A5033988320- Bone Tissue Engineering Materials
- Advanced Nanomaterials in Catalysis
- Graphene and Nanomaterials Applications
- Calcium Carbonate Crystallization and Inhibition
- Laser Applications in Dentistry and Medicine
- biodegradable polymer synthesis and properties
- Dental materials and restorations
- Nanoparticles: synthesis and applications
- Silk-based biomaterials and applications
- Electrospun Nanofibers in Biomedical Applications
- Bone Metabolism and Diseases
- Protein Hydrolysis and Bioactive Peptides
- Bone and Dental Protein Studies
- Facial Trauma and Fracture Management
- Analytical Chemistry and Sensors
- Nanocluster Synthesis and Applications
- Titanium Alloys Microstructure and Properties
- Diatoms and Algae Research
- Endodontics and Root Canal Treatments
- Layered Double Hydroxides Synthesis and Applications
- Microfluidic and Capillary Electrophoresis Applications
- Cancer Cells and Metastasis
- Mesenchymal stem cell research
- Membrane Separation Technologies
- 3D Printing in Biomedical Research
University of Leeds
2017-2024
ORCID
2020
Aging and age-related changes impact the quality of life (QOL) in elderly with a decline movement, cognitive abilities increased vulnerability towards diseases (ARDs). One key contributing factors is cellular senescence, which triggered majorly by DNA damage response (DDR). Accumulated senescent cells (SCs) release senescence-associated secretory phenotype (SASP), includes pro-inflammatory cytokines, matrix metalloproteinases (MMPs), lipids chemokines that are detrimental to surrounding...
Bone damage arising from fractures or trauma frequently results in infection, impeding the healing process and leading to complications. To overcome this challenge, we engineered highly porous chitosan scaffolds (S1, S2, S3) by incorporating 30 (wt)% iron-doped dicalcium phosphate dihydrate (Fe-DCPD) minerals different concentrations of cerium oxide nanoparticles (CeO2) (10 (wt)%, 20 (wt)%) using lyophilisation technique. The were specifically designed for controlled release antibacterial...
Dicalcium Phosphate Dihydrate (DCPD) mineral scaffolds alone do not possess the mechanical flexibility, ease of physicochemical properties' tuneability or suitable porosity required for regenerative bone scaffolds. Herein, we fabricated highly porous freeze-dried chitosan embedded with different concentrations minerals, i.e., 0, 20, 30, 40 and 50 (wt)%. Increasing DCPD concentration led to increased scaffold crystallinity, where % crystallinity CH, 40, 50-DCPD was determined be 0.1, 20.6,...
Challenges to the musculoskeletal system negatively impact quality of life people suffering from them, leading pain, a decline in mobility, genetic alterations, and potential disorders. The bone marrow (BM) forms an integral part responsible for erythropoiesis optimal survival various immune stem cells within BM. However, due its dynamic complex three-dimensional (3D) structure, replicating BM physiologically traditional two-dimensional (2D) cell culture settings is often challenging, giving...
Bone healing is a complex process, and if not managed successfully, it can lead to non-union, metal-work failure, bacterial infections, physical psychological patient impairment. Due the growing urgency minimise antibiotic dependency, alternative treatment strategies, including use of nanoparticles, have attracted significant attention. In present study, cerium oxide nanoparticles (Ce
Bone void-filling cements are one of the preferred materials for managing irregular bone voids, particularly in geriatric population who undergo many orthopedic surgeries. However, marrow mesenchymal stem/stromal cells (BM-MSCs) older-age donors often exhibit reduced osteogenic capacity. Hence, it is crucial to evaluate candidate substitute with BM-MSCs from determine true potential, thus simulating clinical situation. With this concept, we investigated potential shell nacre cement (SNC), a...
Biodegradable scaffolds are needed to repair bone defects. To promote the resorption of scaffolds, a large surface area is required encourage neo-osteogenesis. Herein, we describe synthesis and freeze-drying methodologies ferric-ion (Fe3+) doped Dicalcium Phosphate Dihydrate mineral (DCPD), also known as brushite, which has been favour in situ condition for osteogenesis. In this investigation, role chitosan during DCPD was explored enhance antimicrobial, scaffold pore distribution,...
Bone regeneration and repair are complex processes with the potential of added complications, like delayed repair, fracture non-union, post-surgical infections. These conditions remain a challenge globally, pressurizing economy patients suffering from these conditions. Applications nanotechnology (NBT) in field medicine have provided medium for several approaches to support global challenges. Tissue engineering is one such that has been on rise last three decades through utilization NBT...
Chitosan (CS), a biopolymer, holds significant potential in bone regeneration due to its biocompatibility and biodegradability attributes. While crustacean-derived CS is conventionally used research, there growing interest fungal-derived for equally potent properties regenerative applications. Here, we investigated the physicochemical biological characteristics of fungal (MDC) crustacean (ADC)-derived scaffolds embedded with different concentrations tricalcium phosphate minerals (TCP), i.e.,...
The emergence of ultrashort pulsed near-IR lasers has opened novel opportunities not only for investigating the physics interaction such with photo-active biomaterials reconstructive and restorative bone dental tissue engineering, but also analysing light-matter in CW laser regime surgical applications.The clinically-relevant examples discussed are enamel restoration, osteoporotic bone-mass augmentation, reconstructing damaged after trauma.Here, we explain process energy absorption both...
Osteochondral tissue damage is a serious concern, with even minor cartilage dramatically increasing an individual's risk of osteoarthritis. Therefore, there need for early intervention osteochondral regeneration. 3D printing exciting method developing novel scaffolds, especially creating biological scaffolds engineering. However, many techniques rely on lattice structure, which often demonstrates poor cell bridging between filaments due to its large pore size, reducing regenerative speed and...
Angiogenesis is a vital requirement for the formation of healthy tissue and bone; this currently one greatest challenges in field engineering. A promising strategy to achieve suitable, intrinsic vasculature use biodegradable microfluidic networks [1]. Pre-seeding medical devices with angiogenic growth factors, stem cells, collagen, specific proteins bone cells will allow successful soft regeneration. Biodegradable scaffolds may be constructed by numbering up operation where several layers...
Clinical Need: Ageing and lifestyle are two commonly known factors that determine the health of dental enamel. Consumption acidic food beverages with low pH (<5), stomach acid reflux, underlying condition aggressive brushing adversely affect longevity enamel mineral. Acid erosion is a common in global population, if not treated, may lead to compromised dietary intake, which compromise long-term health. Anatomically, an acellular-avascular tissue, containing more than 95% hydroxyapatite...
An IR femtosecond pulsed laser was used for micropatterning of biomineral containing chitosan membranes, aiming to enhance bone mineralization and angiogenesis. Pre post irradiation materials have been characterized with XRD, SEM spectroscopic techniques.
Abstract Bone healing is a complex process, and if not managed, can lead to bacterial infections, non-union compromised of bone. The broad overuse antibiotics has led the emergence antibiotic-resistant bacteria. Due growing urgency minimise dependency on antibiotic drugs, alternative treatment strategies, including use nanoparticles, have attracted significant attention. Bivalent cerium oxide nanoparticles (Ce 4+ Ce 3+ ) synthesised via hydroxide mediated approach were calcined at 280, 385...