A5101958578- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Plant Toxicity and Pharmacological Properties
- Reproductive Health and Contraception
- Fatty Acid Research and Health
- Pregnancy and Medication Impact
- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Drug-Induced Hepatotoxicity and Protection
- Reproductive System and Pregnancy
- Pancreatic function and diabetes
- Gestational Diabetes Research and Management
- Skin Protection and Aging
- Diet and metabolism studies
- Drug Transport and Resistance Mechanisms
- Diabetes and associated disorders
- DNA and Biological Computing
- thermodynamics and calorimetric analyses
- Pharmacogenetics and Drug Metabolism
- Liver Disease and Transplantation
- Error Correcting Code Techniques
- Metabolomics and Mass Spectrometry Studies
- Prenatal Substance Exposure Effects
- Genomics, phytochemicals, and oxidative stress
- Market Dynamics and Volatility
Wuhan University
2015-2025
Hubei Provincial Center for Disease Control and Prevention
2017-2024
Communication University of China
2020-2023
State Key Laboratory of Hybrid Rice
2022
Guiyang Medical University
2018
Shenyang Pharmaceutical University
2018
Hunan University of Finance and Economics
2017
Chang Hua Hospital
2016-2017
SAIC-GM (China)
2015
Dong-A University Hospital
2015
Upon sensing cytosolic DNA, the enzyme cGAS induces innate immune responses that underpin anti-microbial defenses and certain autoimmune diseases. Missense mutations of PRKDC encoding DNA-dependent protein kinase (DNA-PK) catalytic subunit (DNA-PKcs) are associated with diseases, yet how DNA-PK deficiency leads to increased remains poorly understood. In this study, we report phosphorylates suppresses its enzymatic activity. reduces phosphorylation promotes antiviral responses, thereby...
Abstract This study investigates the causal relationship between investor sentiment and stock returns in USA by conducting a quantile Granger non‐causality test. Employing two proxies for – index developed Baker Wurgler 2007 University of Michigan Consumer Survey, consumer confidence we find that strengthens when tail interval is considered. finding implies could provide incremental predictability under extreme market situation, which cannot be found using traditional causality...
ABSTRACT Epidemiologic studies showed that low birth weight is associated with high cholesterol and an increased risk of cardiovascular diseases in adulthood. This study aimed to elucidate the intrauterine programming mechanisms adult hypercholesterolemia. The results prenatal nicotine exposure (PNE) caused growth retardation hypercholesterolemia male offspring rats. Hepatic synthesis output were deceased utero but adults; hepatic reverse transport (RCT) persistently before after birth....
Platelet-rich plasma (PRP) is a portion of blood enriched with platelets widely investigated for accelerating bone and soft tissue healing.
3-Hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR) catalyzes the formation of mevalonate. In many classes organisms, this is committed step leading to synthesis essential compounds, such as cholesterol. However, a high level cholesterol an important risk factor for coronary heart disease, which effective clinical treatment block HMGR using inhibitors like statins. Recently structures catalytic portion human complexed with six different statins have been determined by delicate...
Pyrrolizidine alkaloids (PAs) are a type of natural phytotoxin that contaminate food and feed become an environmental health risk to humans livestock. PAs exert toxicity requires metabolic activation by cytochrome P450 (CYP) 3A, case reports showed fetuses quite susceptible toxicity. The aim this study was explore the characteristics developmental fetal hepatotoxicity induced retrorsine (RTS, typcial toxic PA) underlying mechanism. Pregnant Wistar rats were intragastrically administered with...
1. Indole-3-carbinol (I3C), a major indole compound found in high levels cruciferous vegetables, shows broad spectrum of biological activities. However, few studies have reported the effect I3C on alcoholic liver injury. In present study, we investigated protective acute ethanol-induced hepatotoxicity and acetaldehyde-stimulated hepatic stellate cells (HSC) activation using precision-cut slices (PCLS). 2. Rat PCLS were incubated with 50 mmol/L ethanol or 350 μmol/L acetaldehyde, different...
1 Liver fibrosis is the compensatory state of cirrhosis. In long asymptomatic period, it imperative to select a proper dosing regimen for drugs that are applicable hepatic fibrosis. Otherwise, progressive deterioration uncompensated cirrhosis may occur. The present study explored characteristics drug metabolism in fibrotic liver. 2 A rat precision-cut liver slice (PCFLS) technique was established and verapamil studied employing this technique. model successfully induced integrating complex...