A5067196863- PARP inhibition in cancer therapy
- SARS-CoV-2 and COVID-19 Research
- Trauma Management and Diagnosis
- Protein Degradation and Inhibitors
- Cardiovascular Effects of Exercise
- Shoulder and Clavicle Injuries
- CRISPR and Genetic Engineering
- Chromatin Remodeling and Cancer
- Mosquito-borne diseases and control
- Wireless Body Area Networks
- Single-cell and spatial transcriptomics
- Cardiac Fibrosis and Remodeling
- Pluripotent Stem Cells Research
- 3D Printing in Biomedical Research
- RNA Interference and Gene Delivery
- Tissue Engineering and Regenerative Medicine
- Traumatic Ocular and Foreign Body Injuries
- Plant Virus Research Studies
- Electrospun Nanofibers in Biomedical Applications
- Restraint-Related Deaths
- Cardiac electrophysiology and arrhythmias
Stanford University
2022-2025
California Institute for Regenerative Medicine
2023
Gladstone Institutes
2020-2022
Although coronavirus disease 2019 (COVID-19) causes cardiac dysfunction in up to 25% of patients, its pathogenesis remains unclear. Exposure human induced pluripotent stem cell (iPSC)-derived heart cells severe acute respiratory syndrome 2 (SARS-CoV-2) revealed productive infection and robust transcriptomic morphological signatures damage, particularly cardiomyocytes. Transcriptomic disruption structural genes corroborates adverse morphologic features, which included a distinct pattern...
ABSTRACT Although COVID-19 causes cardiac dysfunction in up to 25% of patients, its pathogenesis remains unclear. Exposure human iPSC-derived heart cells SARS-CoV-2 revealed productive infection and robust transcriptomic morphological signatures damage, particularly cardiomyocytes. Transcriptomic disruption structural proteins corroborated adverse morphologic features, which included a distinct pattern myofibrillar fragmentation numerous iPSC-cardiomyocytes lacking nuclear DNA. Human autopsy...
Abstract SARS-CoV-2 infection of human cells is initiated by the binding viral Spike protein to its cell-surface receptor ACE2. We conducted a targeted CRISPRi screen uncover druggable pathways controlling cells. found that BRD2 required for ACE2 transcription in lung epithelial and cardiomyocytes, inhibitors currently evaluated clinical trials potently block endogenous expression cells, including those nasal epithelia. Moreover, pharmacological inhibition with drug ABBV-744 inhibited...
<title>Abstract</title> <underline>Purpose </underline>To evaluate frequency and timing of post-discharge complications in patients with traumatic rib fractures undergoing operative or nonoperative management. <underline>Methods </underline>We retrospectively reviewed adult admitted to a Level 1 trauma center from 1/2020-12/2021. Outcomes included rib-related complications, pneumonia within month, new diagnosis opioid- alcohol-use disorder, all-cause mortality. Patients were stratified on...
Abstract Cell-derived matrices (CDMs) isolated from cultured cells provide complex and tissue-specific biochemical physical cues derived the extracellular matrix (ECM) that are lacking in typical tissue culture environments. However, current methods enhance ECM adhesion thickness via introduction promotion of singular proteins, skewing composition, confounding comparisons between CDMs. Here we developed a protocol enhances CDM stability deposition, respectively, by combining an...