A5043885361- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- vaccines and immunoinformatics approaches
- Influenza Virus Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Diabetes and associated disorders
Australian Regenerative Medicine Institute
2016-2020
Monash University
2016-2020
Peter Doherty Institute
2014-2016
The University of Melbourne
2014-2016
Significance Exactly how memory cells are selected into a recall response to acute viral infection (stochastic or deterministic) remains unresolved. This paper demonstrates definitively that selection of virus-specific CD8 + T from occurs via active particular T-cell clones after secondary virus and this appears be based on the avidity receptor (TCR) for virus-derived peptide (p) major histocompatibility complex class I molecule. We also show despite clear clonal preferences, there is no...
Abstract Virus-specific CTL responses typically fall into reproducible hierarchies with particular epitopes eliciting either immunodominant or subdominant after viral challenge. The recently acquired capacity to directly enumerate naive precursors (CTLps) in both mice and humans has implicated CTLp frequency as a key predictor of immune response magnitude Ag However, recent studies have indicated that frequencies do not necessarily predict the size Ag-driven response, indicating an important...
Viral escape from CD8+ cytotoxic T lymphocyte responses correlates with disease progression and represents a significant challenge for vaccination. Here, we demonstrate that cell recognition of the naturally occurring MHC-I-restricted LCMV-associated immune variant Y4F is restored following vaccination proline-altered peptide ligand (APL). The APL increases MHC/peptide (pMHC) complex stability, rigidifies facilitates receptor (TCR) through reduced entropy costs. Structural analyses pMHC...
Abstract Viral escape from CD8 + cytotoxic T lymphocyte responses correlates with disease progression and represents a significant challenge for vaccination. Here, we demonstrate that cell recognition of the naturally occurring MHC-I-restricted LCMV-associated immune variant Y4F is restored following vaccination proline-altered peptide ligand (APL). The APL increases MHC/peptide (pMHC) complex stability, rigidifies facilitates receptor (TCR) through reduced entropy costs. Structural analyses...