A5087420849- Estrogen and related hormone effects
- Genetic factors in colorectal cancer
- Retinoids in leukemia and cellular processes
- Reproductive System and Pregnancy
- Immune Cell Function and Interaction
- Molecular Biology Techniques and Applications
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- CAR-T cell therapy research
- Protease and Inhibitor Mechanisms
- Advanced Proteomics Techniques and Applications
- Advanced Biosensing Techniques and Applications
- Sarcoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Photodynamic Therapy Research Studies
- Digestive system and related health
- Antioxidant Activity and Oxidative Stress
- Colorectal Cancer Treatments and Studies
- T-cell and B-cell Immunology
- Cell Image Analysis Techniques
University Cancer Center Hamburg
2021-2024
Universität Hamburg
2021-2024
University Medical Center Hamburg-Eppendorf
2021-2024
University of Lübeck
2007-2015
University of Potsdam
2006-2010
University Hospital Schleswig-Holstein
2010
// Timo Gemoll 1 , Franziska Epping Lisa Heinrich Britta Fritzsche Uwe J. Roblick Silke Szymczak 2 Sonja Hartwig 3 Reinhard Depping 4 Hans-Peter Bruch Christoph Thorns 5 Stefan Lehr Andreas Paech 6,* and Jens K. Habermann 1,* Section for Translational Surgical Oncology Biobanking, Department of Surgery, University Lübeck Medical Center Schleswig-Holstein, Lübeck, Germany Institute Informatics Statistics, Kiel, Clinical Biochemistry Pathobiochemistry, German Diabetes (DZD), Düsseldorf,...
Background: γδ T cells represent a unique cell subpopulation due to their ability recognize cancer in receptor- (TCR) dependent manner, but also non-major histocompatibility complex- (MHC) restricted way via natural killer receptors (NKRs). Endowed with these features, they attractive effectors for immuno-therapeutic strategies better safety profile and more favorable anti-tumor efficacy comparison conventional αβ cells. Also, remarkable progress has been achieved re-activating exhausted...
Aneuploidy is an independent risk factor for forthcoming carcinogenesis in ulcerative colitis (UC). An inferior prognosis of patients with colitis-associated colorectal cancer (UCC) compared those sporadic (SCC) has been reported, but remains controversial. This prompted us to investigate if aneuploidy can be observed UCCs as frequently their counterpart and per se might a driving feature poor UCC.We obtained clinical follow-up 257 SCC (average observation time 57 months) 31 UCC (51 months)....
Abstract Vitamin A deficiency is known to be accompanied with immune and susceptibility a wide range of infectious diseases. Experimental evidence suggests that the active metabolites vitamin mediate its effects on system are retinoic acids (RA), which ligands for nuclear RA receptor (RAR) family. were previously shown both promote proliferation regulate apoptosis thymocytes. In this study we detected age‐dependent mRNA expression retinaldehyde dehydrogenases (RALDH1 2), cellular binding...
The major breakthrough in cancer therapy with immune checkpoint inhibitors (ICIs) has highlighted the important role of checkpoints antitumoral immunity. However, most patients do not achieve durable responses, making biomarker research this setting essential. CD27 is a well known costimulatory molecule, however impact its soluble form ICI poorly investigated. Therefore, we aimed at testing circulating concentrations (sCD27) and bound to extracellular vesicles (EVs) as potential biomarkers...
Abstract The retinoic acid (RA) synthesizing enzymes, retinaldehyde dehydrogenases (RALDH), are expressed in specific spatial and temporal patterns uterine tissues during estrous cycle early pregnancy mice. Expression of RALDH1 2 has been shown to be induced by estrogen treatment within the uterus. In this study, we determined influence progesterone 17‐ß‐estradiol on expression RA‐metabolizing enzyme CYP26A1 after time intervals (1, 4, 24, 48 hr ovariectomized mice). a following experiment,...
Malignant transformation in ulcerative colitis (UC) is associated with pronounced chromosomal instability, reflected by aneuploidy. Although aneuploidy can precede primary cancer diagnosis UC for more than a decade, little known of its cellular consequences. Whole-genome gene expression analysis was applied to noninflamed colon mucosa, mucosal biopsies patients UC, and UC-associated carcinomas (UCCs). DNA image cytometry used stratify samples into ploidy types. Differentially expressed genes...
The active metabolite of vitamin A, retinoic acid (RA), plays an important role in the female reproductive system. synthesis RA is tightly regulated by activity retinaldehyde dehydrogenases (Raldh). Among these, Raldh1 and Raldh2 exhibit specific temporal spatial expression patterns mouse uterus, both during oestrous cycle early pregnancy. In present study, we have assessed whether oestradiol progesterone directly influence uterine ovariectomised mice. We investigated effect gestagen...
Einleitung: Patienten mit Colitis ulcerosa (UC) haben ein erhöhtes Risiko für das Entstehen kolorektaler Karzinome. Trotz Vorsorgekoloskopien werden frühe Läsionen übersehen und Karzinome erst spät detektiert.
A late diagnosis of colorectal cancer leads to a significant reduction average survival time. In current screening programs most the tumours are detected at advanced stages. Therefore, highly sensitive and specific biomarkers must be identified allow malignancy detection very early Colon specimens consist heterogeneous tissue including different cell types such as tumour-, inflammatory- stroma-cells. For better understanding tumourgenesis identify potential high sensitivity specificity, it...