A5014269860- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Systemic Sclerosis and Related Diseases
- Blood disorders and treatments
- Connective Tissue Growth Factor Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Eosinophilic Disorders and Syndromes
- Extracellular vesicles in disease
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2018-2023
Vita-Salute San Raffaele University
2018-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2023
Platelet microparticles from patients with systemic sclerosis prompt endothelial cell activation, neutrophil recruitment, and lung fibrosis.
<h3>Background</h3> Neutrophil activation and the generation of neutrophils extracellular traps (NETs) contribute to vascular damage thrombosis in antiphospholipid syndrome (aPS). We reported that Low molecular weight heparin (LMWH) prevent neutrophil induced by P-selectin expressed activated platelets [1, 2] jeopardize healthy subjects ability generate NETs mobilize granule contents [3]. <h3>Objectives</h3> To investigate whether LMWH, used on empirical bases high-risk patients, regulate...
<h3>Background</h3> Persistent oxidative stress and unrelenting vascular inflammation are hallmarks of Systemic Sclerosis (SSc). Platelet-derived microparticles (PD-uP) that express a bioactive redox-dependent moiety, HMGB1 accumulate in the peripheral blood patients with SSc. <h3>Objectives</h3> To verify whether PD-uP might represent biomarker SSc clinical involvement their biological actions is regulated by environmental redox. <h3>Methods</h3> Fifty-four were enrolled so far. Twenty...