A5057775605- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Advanced Radiotherapy Techniques
- Bladder and Urothelial Cancer Treatments
- Lung Cancer Diagnosis and Treatment
- Effects of Radiation Exposure
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Management of metastatic bone disease
- Urinary and Genital Oncology Studies
- Medical Imaging Techniques and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Economic and Financial Impacts of Cancer
- Radiation Dose and Imaging
- Radiation Therapy and Dosimetry
- Cancer Immunotherapy and Biomarkers
- Metabolism, Diabetes, and Cancer
- Urinary Bladder and Prostate Research
- Renal cell carcinoma treatment
- Protein Kinase Regulation and GTPase Signaling
- Glioma Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Renal and related cancers
- PI3K/AKT/mTOR signaling in cancer
- Healthcare and Venom Research
Fox Chase Cancer Center
2016-2025
Radiation Oncology Associates
2020-2021
Cancer Research And Biostatistics
2021
Philadelphia University
2018
Creative Research Enterprises (United States)
2017
RTOG Foundation
2016
Temple University Hospital
2014
Medical University of South Carolina
2006-2010
Washington State University
2008
438 Background: Cisplatin-based neoadjuvant chemotherapy (NAC) followed by cystectomy or chemoradiation is the standard of care for urothelial carcinoma (UC) patients with MIBC. Both and have short long-term toxicity QOL implications. Mutations in DNA damage repair/response genes are associated pathologic downstaging after NAC. We hypothesized that a combination biomarker selection clinical staging would identify prospectively avoidance algorithm. Methods: conducted single-arm, phase II,...
The phosphatidylcholine-using phospholipase D (PLD) isoform PLD2 is widely expressed in mammalian cells and activated response to a variety of promitogenic agonists. In this study, active inactive hemagglutinin-tagged human (HA-PLD2) constructs were stably an EL4 cell line lacking detectable endogenous PLD1 or PLD2. overall goal the study was examine roles cellular signal transduction phenotype. HA-PLD2 confers PLD activity that by phorbol ester, ionomycin, okadaic acid. Proliferation Erk...
397 Background: Cisplatin-based neoadjuvant chemotherapy (NAC) followed by cystectomy (Cx) or chemoradiation (CRT) is the standard of care for urothelial carcinoma (UC) pts with muscle invasive bladder cancer (MIBC). Both Cx and CRT have potential short long-term toxicity QOL implications. Mutations in DNA damage repair/response genes are associated pathologic downstaging after NAC. Methods: We conducted a phase II, multi-institutional clinical trial (NCT02710734) to evaluate risk-adapted...
815 Background: Cisplatin-based neoadjuvant chemotherapy (NAC) followed by radical cystectomy (RC) or chemoradiation (CRT) is the standard of care for patients (pts) with muscle invasive bladder cancer (MIBC). Mutations in DNA damage repair genes enrich pathologic downstaging after NAC. In RETAIN-1, a risk-adapted approach was employed to identify cystectomy-sparing active surveillance (AS) following NAC, reporting 73% 2-year MFS rate. RETAIN-2 employs similar but incorporates...
The previously published single institution randomized prospective trial failed to show superiority in the 5-year biochemical and/or clinical disease failure (BCDF) rate with moderate hypofractionated intensity-modulated radiation therapy (H-IMRT) versus conventionally fractionated IMRT (C-IMRT). We now present 10-year outcomes using updated risk groups and definitions of failure.Men protocol-defined intermediate- high-risk prostate adenocarcinoma were randomly assigned receive C-IMRT (76 Gy...
Repair of injured renal epithelium is thought to be mediated by surviving proximal tubular cells (RPTC) that must dedifferentiate allow the proliferation and migration necessary for epithelial regeneration. RPTC then redifferentiate restore structure function. Current models suggest epidermal growth factor receptor (EGFR) activation required dedifferentiation characterized enhanced vimentin expression, decreased N-cadherin spindle morphology, loss apical-basal polarity after injury. Because...
The release of inflammatory cytokines has been implicated in the toxicity conventional radiotherapy (CRT). Transforming growth factor β (TGF-β) suggested to be a risk marker for pulmonary following radiotherapy. Pulsed low-dose rate (PLDR) is technique that involves spreading out dose into short pulses with breaks between reduce toxicities. We hypothesized more tolerable profile PLDR compared CRT may related differential expression such as TGF-β normal tissues. To address this, we analyzed...
Abstract Introduction To evaluate if interruptions of external beam radiation therapy impact outcomes in men with localized prostate cancer ( PC a). Methods We included a treated three‐dimensional conformal radiotherapy (3D‐ CRT ) or intensity‐modulated IMRT escalated dose (≥74 Gy 1.8 2 fractions) between 1992 and 2013 at an NCI ‐designated centre. Men receiving androgen deprivation were excluded. The non‐treatment day ratio NTDR was defined as the number days divided by total elapsed...
Purpose: We sought to compare changes in patient-reported quality of life (PRQOL) following stereotactic body radiation therapy (SBRT), high dose rate (HDR), and low (LDR) brachytherapy for prostate cancer. Materials Methods: International Prostate Symptom Score (IPSS), Sexual Health Inventory For Men (SHIM), Expanded cancer Index Composite Short Form (EPIC-26) were prospectively collected men with low/intermediate-risk treated at a single institution. used Generalized Estimating Equations...