A5065312897- Estrogen and related hormone effects
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Magnetic properties of thin films
- Epigenetics and DNA Methylation
- Metal complexes synthesis and properties
- Lung Cancer Treatments and Mutations
- HER2/EGFR in Cancer Research
- Physics of Superconductivity and Magnetism
- Metal-Catalyzed Oxygenation Mechanisms
- Porphyrin Metabolism and Disorders
- Molecular Sensors and Ion Detection
- ZnO doping and properties
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- MicroRNA in disease regulation
- Glutathione Transferases and Polymorphisms
- Cancer Genomics and Diagnostics
- Magnetic confinement fusion research
- Chemical Synthesis and Reactions
- Histone Deacetylase Inhibitors Research
- Angiogenesis and VEGF in Cancer
- Glioma Diagnosis and Treatment
- Therapeutic Uses of Natural Elements
- Cancer Research and Treatments
Institute of Mental Health
2025
National Institute on Aging
2024
National Institutes of Health
2024
University of California, Los Angeles
2024
Florida Memorial University
2022-2024
Nethradhama Superspeciality Eye Hospital
2024
Creative Commons
2024
University of Burdwan
2019-2023
University of Kalyani
2003-2023
Florida International University
2013-2023
Abstract Here we report corin, a synthetic hybrid agent derived from the class I HDAC inhibitor (entinostat) and an LSD1 (tranylcypromine analog). Enzymologic analysis reveals that corin potently targets CoREST complex shows more sustained inhibition of activity compared with entinostat. Cell-based experiments demonstrate exhibits superior anti-proliferative profile against several melanoma lines cutaneous squamous cell carcinoma to its parent monofunctional inhibitors but is less toxic...
MicroRNAs have been implicated in many critical cellular processes including apoptosis. We previously found that apoptosis pancreatic cancer cells was induced by adamantyl retinoid-related (ARR) molecule 3-Cl-AHPC. Here we report 3-Cl-AHPC-dependent involves regulating a number of microRNAs miR-150* and miR-630. 3-Cl-AHPC stimulated expression caused decreased c-Myb IGF-1R the cells. 3-Cl-AHPC-mediated reduction resulted diminished binding with Bcl-2 promoters, thereby causing repression...
A simple and straightforward route for the synthesis of thioethers, thioesters, vinyl thioethers thio-Michael adducts has been demonstrated using silica nanoparticles (NPs) as a reusable catalyst via 1,2-addition thiols to alkenes, alkynes alkyl/acyl halides, 1,4-addition conjugated alkenes at room temperature.
Strain-promoted click chemistry of nucleosides and nucleotides with an azido group directly attached to the purine pyrimidine rings various cyclooctynes in aqueous solution at ambient temperature resulted efficient formation (3 min 3 h) fluorescent, light-up, triazole products. The 2- 8-azidoadenine reacted fused cyclopropyl cyclooctyne, dibenzylcyclooctyne, or monofluorocyclooctyne produce products functionalized hydroxyl, amino, N-hydroxysuccinimide, biotin moieties. 5-azidouridine...
17β-Oestradiol (E2)-induced reactive oxygen species (ROS) have been implicated in regulating the growth of breast cancer cells. However, underlying mechanism this is not clear. Here we show how ROS through a novel redox signalling pathway involving nuclear respiratory factor-1 (NRF-1) and p27 contribute to E2-induced MCF-7 Chromatin immunoprecipitation, qPCR, mass spectrometry, western blot, colony formation, cell proliferation, assay, immunofluorescence microscopy were used study role...
We have previously shown nuclear respiratory factor 1 (NRF1)-mediated transcriptional programming of mitobiogenesis contributes to estrogen-induced breast cancer through modulating cell cycle progression. In this study, we report a new role NRF1 that goes beyond mitobiogenesis. Specifically, novel oncogenic function supporting its causative in development and The gain and/or treatment with 17β-estradiol (E2) produced heterogeneous stem (BCSC)-like subsets composed more than 10 distinct...
Background: An erythrocyte sedimentation rate (ESR) is a nonspecic laboratory investigation, which not specic test for diagnosis of any disease. However an increase level ESR may indicate presence inammation, infection, rheumatologic disease, or malignancy. For monitoring the there has been no accepted standard control sample. Studies are available relating to values different diseases; however study was performed compare blood mixed with TSC and EDTA in area. So, this aimed two commonly...
Vascular diseases, including peripheral arterial disease (PAD), pulmonary hypertension, and atherosclerosis, significantly impact global health due to their intricate relationship with vascular remodeling. This process, characterized by structural alterations in resistance vessels, is a hallmark of heightened seen these disorders. The influence environmental estrogenic endocrine disruptors (EEDs) on the vasculature suggests potential exacerbation alterations. Our study employs an integrative...
AIM: Cyclophosphamide (CP) is one of the most widely used alkylating antineoplastic agents that damage normal cells while killing cancerous in vivo. The use CP treating cancer patients limited due to its severe toxicities induced mainly by oxidative stress. Diphenylmethyl selenocyanate a synthetic organoselenium compound shown act as potent antioxidant chemically murine toxicity and carcinogenesis models In present study, this has been evaluated for protective potential against CP-induced...
Abstract An exploration of an abiotic approach to spirocalcaridines A and B is described centered on electrophile‐induced dearomatizing spirocyclization aryl enyne derivatives. Elaboration the α‐iodoenone through Ullmann‐like, copper‐catalyzed amidation provided a formamide, which upon treatment with methylamine undergoes dienol‐arene rearrangement provide corresponding kealiinine‐like framework. This observation suggests possible biosynthetic links between spirocalcaridine naphthimidazole...
Treatment of propargyl ureas or guanidines with iodosobenzene diacetate results in an oxidative tandem amination/etherification dearomatizing spirocyclization. This transformation leads directly to the complete framework Leucetta alkaloids, spirocalcaridine A and B.
Short total syntheses of the Leucetta-derived alkaloids, kealiinines A–C, have been accomplished using an intramolecular Friedel–Crafts–dehydration sequence a bis benzylic diol. The precursor diol was obtained through series position-specific Grignard reactions from 1-methyl-4,5-diiodoimidazole. C2-Azidation and hydrogenation azide then provided reported structures A–C. While 1H NMR data did not completely match for these materials, HPLC were consistent with assigned structure alkaloids.
An intriguing effect of short-term caloric restriction (CR) is the expansion certain stem cell populations, including muscle cells (satellite cells), which facilitate an accelerated regenerative program after injury. Here, we utilized MetRSL274G (MetRS) transgenic mouse to identify liver-secreted plasminogen as a candidate for regulating satellite during CR. Knockdown circulating prevents Furthermore, loss receptor KT (Plg-RKT) also sufficient prevent CR-related expansion, consistent with...
Objectives: This study was conducted to examine whether the potentized homeopathic remedy Carcinosin 200, fed alone and in combination with Chelidonium has differential protective effects against p-dimethylaminoazobenzene (p-DAB)–induced hepatocarcinogenesis mice. Design: Liver tumors were induced mice through chronic feeding of p-DAB (initiator) phenobarbital (PB, promoter). The divided into two subgroups: (1) one Alcohol 200 served as controls; (2) other or several sets. relative efficacy...
We report on the surface antiferromagnetic (AFM) domain imaging of prototype antiferromagnet NiO(100) using an electron-microscopy-based laboratory method. Coherently exchange-scattered electrons from AFM lattice are utilized in a low-energy electron microscope to resolve structure. Direct comparison with x-ray magnetic linear dichroism photoemission microscopy demonstrates complimentary nature. High sensitivity combined improved spatial resolution this method enables studying nanosized...
Pancreatic carcinoma has a dismal prognosis as it often presents locally advanced or metastatic. We have found that exposure to adamantyl-substituted retinoid-related (ARR) compounds 3-Cl-AHPC and AHP3 resulted in growth inhibition apoptosis induction PANC-1, Capan-2, MiaPaCa-2 pancreatic cancer cell lines. In addition, inhibited induced spheres derived from the CD44(+)/CD24(+) (CD133(+)/EpCAM(+)) stem-like population isolated 3-Cl-AHPC-induced was preceded by decreasing expression of...
Microvascular lesions resulting from endothelial cell dysfunction are produced in the brain, lung, kidney, and retina of patients complex chronic diseases. The environmental molecular risk factors which may contribute development microvascular damage unclear. mechanism(s) responsible for initiating remain poorly defined, although several inciting have been proposed, including toxicants-induced oxidative stress. Enhanced neovascularization has implicated either or progression proliferative...
Groundwater arsenic (As) has affected millions of people globally distributed over 20 countries. In parts West Bengal (India) and Bangladesh alone, 100 million are at risk, but supply As-free water is grossly inadequate. Attempts to remove As by using orthodox medicines have mostly been unsuccessful. A potentized homeopathic remedy, Arsenicum Album-30, was administered a group thereafter the contents in their urine blood were periodically determined. The activities various toxicity marker...