Narcolepsy is a sleep disorder caused by deficiency of orexin signaling. However, the neural mechanisms which deficient signaling causes abnormal rapid eye movement (REM) characteristics narcolepsy, such as cataplexy and frequent transitions to REM states, are not fully understood. Here, we determined activity dynamics neurons during that suppress architecture narcolepsy. Orexin were highly active wakefulness, showed intermittent synchronous non-REM (NREM) sleep, quiescent prior transition...

This study aimed to examine the effect of applying BFR during rest periods repeated cycling sprints on muscle oxygenation.Seven active males performed 5 × 10-s maximal pedaling efforts with 40-s passive rest, or without application period. was applied for 30 s between (between and 35 into rest) through a pneumatic pressure cuff inflated at 140 mmHg. Vastus lateralis oxygenation monitored using near-infrared spectroscopy. In addition, blood lactate concentration heart rate were also...

Guillain-Barré syndrome (GBS), Miller Fisher (MFS) and Bickerstaff brainstem encephalitis (BBE) are a group of autoimmune neurological disorders (GBS spectrum disorder) that rarely recur. Recently, anti-ganglioside complex antibodies (GSC-Abs) were identified in patients with GBS disorder. However, there has been no case report describing GSC-Abs profiles recurrent showing different phenotypes. We the 33-year-old male patient GQ1b-seronegative BBE-GBS after two prior episodes MFS-GBS. Our...

Abstract Background Various wearable devices for objectively evaluating motor symptoms of patients with Parkinson’s disease (PD) have been developed. Importantly, previous studies suggested protective effects physical activity in PD. However, the relationships between conventional clinical ratings PD and three-axis accelerometer measures (e.g., daily levels [PAL] or metabolic equivalents task [METs]) are still unclear, particularly METs. In current study, we sought to elucidate these on a...

Moyamoya vasculopathy (MMV) associated with Graves' disease (GD) is a rare condition resulting in ischemic stroke accompanied by thyrotoxicity. Radiological findings of vasculitis have been reported the walls distal internal carotid arteries (ICAs) these patients; however, no reports described detail processes progression lesions proximal ICA. Moreover, treatments to prevent recurrence and MMV not yet sufficiently elucidated. We report progressive case GD review literature clarify...

To investigate the carbohydrate metabolism, acid-base balance, and potassium kinetics in response to exercise moderate hypoxia among endurance athletes.Nine trained athletes [maximal oxygen uptake (VO2max): 62.5 ± 1.2 mL/kg/min] completed two different trials on days: either [fraction of inspired (FiO2) = 14.5%, HYPO] or normoxia (FiO2 20.9%, NOR). They performed a high-intensity interval-type consisting 10 × 3 min runs at 90% VO2max with 60 s running (active rest) 50% between sets (HYPO)...

Purpose We explored the effect of heat stress during an acute endurance exercise session in hypoxia on erythropoietin (EPO) response. Methods A total 12 healthy males cycled at a constant workload (60% power output associated with their maximal oxygen uptake under each respective condition) for 60 min three different environments: hot and (H+H; fraction inspiratory or FiO2: 14.5%, 32℃), (HYP; 23℃), normoxia (NOR; 20.9%, 23℃). After completing exercise, participants remained chamber 3 h to...

The use of buccal mucosa and a tongue flap in reconstruction full-thickness defects the lower lip is described. patient’s face received heavy blow traffic accident. Necrosis caused by hematogenous disturbance occurred more than half entire vermilion. patient underwent two-stage operation for lip. First, vestibuloplasty was performed using mucosal flap. Subsequently, vermilion surgically reconstructed from tip tongue. This operative method less risky because its favorable prognosis. An...

A case of orbital abscess with gas gangrene due to odontogenic infection is reported. Although abscesses are rare, they may result in fatal complications. 68-year-old woman presented pain and swelling the left cheek lower eyelid. She was unable open her eye. Oral examination revealed alveolar gingival a periapical lesion upper anterior tooth. Computed tomographic scans confirmed formation orbit presence bubble. The ocular tension 50 mmHg. On admission our hospital, patient started receive...

扁平苔癬 (Oral lichen planus,以下OLP) の臨床型分類は,2型に分類するものから,3型,6型の分類あるいはさらに細かく分けるものなどさまざまである。典型例では問題はないと考えられるが,病変のタイプが混在している場合にはその判断が診断医によってばらつく可能性が高い。今後OLPの研究を進めるにあたり,各診断医間で再現性のある臨床型分類を検討した。自治医科大学附属病院歯科口腔外科にてOLPと診断された初診時の病態写真を用いて,日本口腔外科学会専門医5名が各々の臨床型分類を行った。結果としてAxéllの2型分類では診断の一致率が高く,分類数が増えるにつれ一致率は低下した。また,診断は網状型の典型例で一致しやすく,病態が混在する症例では相違が見られた。再現性の高さからは2型分類が適切と考えられ,また今後複合型・多発部位発症型の分類の基準を明確に定義づけすることが必要と考えられる。

Herpetic infection is a common disease but the symptoms are often severe in immunocompromised patients.Case 1: A 54-year-old female complained of purpura and contact pain on palatal gingiva after chemotherapy for relapse acute myeloid leukemia. The lesion had rapidly enlarged within few days. Our clinical diagnosis was candidiasis, histopathological HSV infection.Case 2: 47-year-old male visited our clinic with multiple erosion, white plaque mucosal bleeding his lip, tongue buccal mucosa BMT...

We present the case of a 60-year-old female patient who had been treated for angioimmunoblastic T-cell lymphoma (AITL) at hematology department our hospital. The suffering from tenderness on right margin tongue since one month before, which she was referred to department. Histopathological examination performed pathologically revealed presence cytomegalovirus antigen positive cells, which, along with clinical findings, led diagnosis stomatitis caused by cytomegalovirus. Because lesion showed...

A 55-year-old male with myelodysplastic syndrome had been treated at the Hematology Department our hospital. Swelling of left cheek developed in patient, which led to his referral department. Since blisters and distinct dark red plaques were noted on right forearm as well lower limbs, a dermatological examination was requested. Biopsy skin rash performed; biopsy result clinical course diagnosis phlegmon associated Sweet's disease. We provided treatment for infection The patient received...

IgG4-related disease is a recently proposed pathological entity characterized by tumor-like enlargement of one or more organs, IgG4 positive plasma cell accumulation and raised serum levels. We present case submandibular lymphadenopathy with disease. The patient was 49-year-old man, who had been receiving periodontal treatment in our department. investigated swelling the right region that identified previously. An excisional biopsy revealed enlarged lymph nodes. cells were found...

PURPOSE: The purpose of the present study was to deter determine impact reduced carbohydrate (CHO) intake after sprint exercise on breath acetone levels during post-exercise. METHODS: Nine subjects (20.8 ± 0.2 yrs, 170.1 1.6 cm, 65.1 1.8 kg) conducted two trials, consisting lower CHO trial (LOW) or normal (NOR). In each trial, came laboratory at 7:30 evaluate level, blood variables and resting metabolic rate. From 17:00, they started repeated (4 × 30 s maximal cycle exercise). After...