A5047739980- Prostate Cancer Treatment and Research
- Advanced Radiotherapy Techniques
- Radiopharmaceutical Chemistry and Applications
- Lung Cancer Diagnosis and Treatment
- Prostate Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Radiation Therapy and Dosimetry
- Effects of Radiation Exposure
- Cancer, Lipids, and Metabolism
- Medical Imaging Techniques and Applications
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac Imaging and Diagnostics
- Radiation Dose and Imaging
- Colorectal and Anal Carcinomas
- Advanced X-ray and CT Imaging
- Innovations in Medical Education
- Bone health and treatments
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Surgical Treatments
- Head and Neck Cancer Studies
- Estrogen and related hormone effects
- Cancer Immunotherapy and Biomarkers
- Glioma Diagnosis and Treatment
- Surgical site infection prevention
- Lanthanide and Transition Metal Complexes
Queen's University Belfast
2012-2025
Belfast Health and Social Care Trust
2013-2024
University of Ulster
2014-2024
Belfast City Hospital
2014-2024
Queens University
2024
The Northern Ireland Cancer Centre
2013-2023
Churchill Hospital
2023
University of Oxford
2023
Washington University in St. Louis
2022
Najran University
2021
Background and purpose Symptomatic arrhythmia is common following radiotherapy for non-small cell lung cancer (NSCLC), frequently resulting in morbidity hospitalization. Modern treatment planning technology theoretically allows sparing of cardiac substructures. Atrial fibrillation (AF) comprises the majority post-radiotherapy arrhythmias, but efforts to prevent this cardiotoxicity have been limited as causative substructure not known. In study we investigated if incidental radiation dose...
Cardiac disease is a dose-limiting toxicity in non-small cell lung cancer radiotherapy. The dose to the heart base has been associated with poor survival multiple institutional and clinical trial datasets using unsupervised, voxel-based analysis. Validation not undertaken cohort individual patient delineations of cardiac or for endpoint events. purpose this study was assess association radiation overall risk events contours.
Radiation-induced cardiotoxicity poses a significant challenge in lung cancer management because of the close anatomical proximity heart to lungs, compounded by high prevalence cardiovascular risk factors among patients.
Emerging data suggest that dose-sparing several key cardiac regions is prognostically beneficial in lung cancer radiotherapy. The substructures are challenging to contour due their complex geometry, poor soft tissue definition on computed tomography (CT) and cardiorespiratory motion artefact. A neural network was previously trained generate the using three-dimensional radiotherapy planning CT scans (3D-CT). In this study, performance of tool average intensity projection from four-dimensional...
Radiation cardiotoxicity is a dose-limiting toxicity and major survivorship issue for patients with non-small cell lung cancer (NSCLC) completing curative-intent radiotherapy, however patients' cardiovascular baseline not routinely optimised prior to treatment. In this study we examined the impact of statin therapy on overall survival post-radiotherapy cardiac events.Patients treated between 2015-2020 at regional center were identified. Clinical notes interrogated patient, tumor details,...
Introduction Ensuring equivalence in high-stakes performance exams is important for patient safety and candidate fairness. We compared inter-school examiner differences within a shared OSCE resulting impact on students' pass/fail categorisation.
Flattening filter free (FFF) linear accelerators allow for an increase in instantaneous dose-rate of the x-ray pulses by a factor 2–6 over conventional flattened output. As result, radiobiological investigations are being carried out to determine effect these higher dose-rates on cell response. The studies reported thus far have presented conflicting results, highlighting need further investigation. To impact increased from FFF exposures Varian Truebeam medical accelerator was used irradiate...
The relative biological effectiveness of cobalt-60 gamma rays (1.17, 1.33 Mev) and 22-Mevp x from a betatron with reference 200-kvp (primary HVL 1.4 mm Cu) has been determined by using the slope survival curve yeast Saccharomyces cerevisiae (based on macrocolony counts) as end point. average RBE five experiments was found to be 0.85 for radiation O.85 radiation, uncertainties order J-57 engin 0.05 in each case. No significant difference between demonstrated. (auth)
Introduction Whilst rarely researched, the authenticity with which Objective Structured Clinical Exams (OSCEs) simulate practice is arguably critical to making valid judgements about candidates' preparedness progress in their training. We studied how and why an OSCE gave rise different experiences of for participants under circumstances.
The optimal methodology for defining response with <sup>18</sup>F-FDG PET after curative-intent chemoradiation non–small cell lung cancer (NSCLC) is unknown. We compared survival outcomes according to the criteria of European Organization Research and Treatment Cancer (EORTC), PERCIST 1.0, Peter Mac metabolic visual criteria, Deauville respectively. <b>Methods:</b> Three prospective trials NSCLC, involving baseline posttreatment PET/CT imaging, were conducted between 2004 2016. Responses...
Results of previous studies investigating the association between GCA and malignancy are conflicting. We performed a study risk cancer in patients with biopsy-proven GCA.Patients were identified from pathology reports temporal artery biopsies major laboratories South Australia (SA). All subjects linked to SA Cancer Registry identify cases until 31 December 2006. Standardized incidence ratios (SIRs) for determined using age- gender-specific rates SA.There 226 (163 females 63 males)....
Many clinical studies and epidemiological investigations have clearly demonstrated that women are twice as likely to develop cholesterol gallstones men, oral contraceptives other estrogen therapies dramatically increase risk. Further, animal revealed promotes gallstone formation through the receptor (ER) α, but not ERβ, pathway. More importantly, some genetic pathophysiological found G protein-coupled (GPER) 1 is a new gene,