A5101802481- Ovarian cancer diagnosis and treatment
- Peroxisome Proliferator-Activated Receptors
- Reproductive Biology and Fertility
- Mitochondrial Function and Pathology
- Ovarian function and disorders
- Cellular transport and secretion
- Family Support in Illness
- Poisoning and overdose treatments
- Acute Lymphoblastic Leukemia research
- Metabolomics and Mass Spectrometry Studies
- RNA Research and Splicing
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Bioinformatics and Genomic Networks
- Plant and fungal interactions
- Genomics and Rare Diseases
- Long-Term Effects of COVID-19
- Advanced Proteomics Techniques and Applications
- Childhood Cancer Survivors' Quality of Life
- Metabolism, Diabetes, and Cancer
- Autophagy in Disease and Therapy
- RNA modifications and cancer
- Suicide and Self-Harm Studies
- Renal cell carcinoma treatment
- Endometrial and Cervical Cancer Treatments
- Fungal and yeast genetics research
DR. B.R.A. Institute Rotary Cancer Hospital
2000-2022
All India Institute of Medical Sciences
2000-2022
All India Institute of Medical Sciences Bhopal
2022
University of Groningen
2019-2020
Czech Academy of Sciences, Institute of Psychology
2020
Women & Infants Hospital of Rhode Island
2014
Brown University
2014
Saccharomyces cerevisiae glycerol phosphate dehydrogenase 1 (Gpd1) and nicotinamidase (Pnc1) are two stress-induced enzymes. Both enzymes predominantly localised to peroxisomes at normal growth conditions, but were reported localise the cytosol nucleus upon exposure of cells stress. Import both proteins into depends on peroxisomal targeting signal 2 (PTS2) receptor Pex7. Gpd1 contains a PTS2, however, Pnc1 lacks this sequence. Here we show that physically interacts with Gpd1, which is...
5531 Background: To determine the impact of NACT on surgical debulking rate, overall and disease-free survival quality life (QOL) in patients with advanced EOC. Methods: Between Oct 2001 Dec 2006, 128 previously untreated EOC (median age- 50 years, range 30 to 65) FIGO stage III C & IV (pleural effusion only) have been randomized into - Arm A (n=65) upfront Surgery followed by 6 cycles Paclitaxel carboplatin (PC) B (n=63): 3 PC then more cycles. Eligibility criteria include age 18 65...
Here, we describe a novel peroxin, Pex37, in the yeast Hansenula polymorpha . H. Pex37 is peroxisomal membrane protein, which belongs to protein family that includes, among others, Neurospora crassa Woronin body Wsc, human PXMP 2, Saccharomyces cerevisiae mitochondrial inner Sym1, and its mammalian homologue MPV 17. We show deletion of PEX 37 does not appear have significant effect on peroxisome biogenesis or proliferation cells grown at peroxisome‐inducing growth conditions (methanol)....
5123 Background: To determine the impact of NACT on surgical debulking rate, overall and disease-free survival quality life. Methods: Between Oct 2001 Dec 2003, 43 previously untreated patients (median age- 50 years, range 30–65) with FIGO stage III C & IV were randomized into two arms; Arm A (n=22) upfront Sx followed by 6 cycles paclitaxel carboplatin (TC). In B (n=21) received 3 TC more cycles. Eligibility criteria included –age 18 to 65 biopsy / cytological proven diagnosis EOC, adequate...
15000 Background: We compared upfront surgery to chemotherapy in patients with advanced EOC (stage IIIC and IV (pleural effusion only). Factors- optimum debulking (residual disease ≤1cm) rate, surgical morbidity, toxicity, survival quality of life (QOL) were analyzed. Methods: Between Oct.2001 Oct. 2005, 90 newly diagnosed have been randomized followed by six cycles paclitaxel + carboplatin (TC) (Arm A) or - 3 then more TC. Eligibility criteria included- age 18 65 years, biopsy cytological...
Saccharomyces cerevisiae Vac8 is a vacuolar membrane protein, which functions in vacuole inheritance and fusion, nucleus-vacuole junctions, autophagy the cytoplasm-to-vacuole-targeting pathway. Here, we analyzed of yeast Hansenula polymorpha. We show that HpVac8 localizes to concentrates patches at junctions. Analysis VAC8 deletion strain indicated required for formation nuclear-vacuole but not fusion. Previously, organelle proteomics resulted identification peroxisomal fractions isolated...
Abstract Objective: Prognosis of patients with recurrent epithelial ovarian cancer (EOC) is generally poor. Cisplatin the most effective drug. We used three cisplatin based chemotherapeutic (CT) regimens and retrospectively analyzed data to determine response rate, toxicity, survival impact various prognostic factors on outcome. Patients Methods: Between August, 1989 September, 1997, 102 were diagnosed have EOC. Sixty‐five received CT every 3 weeks using 75 mg/m 2 IV day 1 plus...
We explored the link between mitochondrial biogenesis and morphology using transmission electron microscopy (TEM) in lymphoblasts of pediatric acute lymphoblastic leukemia (ALL) patients compared these characteristics tumors control samples. Gene expression markers was analysed 23 ALL 18 controls TEM for analysis done 15 9 healthy controls. The area occupied by mitochondria per cell cristae cross-sectional observed to be significantly higher than (p-value = 0.0468 p-value< 0.0001,...
To fill the gap in patient-reported outcome (PRO) assessment children with cancer India, we planned to adapt domains from HealthMeasures Patient Reported Outcomes Measurement Information System (PROMIS) tool. This study attempted identify and pool outcomes relevant their caregivers Northern India.The was qualitative conducted through focussed group discussions (FGDs) in-depth interviews of caregivers. Content analysis transcripts sessions done. The collected themes were collated existing...
Abstract Background Research on the role of variations in mitochondrial genome pathogenesis acute lymphoblastic leukemia (ALL) has been unfolding at a rapid rate. Our laboratory previously described higher number copies genomes per cell pediatric ALL patients as compared to healthy controls. In current study, we evaluated pattern 20 de-novo B-ALL cases and seven Quantitative real-time Polymerase Chain Reaction was used for estimation genomes’ copy bone marrow samples each patient peripheral...
Abstract Background Self-injurious thoughts and behaviours (SITBs) include a spectrum of self-harming that an individual may choose to engage in - one such behaviour is labelled as Non-Suicidal Self-Injury (NSSI). The current study was carried out assess the epidemiological factors associated with NSSI, regarded clinical disorder included under Conditions for Further Study DSM-5 , explore its association borderline personality traits. Additionally, it also aimed at assessing reasons why...