A5028167558- Ovarian cancer diagnosis and treatment
- Fluid Dynamics Simulations and Interactions
- Endometrial and Cervical Cancer Treatments
- Skin and Cellular Biology Research
- Endometriosis Research and Treatment
- Liver Disease Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Erosion and Abrasive Machining
- Earthquake and Tsunami Effects
- Adipose Tissue and Metabolism
- Traumatic Brain Injury and Neurovascular Disturbances
- Coastal and Marine Dynamics
- Drug-Induced Adverse Reactions
- Cancer, Hypoxia, and Metabolism
- Environmental Chemistry and Analysis
- Hair Growth and Disorders
- Chemotherapy-related skin toxicity
- Organ and Tissue Transplantation Research
- Lung Cancer Treatments and Mutations
- Contact Dermatitis and Allergies
- Autoimmune Bullous Skin Diseases
- Cancer Treatment and Pharmacology
- Organ Transplantation Techniques and Outcomes
- Reproductive Biology and Fertility
- Cancer Immunotherapy and Biomarkers
Otsuka (Japan)
2013-2024
Kanzaki (Japan)
2023-2024
Saiseikai Shigaken Hospital
2013-2024
Iwate Medical University
2023-2024
University of Tsukuba
2018
Mizuho (Japan)
2008-2011
Rikkyo University
2007
Shiga University of Medical Science
1994-2006
Kagawa University
2003
Epson (United States)
2002
Kaempferol (KMP) is an important flavonoid in many fruits and vegetables. Preclinical studies on KMP have reported its pharmacological effects, including antimicrobial, antioxidant, anti-inflammatory, antitumor, antidiabetic, myocardial protective, neuroprotective effects. Additionally, some epidemiological revealed a negative association between the consumption of KMP-containing foods risk developing several disorders, such as cancer cardiovascular diseases. Thus, although large body...
Using a new method to measure the hardness of pericranial muscles, role muscle factors in tension-type headache was evaluated. In 223 normal healthy subjects, trapezius muscles 82±15 kPa/cm (mean±SD). The women, 92±17 kPa/cm, significantly greater than that men, 74±14 (P < 0.01). Trapezius were harder paraspinal posterior neck measured at level fifth cervical vertebra (71±13 kPa/cm; n = 26) but significant correlation did exist between these two groups (r 0.89, P 0.001). Muscle not show with...
Harlequin ichthyosis (HI), which is the most severe genodermatosis, caused by loss-of-function mutations in ABCA12, a member of ATP-binding cassette transporter family. To investigate pathomechanism HI and function ABCA12 protein, we generated ABCA12-deficient mice (Abca12 −/− ) targeting Abca12 . closely reproduce human phenotype, showing marked hyperkeratosis with eclabium skin fissure. Lamellar granule abnormalities defective ceramide distribution were remarkable epidermis. Skin...
Kaempferol (KMP) has numerous important biological functions, and we recently showed that it remarkably increased intracellular adenosine triphosphate (ATP) content in C2C12 myotubes under hypoxic conditions. Since ATP is generated by aerobic energy metabolism or anaerobic glycolysis, hypoxia inducible factor-1α (HIF-1α) been shown to be associated with metabolic remodeling causes shift from glycolysis response Here, investigate the effects of KMP conditions on stabilization HIF-1α its...
Accumulated evidence shows that some phytochemicals provide beneficial effects for human health. Recently, a number of mechanistic studies have revealed direct interactions between and functional proteins play significant roles in exhibiting their bioactivities. However, binding selectivities to biological molecules are considered be lower due small simple structures. In this study, we found zerumbone, bioactive sesquiterpene, binds numerous with little selectivity. Similar heat-denatured...
We compared the cytoarchitectural features used for cytologic diagnosis of endometrial adenocarcinoma (EC) using ThinPrep® (TPS = ThinPrep Sample) and BD SurePath™ (SPS SurePath preparations. In 20 patients, a direct sample Uterobrush was obtained. Nineteen cases EA one case carcinosarcoma were studied. TPS SPS performed according to manufacturer's recommendations. Moreover, after preparation, residual material also prepare an (TP–SPS ThinPrep–Surepath sample). The following points...
To investigate the distribution and role of macrophage inflammatory protein-1alpha (MIP-1alpha) in human endometrium during cyclic changes.Department Obstetrics Gynaecology, Shiga University Medical Science Hospital.Eighteen endometrial tissue specimens surgically resected or biopsied from women with normal menstrual cycles, without hormonal disorder diseases.By immunohistochemistry, using monoclonal antibodies (lambda delta 78 for MIP-1alpha CR3/43 leukocyte antigen-DR...
Abstract Problems in major components and structural materials nuclear power plants have often been caused by flow induced vibration corrosion their overlapping effects. In order to establish safe reliable plant operation, future problems for should be predicted based on combined analyses of dynamics they mitigated before becoming serious issues operation. Three approaches prepared predicting materials: 1. Computer program packages fatigue materials, 2. damage 3. wall thinning accelerated...
Although about half of the shield tunnel works done in world exist Japan, their product model has not been developed and detail construction related data are owned by engineers who worked at sites. Considering international contribution business chances, order to preserve precious for future use, we decide develop a representing construction. As its first step, investigated characteristics tunnels conceptual model. Then, implemented some part expanding IFC. We performed experiments...
Objective To investigate the management of women with asymptomatic ovarian masses, to determine appropriate duration follow up, and identify diagnostic indicators growing cysts. Design Review women's hospital records. Setting Tokyo Metropolitan Cancer Detection Center, Japan. Population Two hundred twenty‐five pre‐ postmenopausal a diagnosis cyst ≥6 cm in diameter normal serum level CA125, diagnosed between 1 October 1990 25 December 1991. Main outcome measure Change size as shown by...
Hypoxic conditions in the body have been reported to occur aging and exercising muscles. It has suggested that a reduction ATP, due hypoxia, may contribute related declines muscle performance. In this study, we established hypoxic assay systems evaluated effects of 65 phytochemicals on intracellular ATP content C2C12 myotubes, more accurately determine their physiological activities. We found myotubes be reduced, under conditions. However, kaempferol markedly increased it systems, by...
Problems in major components and structural materials nuclear power plants have often been caused by flow induced vibration corrosion their overlapping effects. In order to establish safe reliable plant operation, future problems for should be predicted based on combined analyses of dynamics they mitigated before becoming serious issues operation. Three approaches prepared predicting materials: 1. Computer program packages fatigue materials, 2. damage 3. wall thinning accelerated corrosion....
Abstract A prenatally diagnosed aneurysm of the vein Galen was presented in fetus a patient referred to our hospital at 31 weeks gestation. Ultrasonography demonstrated polyhydramnios, cardiomegaly, dilatation right atrium and superior vena cava, tricuspid valve regurgitation, hydrocephalus, large hypoechoic mass with blood flow suboccipital region. Skin edema shown thereafter. 3262‐g male delivered by cesarean 35 Computed tomography imaging region, after which thrombocytopenia appeared...
CADMAS-SURF/3D is a three-dimensional numerical wave tank under development which has recently been applied to some studies of wave-structure interaction. However problems have pointed out: for example it difficult determine the reasonable drag coefficient and grid dependency resistance remarkable. In this study we clarified using conventional calculation method examined influence on force. Next applicability with Dupuit-Forhhimer was investigated through comparison between experimental...
The troubles of major components and structural materials in nuclear power plants have often been caused by flow-induced vibration, corrosion, their overlapping effects. In order to establish safe reliable plant operation, it is required forecast future based on combined analyses flow dynamics corrosion prevent them at very early stages. Corrosion analysis models with three-dimensional heat transfer evaluate damage (e.g., stress cracking [SCC] flow-accelerated [FAC]) materials. are divided...
It is important to develop the Solid-Gas-Liquid coupling system for analyzing mechanism of failure structures on land by Tsunami. At first, numeric wave tank, whose name CADMAS-SURF/3D, improved correspond two phase incompressible fluid. This flow tank applied impulsive pressure problem. As a result, it confirmed that noise, which called Spike Noise, removed and accuracy result good agreement with single model. Next step, DEM method developed. The wall destruction test fluid conducted....