatments
- Neuroscience and Neuropharmacology Research
- Retinal Development and Disorders
- Stroke Rehabilitation and Recovery
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Complications and Syndromes
- Intracranial Aneurysms: Treatment and Complications
- Glaucoma and retinal disorders
- Receptor Mechanisms and Signaling
- Neurological and metabolic disorders
- Adenosine and Purinergic Signaling
- Retinal Imaging and Analysis
- Cardiac electrophysiology and arrhythmias
- Moyamoya disease diagnosis and treatment
- Cerebrovascular and Carotid Artery Diseases
- Protein Kinase Regulation and GTPase Signaling
- Cardiac Imaging and Diagnostics
- HIV Research and Treatment
- Protein Tyrosine Phosphatases
- Plant Pathogens and Fungal Diseases
- Regulation of Appetite and Obesity
- Cellular transport and secretion
- Retinal and Macular Surgery
University of Rochester
2016-2024
University of Rochester Medical Center
2013-2020
Baden-Wuerttemberg Cooperative State University
2016
Johns Hopkins University
2013
Johns Hopkins Medicine
2013
The University of Texas Southwestern Medical Center
2004-2007
Sleep homeostasis reflects a centrally mediated drive for sleep, which increases during waking and resolves subsequent sleep. Here we demonstrate that mice deficient glial adenosine kinase (AdK), the primary metabolizing enzyme (Ado), exhibit enhanced expression of this homeostatic by three independent measures: (1) increased rebound slow-wave activity; (2) consolidation sleep; (3) time constant activity decay an average sleep episode, proposed validated here as new index drive. Conversely,...
The question of whether viruses persist after apparent clearance infection remains unanswered. Here, we describe a patient with hypogammaglobulinemia whose acute hepatitis C virus (HCV) appeared to resolve receipt interferon therapy, relapse immediately, and then clear spontaneously—only corticosteroid again, 8.5 years later. Sequencing indicated that the detected during each were virtually identical, hypervariable region 1 E2 appearing be monoclonal, which is typical patients...
Damage to the optic radiations or primary visual cortex leads blindness in all part of contralesional field. Such damage disconnects retina from its downstream targets and, over time, trans-synaptic retrograde degeneration retinal ganglion cells. To date, ability is only predictor cell that has been investigated after geniculostriate damage. Given prior findings some patients have preserved activity for stimuli presented their blind field, we tested whether explains variability and above...
Background Following cryptogenic stroke, guidelines recommend cardiac monitoring for occult atrial fibrillation (AF). We aimed to evaluate predictors of AF during long‐term implantable monitoring. Methods and Results studied 293 consecutive patients who underwent monitor implant (Medtronic LINQ) following hospitalization stroke at the University Rochester Medical Center from January 2013 September 2018. Multivariable Cox proportional hazards regression modeling was used identify At 36 months...
The regulation of adenosine kinase (AK) activity has the potential to control intracellular and interstitial (Ado) concentrations. In an effort study role AK in Ado homeostasis central nervous system, two isoforms enzyme were cloned from a mouse brain cDNA library. Following overexpression bacterial cells, corresponding proteins purified homogeneity. Both enzymatically active found possess K m V max values agreement with kinetic parameters described for other forms AK. distribution discrete...
Inhibitor-1 becomes a potent inhibitor of protein phosphatase 1 when phosphorylated by cAMP-dependent kinase at Thr(35). Moreover, Ser(67) inhibitor-1 serves as substrate for cyclin-dependent 5 in the brain. Here, we report that dephosphoinhibitor-1 but not phospho-Ser(67) was efficiently C Ser(65) vitro. In contrast, phosphorylation unaffected phospho-Ser(65). Protein activation striatal tissue resulted concomitant and Ser(67), alone. Selective pharmacological inhibition activity suggested...
Rationale: We provide an in-depth description of a comprehensive clinical, immunological, and neuroimaging study that includes full image processing pipeline. This approach, although implemented in HIV infected individuals, can be used the general population to assess cerebrovascular health. Aims: In this longitudinal study, we seek determine effects neuroinflammation due HIV-1 infection on pathomechanisms cerebral small vessel disease (CSVD). The focuses interaction activated platelets,...
The aim of this study was to assess, in the context cerebral small vessel disease (CSVD), whether cardiovascular risk factors and white matter hyperintensities (WMHs) were associated with brain tissue susceptibility as measured by quantitative mapping (QSM). Given that CSVD is diagnosed presence lacunar strokes, periventricular deep WMHs, increased perivascular spaces, microbleeds, we expected QSM could capture changes due underlying pathology. We compared a cohort 101 HIV-infected...
Patients with symptomatic internal carotid artery (ICA) occlusion constitute a small proportion of stroke/transient ischaemic attack patients who are at increased risk early stroke recurrence and poor outcome. The optimal medical treatment for ICA ineligible thrombolysis or thrombectomy is unknown.Consecutive presenting single center newly diagnosed (not involving the circle Willis) were retrospectively reviewed. Those treated intravenous intra-arterial thrombolysis/thrombectomy excluded....
Despite antiretroviral treatment (cART), aging people living with HIV (PWH) are more susceptible to neurocognitive impairment (NCI) probably due synergistic/additive contribution of traditional cerebrovascular risk factors. Specifically, transmigration inflammatory CD16+ monocytes through the altered blood brain barrier (BBB) may exacerbate cerebral small vessel disease (CSVD), a known cause vascular cognitive impairment.
Damage to the optic radiations or primary visual cortex leads blindness in all part of contralesional field. Such damage disconnects retina from its downstream targets and, over time, trans-synaptic retrograde degeneration retinal ganglion cells. To date, ability is only predictor cell that has been investigated after geniculostriate damage. Given prior findings some patients have preserved activity for stimuli presented their blind field, we tested whether this explains variability and...
The division of labour between the dorsal and ventral visual pathways is well established. stream supports object identification, while online processing information in service visually guided actions. Here, we report a case an individual with right inferior quadrantanopia who exhibited accurate spontaneous rotation his wrist when grasping target blind field. His orientation was observed despite fact that he no sensitivity to handle perceptual matching task. These findings indicate...
Unruptured intracranial aneurysms are common. Rupture is rare, but associated with considerable morbidity and mortality. Screening for unruptured indicated in certain patient populations, many patients request screening outside of established guidelines. In addition, may be discovered incidentally. The presence an aneurysm has a negative effect the seeking life insurance. This commentary provides perspective on insurance underwriting individuals offers points clinicians to consider when...
ABSTRACT Despite antiretroviral treatment (cART), people living with HIV (PLWH) are more susceptible to neurocognitive impairment (NCI), probably due synergistic/additive contribution of traditional cerebrovascular risk factors. Specifically, altered blood brain barrier (BBB) and transmigration inflammatory monocytes factors for developing cerebral small vessel disease (CSVD). In order investigate if exacerbate CSVD cognitive impairment, 110 PLWH on cART age-, sex- Reynold’s cardiovascular...
Approximately one-third of stroke patients suffer visual field impairment as a result their strokes. However, studies using the pathway paradigm for studying poststroke recovery are limited. In this article, we propose that has many features make it an excellent model system neuroplasticity and assessing efficacy therapeutic interventions. First, functional anatomy is well characterized, which makes suited neuroimaging recovery. Second, there multiple highly standardized clinically available...
Post-stroke homonymous hemianopia is disabling and complete spontaneous recovery rare (12.5%). Other than acute revascularization, no proven treatments are available to enhance recovery. Compensatory training may lead modest functional improvements, but does not restore native function. As such, therapies effective beyond the stage desperately needed. In this phase IIa single-center, double-blinded, randomized, placebo-controlled pilot clinical trial, we tested whether fluoxetine (FLX)...
Background/Objectives: Current options for early intervention in acute ischemic stroke (AIS) include intravenous tissue plasminogen activator (IV-tPA) and/or intra-arterial (IA) therapy eligible patients. While there are well-defined indications and contraindications IV-tPA, similar guidelines have not emerged IA-therapy. The resulting practice variability may partly explain why IA-therapy continues to represent only a small fraction of overall AIS interventions. Methods: This is prospective...
Stroke in the territory of posterior cerebral artery leads to cortical blindness a hemifield or quadrant contralesional visual field. While about 50% patients experience some degree recovery within first 6 months post-stroke, only 12.5% complete (Tiel K., Kolmel, 1990). One limiting factor that may prevent further is trans-synaptic retrograde degeneration retinal ganglion cells, which has been observed stroke starting as early 3 after (Jindahra, Petrie, & Plant, 2009, 2012; Park, Cho, 2013;...