A5040308300- Pharmaceutical Practices and Patient Outcomes
- Lipid Membrane Structure and Behavior
- Nanoparticle-Based Drug Delivery
- Health Systems, Economic Evaluations, Quality of Life
- Pharmacogenetics and Drug Metabolism
- RNA Interference and Gene Delivery
- Pharmaceutical studies and practices
- Advancements in Transdermal Drug Delivery
- Microfluidic and Capillary Electrophoresis Applications
- Dementia and Cognitive Impairment Research
- Patient-Provider Communication in Healthcare
- Geriatric Care and Nursing Homes
- Proteins in Food Systems
- Patient Safety and Medication Errors
- Drug Transport and Resistance Mechanisms
- Advanced Drug Delivery Systems
- Protein purification and stability
- Biochemical Analysis and Sensing Techniques
- Pregnancy and Medication Impact
- Protein Interaction Studies and Fluorescence Analysis
- Surfactants and Colloidal Systems
- Health Policy Implementation Science
- Child and Adolescent Health
- Asthma and respiratory diseases
- Schizophrenia research and treatment
Bispebjerg Hospital
2018-2025
Copenhagen University Hospital
2018-2025
University of Copenhagen
2004-2025
Capital Region of Denmark
2025
Frederiksberg Hospital
2018-2024
The Capital Region Pharmacy
2023-2024
Leo Pharma (Denmark)
2005-2011
Schools of Visual Arts, The Royal Danish Academy of Fine Arts
1996-2003
Brain capillary endothelial cells (BCECs) express transferrin receptors. The uptake of a potential drug vector (OX26, or anti—transferrin receptor antibody IgG2a) conjugated to polyethyleneglycol-coated liposomes by BCECs was studied using in situ perfusion 18-day-old rats which the OX26 is almost twice as high adult rat. Using radio-labeling, after 15-minute approximately 16 times higher than that nonimmune IgG2a (Ni-IgG2a). and OX26-conjugated selectively distributed BCECs, leaving choroid...
Patients at psychiatric homes are a vulnerable group with several factors complicating their pharmacological treatment. Psychiatric patients in stable treatment transferred from specialist care to primary care, which presents new challenges as general practitioners (GPs) may feel that they not sufficiently trained prescribing and tapering drugs. Medication reviews (MRs) have been seen improve the appropriateness of - especially when performed interdisciplinary teams. Thus, aim this study was...
Abstract In this work, the applicability of using CE to perform a physicochemical characterization PEGylated liposomal drug formulation anti‐cancer agent oxaliplatin was examined. Characterization instrumentation encompassed: determination electrophoretic mobilities, size by Taylor dispersion analysis and interaction studies. Electrophoretic mobilities determined were compared with results obtained laser Doppler electrophoresis, which found be subject larger variation. Average hydrodynamic...
The Global Initiative for Asthma (GINA) has presented a shift in pharmacological asthma treatment. objective of this study was to explore factors influencing successful switch new treatment approach with focus on patients' attitudes toward change and supportive initiatives. This performed as case involving quantitative questionnaire qualitative semi-structured interview. A total 284 responses were collected from the questionnaire, 141 included. results showed that patients thought...
The increasing population of elderly individuals had led to an number polypharmacy patients. Polypharmacy increases the risk adverse drug reactions and hospitalization. One means combat involves performing medication reviews, which can be conducted by different methods stakeholders.The study objective was explore value involving health-care professions in reviews at equal closely integrated collaborative physical meeting for a long-term care facility. A specific focus contributions opinions...
Polyethylene glycol (PEG) modification of liposomes is one the most commonly applied ways increasing both in vitro and vivo stability liposomes. The formed are referred to as stealth because PEG corona renders invisible macrophages bloodstream. first detailed small-angle neutron scattering analysis PEG-modified presented here. An analytical model for derived, where described a water core surrounded by bilayer lipid film with grafted polymer chains Gaussian random coil conformation attached...
Background: The cytochrome P450 drug metabolizing enzymes CYP2D6 and CYP2C19 are the major targets for pharmacogenomics (PGx) testing determining response. Clinical dosing guidelines specific drug-gene interactions (DGI) publicly available through PharmGKB. aim of this register study was to map use drugs in Denmark having actionable (AG) i.e., recommendations different from standard or DGI terms consumption. Methods: Danish Register Medicinal Product Statistics source retrieve consumption...
Background: Clopidogrel and proton pump inhibitors (PPIs) are among the most used drugs in Denmark for which there exists pharmacogenomics (PGx)-based dosing guidelines FDA annotations. In this study, we further scrutinized use of clopidogrel PPIs when prescriptions were redeemed from Danish Pharmacies alone or combination population persons with diabetes Denmark. The focus deals potential applying PGx-guided antiplatelet therapy taking both drug–drug interactions (DDI) drug–gene (DGI) into...
The cytochrome P450 (CYP) enzyme family catalyses the metabolism of approximately 80% all medications.1, 2 Many genes encoding CYP enzymes exhibit high levels polymorphism that affect their expression and activity. most frequent clinically important variations exist within CYP2D6, CYP2C19 CYP2C9.1 extensively studied drug-metabolizing enzyme, has over 100 allelic variants is responsible for metabolizing about 25% marketed 3 CYP2C9 are collectively 20% medications. It estimated 74%–97%...