A5035747711- HIV-related health complications and treatments
- HIV Research and Treatment
- Atherosclerosis and Cardiovascular Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Single-cell and spatial transcriptomics
- Pneumocystis jirovecii pneumonia detection and treatment
- Cardiovascular Disease and Adiposity
- Osteoarthritis Treatment and Mechanisms
- Periodontal Regeneration and Treatments
- Immune Cell Function and Interaction
- Mesenchymal stem cell research
- Cytomegalovirus and herpesvirus research
- Adipokines, Inflammation, and Metabolic Diseases
- Immune cells in cancer
- Neurological Complications and Syndromes
- Cancer, Lipids, and Metabolism
University of Rochester
2018-2024
Southern California Clinical and Translational Science Institute
2022
The University of Texas MD Anderson Cancer Center
2017
Osiris Therapeutics (United States)
2005
The incidence of cardiovascular disease is higher in HIV-positive (HIV+) patients than it the average population, and combination antiretroviral therapy (cART) a recognized risk factor for disease. However, molecular mechanisms that link cART are currently unknown. Our study explores role activation p90RSK, reactive oxygen species-sensitive kinase, engendering senescent phenotype macrophages accelerating atherogenesis undergoing cART.Peripheral whole blood from cART-treated HIV+ individuals...
Despite antiretroviral treatment (cART), aging people living with HIV (PWH) are more susceptible to neurocognitive impairment (NCI) probably due synergistic/additive contribution of traditional cerebrovascular risk factors. Specifically, transmigration inflammatory CD16+ monocytes through the altered blood brain barrier (BBB) may exacerbate cerebral small vessel disease (CSVD), a known cause vascular cognitive impairment.
Atherosclerosis (AS)-associated cardiovascular disease is an important cause of mortality in aging population people living with HIV (PLWH). This elevated risk has been attributed to viral infection, anti-retroviral therapy, chronic inflammation, and lifestyle factors. However, the rates at which PLWH develop AS vary even after controlling for length treatment duration, To investigate molecular signaling underlying this variation, we sequenced 9368 peripheral blood mononuclear cells (PBMCs)...
Abstract Background In people living with HIV (PLWH) on combination antiretroviral therapy (cART), persistent systemic inflammation is a driving force for the progression of comorbidities, such as cardiovascular and cerebrovascular diseases. this context, monocyte- macrophage-related rather than T cell activation major cause chronic inflammation. However, underlying mechanism how monocytes in PLWH elusive. Methods Results vitro, we demonstrated that lipopolysaccharides (LPS) or tumor...
Abstract People living with HIV are at higher risk of atherosclerosis (AS). The pathogenesis this is not fully understood. To assess the regulatory networks involved in AS we sequenced mRNA peripheral blood mononuclear cells (PBMCs) and measured cytokine chemokine levels plasma 13 persons 12 matched HIV-negative without AS. microRNAs (miRNAs) known to play a role infection may modulate gene regulation drive Hence, further assessed miRNA expression PBMCs subset HIV+ people atherosclerosis. We...
ABSTRACT Despite antiretroviral treatment (cART), people living with HIV (PLWH) are more susceptible to neurocognitive impairment (NCI), probably due synergistic/additive contribution of traditional cerebrovascular risk factors. Specifically, altered blood brain barrier (BBB) and transmigration inflammatory monocytes factors for developing cerebral small vessel disease (CSVD). In order investigate if exacerbate CSVD cognitive impairment, 110 PLWH on cART age-, sex- Reynold’s cardiovascular...
Introduction Due to advances in combined anti-retroviral treatment (cART), there is an increased burden of age-related cerebrovascular disease (CBVD), people living with HIV (PWH). The underlying CNS injury can be assessed by measuring cerebral blood flow (CBF) and reactivity (CVR). Methods 35 treatment-naïve PWH 53 negative controls (HC) were enrolled this study. Study participants underwent T1-weighted anatomical, pseudo-continuous arterial spin labeling, resting-state functional MRI...
Abstract Atherosclerosis (AS)-associated cardiovascular disease is an important cause of mortality in aging population people living with HIV (PLWH). This elevated risk has been attributed to viral infection, anti-retroviral therapy, chronic inflammation, and lifestyle factors. However, rates at which PLWH develop AS vary even after controlling for length treatment duration, To investigate the molecular signaling underlying this variation, we sequenced 9368 peripheral blood mononuclear cells...
Background: In HIV patients on combination antiretroviral therapy (cART), persistent systemic inflammation is a driving force for the progression of comorbidities, such as cardiovascular diseases. Monocyte and macrophage-related rather than T cell activation major cause chronic inflammation. However, underlying mechanism how monocytes multifaceted. Methods Results: vitro, we demonstrated that lipopolysaccharides (LPS) or tumor necrosis factor alpha (TNFα), induced robust increase Delta-like...
Background: Increased incidence of cardiovascular disease (CVD) in HIV patients has been established, but the consequence anti-HIV therapies CVD is unclear. The activation p90RSK endothelial cells a critical event atherosclerosis, its role macrophage unknown. Hypothesis: plays drug-induced and atherosclerosis. Methods Results: In macrophages, efferocytosis-related signaling was upregulated inflammatory gene expression down-regulated activity-dependent manner. Using Lysm-Cre dominant negative...
Increased cardiovascular (CV) events in HIV patients and cancer survivors the fact that combination antiretroviral therapy (cART) chemotherapy induce similar unwanted CV effects are becoming evident, but reason for this is unclear. In study, we examined role of p90RSK toxicity cART anti-cancer drugs. The level activation by H2O2 was higher peripheral monocytes from cART-treated than those untreated patients. Multiple linear regression analysis involving HIV+/-, Reynolds risk score, basal...