A5034309025- Neuropeptides and Animal Physiology
- Mitochondrial Function and Pathology
- Cancer, Stress, Anesthesia, and Immune Response
- Spaceflight effects on biology
- Immune Cell Function and Interaction
- Radiation Therapy and Dosimetry
Cornell University
2025
Case Western Reserve University
2020
Spaceflight imposes unique stressors that disrupt mitochondrial function, vital for energy production and immune regulation. Our multi-omics analysis (proteomics, bisulfite sequencing, RNA-seq, single-nuclei RNA/ATAC-seq) on astronauts, rodents, model organisms (flies, worms, plants) revealed progressive impairment of oxidative phosphorylation (OXPHOS) during spaceflight, with delayed recovery post-return across species. In radiation ≥10.34 mGy activated persistent stress pathways multiple...
Abstract Opioid peptides are released at sites of injury; their cognate G-protein coupled opioid receptors (OR) expressed on immune cells. Conflicting reports attribute immunostimulatory and immunosuppressive activity to opioids. From a cohort methadone patients controls, we found that chronic use disrupts CD8+ T cell subset balance, via decreased Effector Memory RA+ Exposure cells ex vivo μ-OR or δ-OR agonist differentially regulates thousands protein coding genes. Gene set enrichment...