A5091277575- Natural product bioactivities and synthesis
- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Macrophage Migration Inhibitory Factor
- Antioxidant Activity and Oxidative Stress
- Nuclear Receptors and Signaling
- Bioactive Compounds and Antitumor Agents
- Cancer, Hypoxia, and Metabolism
- Genomics, phytochemicals, and oxidative stress
- Bee Products Chemical Analysis
- Immune Response and Inflammation
- Galectins and Cancer Biology
- Dermatology and Skin Diseases
- Pharmacological Effects of Natural Compounds
- Obesity, Physical Activity, Diet
- Retinoids in leukemia and cellular processes
- Natural Compounds in Disease Treatment
- Autophagy in Disease and Therapy
- Ginkgo biloba and Cashew Applications
- Physical Activity and Health
- Cardiovascular and exercise physiology
- Biochemical Analysis and Sensing Techniques
- Spaceflight effects on biology
- Ginger and Zingiberaceae research
- Advanced Chemical Sensor Technologies
Otsuka (Japan)
2013-2025
Otsuka Pharmaceutical (Spain)
2025
Tokyo Metropolitan Institute of Gerontology
2008-2009
Kyoto University
2005-2008
Kyushu Institute of Technology
2003
Parkinson's disease (PD) is a neurodegenerative disorder characterized by selective loss of dopaminergic neurons in the substantia nigra pars compacta. Although understanding pathogenesis PD remains incomplete, increasing evidence from human and animal studies has suggested that oxidative stress an important mediator its pathogenesis. Astaxanthin (Asx), potent antioxidant, been thought to provide health benefits decreasing risk stress-related diseases. This study examined protective effects...
Kaempferol (KMP) is an important flavonoid in many fruits and vegetables. Preclinical studies on KMP have reported its pharmacological effects, including antimicrobial, antioxidant, anti-inflammatory, antitumor, antidiabetic, myocardial protective, neuroprotective effects. Additionally, some epidemiological revealed a negative association between the consumption of KMP-containing foods risk developing several disorders, such as cancer cardiovascular diseases. Thus, although large body...
Spaceflight imposes unique stressors that disrupt mitochondrial function, vital for energy production and immune regulation. Our multi-omics analysis (proteomics, bisulfite sequencing, RNA-seq, single-nuclei RNA/ATAC-seq) on astronauts, rodents, model organisms (flies, worms, plants) revealed progressive impairment of oxidative phosphorylation (OXPHOS) during spaceflight, with delayed recovery post-return across species. In radiation ≥10.34 mGy activated persistent stress pathways multiple...
Abstract IL-1β has been shown to play a pivotal role in the development of inflammatory disorders. We recently found that natural triterpene, ursolic acid (UA), enhanced MIF release from nonstimulated macrophages. In this study, we examined effects UA on production several cytokines resident murine peritoneal macrophages (pMφ). increased protein IL-1β, IL-6, and MIF, but not TNF-α, dose- time-dependent manners. This triterpene also strikingly induced activation p38 MAPK ERK1/2 together with...
Kaempferol (KMP) has numerous important biological functions, and we recently showed that it remarkably increased intracellular adenosine triphosphate (ATP) content in C2C12 myotubes under hypoxic conditions. Since ATP is generated by aerobic energy metabolism or anaerobic glycolysis, hypoxia inducible factor-1α (HIF-1α) been shown to be associated with metabolic remodeling causes shift from glycolysis response Here, investigate the effects of KMP conditions on stabilization HIF-1α its...
Accumulated evidence shows that some phytochemicals provide beneficial effects for human health. Recently, a number of mechanistic studies have revealed direct interactions between and functional proteins play significant roles in exhibiting their bioactivities. However, binding selectivities to biological molecules are considered be lower due small simple structures. In this study, we found zerumbone, bioactive sesquiterpene, binds numerous with little selectivity. Similar heat-denatured...
Kaempferol (KMP), a flavonoid in edible plants, exhibits diverse pharmacological effects. Growing body of evidence associates extended lifespan with physical activity (PA) and sleep, but KMP's impact on these behaviors is unclear. This double-blind, placebo-controlled, crossover trial assessed effects PA sleep.
An anti-inflammatory triterpenoid, ursolic acid (UA), has recently been found unexpectedly to induce the release of a pro-inflammatory mediator in resting macrophages. In this study, we that topical applications UA mouse skin twice week for 2 weeks significantly enhanced mRNA expression cyclooxygenase (COX)-1, COX-2, and tumor necrosis factor-α, whereas its effect on promotion was unclear.
Hypoxic conditions in the body have been reported to occur aging and exercising muscles. It has suggested that a reduction ATP, due hypoxia, may contribute related declines muscle performance. In this study, we established hypoxic assay systems evaluated effects of 65 phytochemicals on intracellular ATP content C2C12 myotubes, more accurately determine their physiological activities. We found myotubes be reduced, under conditions. However, kaempferol markedly increased it systems, by...
Hypoxia can occur in daily life, and exercise is a potential trigger. Intense increases oxygen demand muscles, potentially compromising performance by reducing ATP resynthesis. Kaempferol (KMP) intracellular resynthesis hypoxic cellular models. We investigated the effects of KMP on utilization during general human population. Study 1 (Ramp-incremental cycling test): Overall, 20 men were randomized to four groups administrated placebo, 2.5, 10, or 25 mg for 8 days crossover design....
ABSTRACT Plants exposed to hypoxic conditions have been suggested produce more biologically active phytochemicals than those normal oxygen levels. Previously, we investigated 314 highland crop species and showed that the flavonoid kaempferol extracted from a quinoa grain markedly increased mitochondrial metabolism ATP production in environment vitro. Thus, hypothesized would be effective during exercise under harsh conditions, which anaerobic occurs. This study adopted double‐blind,...