Rebekah Sanchez‐Hodge
A5065981529- Mitochondrial Function and Pathology
- Spaceflight effects on biology
- Genetic Neurodegenerative Diseases
- Cancer, Lipids, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Ubiquitin and proteasome pathways
- Heat shock proteins research
- DNA Repair Mechanisms
- Ion Transport and Channel Regulation
- Estrogen and related hormone effects
- Renal and related cancers
- Prostate Cancer Treatment and Research
- Chronic Lymphocytic Leukemia Research
- Osteoarthritis Treatment and Mechanisms
- Climate Change and Health Impacts
- Adipose Tissue and Metabolism
- Electrolyte and hormonal disorders
- Insurance, Mortality, Demography, Risk Management
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer Immunotherapy and Biomarkers
- Space Science and Extraterrestrial Life
- Dialysis and Renal Disease Management
- Periodontal Regeneration and Treatments
- Radiation Therapy and Dosimetry
- Neuroethics, Human Enhancement, Biomedical Innovations
University of North Carolina at Chapel Hill
2017-2025
The Ohio State University
2013-2020
Ohio University
2019
Abstract Missions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as kidney largely unexplored. We performed biomolecular (epigenomic, transcriptomic, proteomic, epiproteomic, metabolomic, metagenomic), clinical chemistry (electrolytes, endocrinology, biochemistry) morphometry (histology, 3D imaging, miRNA-ISH, tissue weights) analyses using...
The cytokine IFNγ differentially impacts on tumors upon immune checkpoint blockade (ICB). Despite our understanding of downstream signaling events, less is known about regulation its receptor (IFNγ-R1). With an unbiased genome-wide CRISPR/Cas9 screen for critical regulators IFNγ-R1 cell surface abundance, we identify STUB1 as E3 ubiquitin ligase in complex with signal-relaying kinase JAK1. mediates ubiquitination-dependent proteasomal degradation IFNγ-R1/JAK1 through
The importance of the kidney distal convoluted tubule (DCT) and cortical collecting duct (CCD) is highlighted by various water electrolyte disorders that arise when unique transport properties these segments are disturbed. Despite this critical role, little known about which proteins have a regulatory role in cells how can be regulated individual physiologic stimuli. By combining proteomics, bioinformatics, cell biology approaches, we found E3 ubiquitin ligase CHIP highly expressed...
Spaceflight imposes unique stressors that disrupt mitochondrial function, vital for energy production and immune regulation. Our multi-omics analysis (proteomics, bisulfite sequencing, RNA-seq, single-nuclei RNA/ATAC-seq) on astronauts, rodents, model organisms (flies, worms, plants) revealed progressive impairment of oxidative phosphorylation (OXPHOS) during spaceflight, with delayed recovery post-return across species. In radiation ≥10.34 mGy activated persistent stress pathways multiple...
Proteotoxicity from insufficient clearance of misfolded/damaged proteins underlies many diseases. Carboxyl terminus Hsc70-interacting protein (CHIP) is an important regulator proteostasis in cells, having E3-ligase and chaperone functions often directing damaged towards proteasome recycling. While enhancing CHIP functionality has broad therapeutic potential, prior efforts have all relied on genetic upregulation. Here we report that CHIP-mediated turnover markedly post-translationally...
CHIP (carboxyl terminus of heat shock 70-interacting protein) has long been recognized as an active member the cellular protein quality control system given ability to function both a co-chaperone and ubiquitin ligase. We discovered genetic disease, now known spinocerebellar autosomal recessive 16 (SCAR16), resulting from coding mutation that caused loss ligase function. The initial describing SCAR16 was missense in domain (p.T246M). Using multiple biophysical approaches, we demonstrated...
Monogenetic disorders that cause cerebellar ataxia are characterized by defects in gait and atrophy of the cerebellum; however, patients often suffer from a spectrum disease, complicating treatment options. Spinocerebellar autosomal recessive 16 (SCAR16) is caused coding mutations STUB1, gene encodes multifunctional enzyme CHIP (C terminus HSC70-interacting protein). The disease SCAR16 includes varying age onset, cognitive dysfunction, increased tendon reflex, hypogonadism. Although span...
Objective-To determine the efficiency of a novel point-of-care gravitational marrow separator and bone aspiration needle for concentrated production marrow-derived mesenchymal stem cell (MSC) separation assess effect repeated collections in horses. Animals-8 healthy adult Procedures-Bone was performed twice (1 month apart) from sternebral bodies with standard or prototype multidirectional needle. Concentrated obtained by evaluated WBC platelet counts, automated cytomorphologic differential...
The importance of the kidney distal convoluted tubule (DCT) and cortical collecting duct (CCD) are highlighted by various water electrolyte disorders that arise when unique transport properties these segments disturbed. Despite this critical role, little is known about which proteins play a regulatory role in cells how can be regulated individual physiological stimuli. By combining proteomics, bioinformatics, cell biology approaches alongside gene targeted animal models, we found an...
Androgen Receptor (AR) signaling is a critical driver of hormone-dependent prostate cancer and has also been proposed to have biological activity in female cancers, including type I endometrial carcinoma (EMC). In this study, we evaluated the preclinical efficacy third-generation AR antagonist, enzalutamide, genetic mouse model EMC, Sprr2f-Cre;Ptenfl/fl. model, ablation Pten uterine epithelium leads localized distant malignant disease as observed human EMC. We hypothesized that administering...
Heat shock proteins (HSPs) are a family of molecular chaperones that regulate essential protein refolding and triage decisions to maintaining homeostasis. Numerous co-chaperone directly interact modify the function HSPs, these interactions impact outcome triage, impacting everything from structural cell signaling mediators. The chaperone/co-chaperone machinery protects against various stressors ensuring cellular in face stress. However, coding mutations, expression changes,...
Atherosclerosis is a persistent inflammatory disease characterized by the buildup of lipid-laden macrophages (foam cells) in arterial walls and has been linked to several cardiovascular ailments. Despite advances understanding its pathogenesis, underlying mechanisms atherogenesis, particularly regarding chemokine influence, yet be investigated. Our laboratory previously identified CXCL5, known for involvement responses, as potential mediator atherosclerosis. We found that patients with...
<title>Abstract</title> Missions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as kidney largely unexplored. We performed biomolecular (epigenomic, transcriptomic, proteomic, epiproteomic, metabolomic, metagenomic), clinical chemistry (electrolytes, endocrinology, biochemistry) morphometry (histology, 3D imaging, miRNA-ISH, tissue weights)...
Abstract CHIP (carboxyl terminus of heat shock 70-interacting protein) has long been recognized as an active member the cellular protein quality control system given ability to function both a co-chaperone and ubiquitin ligase. Mutations in are driver spinocerebellar autosomal recessive 16 (SCAR16), or cerebellar CHIPopathy, we initially discovered this disease was caused by loss ligase function. The initial mutation describing SCAR16 missense domain (p.T246M). Using multiple biophysical...
Abstract Androgen Receptor (AR) signaling is a critical driver of hormone-dependent prostate cancer and has also been proposed to have biological activity in female cancers, including type I endometrial carcinoma (EMC). In this study, we evaluated the preclinical efficacy third-generation AR antagonist, enzalutamide, genetic mouse model EMC, Sprr2f-Cre;Pten fl/fl . model, ablation Pten uterine epithelium leads localized distant malignant disease as observed human EMC. We hypothesized that...
Monogenetic disorders that cause cerebellar ataxia are characterized by defects in gait and atrophy of the cerebellum; however, patients often suffer from a spectrum disease, complicating treatment options. Spinocerebellar autosomal recessive 16 (SCAR16) is caused coding mutations STUB1 , gene encodes multi-functional enzyme CHIP (C-terminus HSC70-interacting protein). The disease found SCAR16 includes wide range age onset, cognitive dysfunction, increased tendon reflex, hypogonadism....
One out of every four deaths in the United States can be attributed to heart disease. Atherosclerosis is a prevalent form cardiovascular disease that describes narrowing arteries, leading restriction blood flow. caused part by accumulation lipid‐laden macrophages (foam cells) walls arteries. Determining mechanisms influence lipid metabolism may uncover new approaches modify process and decrease burden. Recently, our lab identified genetic link between expression chemokine CXCL5...