A5083156256- Graphene and Nanomaterials Applications
- Nerve injury and regeneration
- Bone Tissue Engineering Materials
- Nanoplatforms for cancer theranostics
- Anesthesia and Neurotoxicity Research
- Nanoparticles: synthesis and applications
- Neuroscience and Neural Engineering
- Biosensors and Analytical Detection
- Bacterial Identification and Susceptibility Testing
- Water Quality Monitoring and Analysis
- Advanced Sensor and Energy Harvesting Materials
- Advanced Proteomics Techniques and Applications
- Carbon and Quantum Dots Applications
- 3D Printing in Biomedical Research
- Advanced MRI Techniques and Applications
- Tissue Engineering and Regenerative Medicine
- Magnetic and transport properties of perovskites and related materials
- Polydiacetylene-based materials and applications
- MXene and MAX Phase Materials
- Planarian Biology and Electrostimulation
- Photoreceptor and optogenetics research
- Atomic and Subatomic Physics Research
- Graphene research and applications
- Polymer composites and self-healing
- Electrospun Nanofibers in Biomedical Applications
Hospital Nacional de Parapléjicos
2015-2025
Servicio de Salud de Castilla La Mancha
2015-2025
Universidad Autónoma de Madrid
2020
Interface (United States)
2018
Graphene oxide (GO) assists a diverse set of promising routes to build bioactive neural microenvironments by easily interacting with other biomaterials enhance their bulk features or, alternatively, self-assembling toward the construction biocompatible systems specific three-dimensional (3D) geometries. Herein, we first modulate both size and available oxygen groups in GO nanosheets adjust physicochemical biological properties polycaprolactone–gelatin electrospun nanofibrous systems. The...
The increasing prevalence and high sanitary costs of lesions affecting the central nervous system (CNS) at spinal cord are encouraging experts in different fields to explore new avenues for neural repair. In this context, graphene its derivatives attracting significant attention, although their toxicity performance CNS vivo remains unclear. Here, subacute tissue response 3D flexible porous scaffolds composed partially reduced oxide is investigated when implanted injured rat cord. interest...
Graphene-based materials are revealing a great promise for biomedical applications and demonstrating attractiveness neural repair. In the context of tissue damage, dialogue between immune cells appears critical driving regeneration, thus making understanding their relations pivotal. Herein, acute response RAW-264.7 macrophages on nanostructured reduced graphene oxide (rGO) microfibers has been evaluated through analysis cell parameters including proliferation, viability, intracellular...
Neural tissue engineering approaches show increasing promise for the treatment of neural diseases including spinal cord injury, which an efficient therapy is still missing. Encouraged by both positive findings on interaction carbon nanomaterials such as graphene with components and necessity more guidance structures repair, we herein study potential reduced oxide (rGO) microfibers substrates growth in injured central tissue. Compact, bendable, conductive fibers are obtained. When coated...
Spinal cord injury (SCI) is characterized by the disruption of neuronal axons and creation an inhibitory environment for spinal tissue regeneration. For decades, researchers clinicians have been devoting a great effort to develop novel therapeutic approaches which include fabrication biocompatible implants that could guide neural repair in lesion site attempt recover functionality nervous tissue. In this context, although fiberlike structures hypothesized serve as topographical guidance...
We present the design, fabrication, and characterization of an implantable neural interface based on anisotropic magnetoresistive (AMR) magnetic-field sensors that combine reduced size high performance at body temperature. The are La0.67Sr0.33MnO3 (LSMO) as a ferromagnetic material, whose epitaxial growth has been suitably engineered to get uniaxial anisotropy large AMR output together with low noise even frequencies. LSMO different film thickness temperatures close 37 °C be explored find...
Despite the pharmacological arsenal approved for Multiple Sclerosis (MS), there are treatment-reluctant patients whom cell therapy appears as only therapeutic alternative. Myeloid-derived suppressor cells (MDSCs) immature of innate immunity able to control immune response and promote oligodendroglial differentiation in MS animal model experimental autoimmune encephalomyelitis (EAE). However, when isolated cultured purposes, MDSCs lose their beneficial immunomodulatory properties. To prevent...
Abstract Understanding neural physiopathology requires advances in nanotechnology‐based interfaces, engineered to monitor the functional state of mammalian nervous cells. Such interfaces typically contain nanometer‐size features for stimulation and recording as cell‐non‐invasive extracellular microelectrode arrays. In such devices, it turns crucial understand specific interactions cells with physicochemical electrodes, which could be designed optimize performance. Herein, versatile flexible...
Ordering neural cells is of interest for the development interfaces. The aim this work to demonstrate an easy‐to‐use, versatile, and cost/time effective laser‐based approach producing platforms that promote oriented growth. We use laser interferometry generate fringed channels with topography on partially reduced graphene oxide layers as a proof‐of‐concept substrate. study cell adhesion, morphology, viability, differentiation in cultures embryonic progenitor 9.4 μm period. Results evidence...
Spinal cord injury remains a challenge for both clinicians and scientists. Novel materials such as graphene oxide have arisen attractive alternatives the design of more efficient reparative platforms. On page 1861 Maria C. Serrano co-workers investigate sub-acute response rat injured spinal to 3D scaffolds aid progress in field.
ABSTRACT Multiple Sclerosis (MS) is a chronic, inflammatory disease of the central nervous system. Despite pharmacological arsenal approved for MS, there are treatment-reluctant patients whom cell therapy appears as only therapeutic alternative. Myeloid-derived suppressor cells (MDSCs) immature innate immune response able to immunosuppress T lymphocytes and promote oligodendroglial differentiation in experimental autoimmune encephalomyelitis (EAE), preclinical model MS. Culture devices need...