A5063718730- Asthma and respiratory diseases
- Sinusitis and nasal conditions
- Allergic Rhinitis and Sensitization
- Nanoparticle-Based Drug Delivery
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- Phytochemical compounds biological activities
- Hereditary Neurological Disorders
- Chronic Myeloid Leukemia Treatments
- Cholinesterase and Neurodegenerative Diseases
- Ubiquitin and proteasome pathways
- Nuclear Receptors and Signaling
- Cancer therapeutics and mechanisms
- Estrogen and related hormone effects
- Neurogenesis and neuroplasticity mechanisms
- Insect Pest Control Strategies
- Pain Mechanisms and Treatments
- Curcumin's Biomedical Applications
- Pluripotent Stem Cells Research
- Fibroblast Growth Factor Research
- Chemical synthesis and alkaloids
- Alkaloids: synthesis and pharmacology
- Barrier Structure and Function Studies
- PI3K/AKT/mTOR signaling in cancer
- Traditional and Medicinal Uses of Annonaceae
Nanjing University of Chinese Medicine
2025
University of South China
2025
General Hospital of Shenyang Military Region
2012-2023
Chinese People's Liberation Army
2023
Jinzhou Medical University
2021
Huazhong University of Science and Technology
2014-2018
Tongji Hospital
2014-2018
Shenyang 242 Hospital
2013
The expression of chronic rhinosinusitis (CRS) is multidimensional. Disease heterogeneity in patients with CRS remains poorly understood. This study aimed to identify endotypes using cluster analysis by integrating multidimensional characteristics and explore their association treatment outcomes.
Eosinophilic and non-eosinophilic chronic rhinosinusitis with nasal polyps (CRSwNP) display distinct patterns of inflammation. However, the pathogenic mechanisms underlying heterogeneity CRSwNP need further investigation.To investigate local immunoglobulin E (IgE) production phenotype mast cells in eosinophilic Chinese.Total specific IgE levels were analysed by means ImmunoCAP system. The molecular steps involved class-switch recombination to investigated using RT-PCR assays. Mast cell...
In vivo stability and consequent high tumor accumulation is highly desired for nonviral gene therapy.Here, a well-defined cationic nanogel system (NPS) was facilely prepared gastric therapy.The physical chemical properties of NPS were finely regulated investigated. vitro transfer efficiency obviously promoted due to stable polyplex structure, small size, narrow size distribution weak surface potential. Interestingly, the transfection further enhanced by its passive targeting function....
Brigatinib is approved in multiple countries for the treatment of patients with anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC). Despite its superior efficacy, dermal toxicities caused by brigatinib cannot be overlooked. However, underlying mechanism remains unknown. The effects on proliferation ability human immortalized keratinocyte (HaCaT) cells were evaluated using Cell Counting Kit-8 (CCK-8) proliferation, colony formation, and 5-ethynyl-2'-deoxyuridine...
It is well known that estrogen receptor α (ERα) participates in the pathogenic progress of breast cancer, hepatocellular carcinoma and head neck squamous cell carcinoma. In neuroblastoma cells related cancer clinical specimens, moreover, ectopic expression ERα has been identified. However, detailed function proliferation yet unclear.The transcriptional activity ETS-1 (E26 transformation specific sequence 1) was measured by luciferase analysis. Western blot assays Real-time RT-PCR were used...
The 80% ethanol extract of Alstonia yunnanensis afforded five new monoterpenoid indole alkaloids: 11-hydroxy-6,7-epoxy-8-oxo-vincadifformine (1), 14-chloro-15-hydroxy- vincadifformine (2), perakine N(4)-oxide (3), raucaffrinoline (4), and vinorine N(1),N(4)-dioxide (5), together with three known compounds: 11-methoxy-6,7-epoxy-8-oxo- (6), (7) (8). structures the isolated compounds were established based on 1D 2D (1H-1H-COSY, HMQC, HMBC, ROESY) NMR spectroscopy, in addition to high resolution...
Clinically, surgery assisted by chemotherapy is the most effective treatment of cancer. But from our clinical observation, median survival patients with glioblastoma still not so good only 15-16 months. The low therapeutic index mainly due to blood-brain barrier (BBB) which significantly hindered chemotherapeutic drug accumulation in tumor tissue. One main composition BBB astrocyte, contains a lipophilic cell membrane, prevents more than 98% small-molecule drugs entering brain. Previously,...
β-elemene, a plant-derived drug extracted from Curcuma wenyujin, has demonstrated marked antiproliferative effects on glioblastoma, while toxicity remains low. However, the underlying molecular mechanisms of antitumor activity β-elemene remain to be elucidated. Previously, it was identified that glia maturation factor β (GMFβ)/mitogen-activated protein kinase (MAPK) 3/6/p38 pathway participates in glioblastoma. In present study, order illustrate association GMFβ and extracellular...
Neuropathic pain takes a heavy toll on individual well-being, while current therapy is far from desirable. Herein, we assessed the analgesic effect of β-elemene, chief component in traditional Chinese medicine Curcuma wenyujin, and explored underlying mechanisms at level spinal dorsal horn (SDH) under neuropathic pain. A spared nerve injury (SNI)-induced model was established rats. Intraperitoneal injection (i.p.) β-elemene administered for 21 consecutive days. Mechanical allodynia by von...
Purpose: As a kind of difficult to cure tumour, malignant gliomas have attracted widespread attention. The proliferation and immune escape tumour cells were closely related the development gliomas. aim this study was investigate role endothelin B receptor (NTBR) in gliomas.Methods: RT-PCR used detect expression NTBR mRNA glioma tissue cell lines. tissues detected by immunohistochemistry. MTT assay viability U87 after adding NTBR. Cell cloning ability. Western blot TGF-β Treg U87.Result:...
Factor binding IST-1 (FBI-1) plays an important role in oncogenic transformation and tumorigenesis. As FBI-1 is over-expressed multiple human cancers, the regulation of itself would provide new effective options for cancer intervention. In this work, we aimed to study that EPAS-1 regulating FBI-1. We use fact specificity protein-1 (SP-1) one crucial transcription factors FBI-1, SP-1 can interact with endothelial pas domain (EPAS-1) induction hypoxia related genes. The showed indispensible...
Department of Neurosurgery, General Hospital the Northern Theater Command Chinese People's Liberation Army, Shenyang, Liaoning Province, China (Cao P, Li J, Liang G) Key Laboratory Precision Medical Research on Major Chronic Disease, Shengjing University, (Liu Z) Correspondence to: Peng Cao, MD, [email protected]. Received June 20, 2023 in revised form July 05, Accepted 10, This is an open-access article distributed under terms Creative Commons Attribution-Noncommercial-Share Alike 4.0...