A5077922476- Systemic Sclerosis and Related Diseases
- Monoclonal and Polyclonal Antibodies Research
- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
- Celiac Disease Research and Management
- Cytomegalovirus and herpesvirus research
- Parvovirus B19 Infection Studies
- Rheumatoid Arthritis Research and Therapies
- Hearing, Cochlea, Tinnitus, Genetics
- Dermatological and COVID-19 studies
- Immune Cell Function and Interaction
- Viral gastroenteritis research and epidemiology
- Vestibular and auditory disorders
- Spondyloarthritis Studies and Treatments
- Autoimmune and Inflammatory Disorders Research
- Salivary Gland Disorders and Functions
- Connective Tissue Growth Factor Research
- Cancer-related molecular mechanisms research
- Dermatologic Treatments and Research
- Atherosclerosis and Cardiovascular Diseases
- Immunotherapy and Immune Responses
- Galectins and Cancer Biology
- T-cell and Retrovirus Studies
- Eosinophilic Disorders and Syndromes
University of Genoa
2012-2022
Bambino Gesù Children's Hospital
2016-2018
Istituto Giannina Gaslini
2006-2015
Ospedale dei Bambini Vittore Buzzi
2015
Institut Paoli-Calmettes
2001
University of Pisa
1986-1994
Sapienza University of Rome
1993
Tufts University
1990
Autoimmune pancreatitis is characterized by an inflammatory process that leads to organ dysfunction. The cause of the disease unknown. Its autoimmune origin has been suggested but never proved, and little known about pathogenesis this condition.
A unique subset of anti-DNA antibodies enters living cells, interacts with DNase 1, and inhibits endonuclease activity, before their nuclear localization subsequent attenuation apoptosis. We now report that endocytosis these immunoglobulins is mediated by cell surface binding to brush border myosin (myosin 1). Cellular entry internalization via this receptor provides initial contact for sorting translocate the pore enter nucleus, interact 1 within cytoplasm, or recycle back surface. This...
Celiac disease is a small intestine inflammatory disorder with multiple organ involvement, sustained by an inappropriate immune response to dietary gluten. Anti-transglutaminase antibodies are typical serological marker in patients active disease, and may disappear during gluten-free diet treatment. Involvement of infectious agents innate immunity has been suggested but never proven. Molecular mimicry one the mechanisms that links infection autoimmunity.In our attempt clarify pathogenesis...
Background Systemic sclerosis is an autoimmune disease characterized by immunological abnormalities, vascular damage, and fibroblast proliferation. We have previously shown that a molecular mimicry mechanism links antibodies against the human-cytomegalovirus-derived protein UL94 to pathogenesis of systemic sclerosis. The epitope shows homology with NAG-2, surface molecule highly expressed on endothelial cells. Anti-UL94 peptide purified from patients' sera induce apoptosis cells upon...
p75/AIRM-1 is a recently identified inhibitory receptor expressed by natural killer and myeloid cells displaying high homology with CD33. Crosslinking of or CD33 has been shown to sharply inhibit the in vitro proliferation both normal chronic leukemias. In this study, we analyzed acute leukemic for expression p75/AIRM-1. marked M5 (11/12) M4 (2/2) but not M1, M2, M3 subtypes according French–American–British classification. Cell samples from 12 leukemias were cultured presence...
Internucleosomal DNA fragmentation following the activation of endonucleases is common end point apoptosis. DNase I, a Ca2+ / Mg2+-dependent endonuclease ubiquitously expressed in mammalian tissues, believed to play role this process. To analyze vivo function enzyme human cells, we have generated cell line with targeted disruption I gene, as well several stable lines which overexpress gene. Inactivation gene was obtained Jurkat T clone JA3, characterized by high susceptibility apoptotic...
Summary Background Chronic idiopathic urticaria is a common skin disorder characterized by recurrent, transitory, itchy weals for more than 6 weeks. An autoimmune origin has been suggested based on the findings of auto‐antibodies (Abs) directed against either α subunit high‐affinity IgE receptor or molecule in nearly half patients. Objective To identify other autoantigen targets patients with chronic urticaria. Methods We used pooled IgG derived from 133 to screen random peptide library...
Psoriatic arthritis (PsA) is an inflammatory whose pathogenesis poorly understood; it characterized by bone erosions and new formation. The diagnosis of PsA mainly clinical diagnostic biomarkers are not yet available. aim this work was to clarify some aspects the disease identify specific gene signatures in paired peripheral blood cells (PBC) synovial biopsies patients with PsA. Moreover, we tried that can be used practice.PBC 10 were study expression using Affymetrix arrays. values...
Endothelin-1 (ET-1) plays a pivotal role in vasoconstriction, fibrosis, and inflammation, the key features of systemic sclerosis (SSc). ET-1 receptors (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msub><mml:mrow><mml:mtext>ET</mml:mtext></mml:mrow><mml:mrow><mml:mtext>A</mml:mtext></mml:mrow></mml:msub></mml:mrow></mml:math>and<mml:math...
Behçet disease (BD) is a chronic inflammatory multisystem characterized by oral and genital ulcers, uveitis, skin lesions. Disease etiopathogenesis still unclear. We aim to elucidate some aspects of BD pathogenesis identify specific gene signatures in peripheral blood cells (PBCs) patients with active using novel expression network analysis. 179 genes were modulated 10 PBCs when compared healthy donors. Among differentially expressed the top enriched function was immune response,...
Systemic sclerosis (SSc) is a rare connective tissue disease characterized by three pathogenetic hallmarks: vasculopathy, dysregulation of the immune system, and fibrosis. A particular feature SSc increased frequency some types malignancies, namely breast, lung, hematological malignancies. Moreover, may also be paraneoplastic disease, again indicating strong link between cancer scleroderma. The reason this association still unknown; therefore, we aimed at investigating whether genetic or...
Background Psoriatic arthritis (PsA) is a chronic inflammatory disease of unknown origin, characterized by erosions and new bone formation. Diagnosis PsA mainly clinical there are no biomarkers available. Moreover in autoantibodies have not been described so far. Indeed an autoimmune origin has suggested but never proven. Aim the study was to investigate possible presence typically associated with PsA. Methods We used pooled IgG immunoglobulins derived from 30 patients screen random peptide...
Fibromyalgia is a chronic disorder characterized by widespread pain and several non-pain symptoms. Autoimmunity, small fiber neuropathy neuroinflammation have been suggested to be involved in the pathogenesis of disease. We investigated gene expression profile peripheral blood mononuclear cells obtained from ten patients healthy subjects. Of 545,500 transcripts analyzed, 1673 resulted modulated fibromyalgic patients. The majority these genes are biological processes pathways linked clinical...
Human cytomegalovirus (hCMV) is involved in the pathogenesis of atherosclerosis. We have previously shown patients with atherosclerosis that antibodies directed against hCMV-derived proteins US28 and UL122 are able to induce endothelial cell damage apoptosis non-stressed cells through cross-rection normally expressed surface molecules. Our aim was dissect molecular basis such interaction investigate mechanisms linking innate immunity atherosclerosis.We analysed gene expression profiles...
Background . Behçet’s disease (BD) is a chronic inflammatory multisystem characterized by oral and genital ulcers, uveitis, skin lesions. MicroRNAs (miRNAs) are key regulators of immune responses. Differential expression miRNAs has been reported in several autoimmune diseases; however, their role BD not fully elucidated. We aimed to identify miRNA signatures associated with investigate potential implication the pathogenesis. Methods microarray analysis was performed blood cells patients...
Primary Sjögren’s syndrome (pSjS) is a chronic systemic autoimmune disorder, primarily affecting exocrine glands; its pathogenesis still unclear. Long non-coding RNAs (lncRNAs) are thought to play role in the of diseases and comprehensive analysis lncRNAs expression pSjS lacking. To this aim, more than 540,000 human transcripts, including those ascribed 50,000 profiled at same time, cohort 16 peripheral blood mononuclear cells PBMCs samples (eight eight healthy subjects). A complex network...