A5023473529- Tea Polyphenols and Effects
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Adipose Tissue and Metabolism
- T-cell and B-cell Immunology
- Chemokine receptors and signaling
- NF-κB Signaling Pathways
- Cell Adhesion Molecules Research
- Immune Cell Function and Interaction
- Cell death mechanisms and regulation
- Diet and metabolism studies
- Fungal Biology and Applications
- Virus-based gene therapy research
- Medicinal Plant Pharmacodynamics Research
- Trace Elements in Health
- Regulation of Appetite and Obesity
- Cytokine Signaling Pathways and Interactions
- Atherosclerosis and Cardiovascular Diseases
- Estrogen and related hormone effects
- Biochemical Analysis and Sensing Techniques
- Tryptophan and brain disorders
- Connexins and lens biology
- Silymarin and Mushroom Poisoning
- Plant Toxicity and Pharmacological Properties
- Dietary Effects on Health
Shizuoka University
2013-2024
Meiji Gakuin University
1990-1994
To elucidate the inhibiting mechanisms of fat accumulation by catechins, caffeine, and epigallocatechin gallate (EGCG), ICR mice were fed diets containing either 0.3% catechins or 0.1% EGCG and/or 0.05% caffeine for 4 weeks. After feeding, intraperitoneal adipose tissues weights significantly lower in + groups compared to controls. Hepatic fatty acid synthase (FAS) activity group was lower, activities acyl-CoA oxidase (ACO) carnitine palmitoyltransferase-II (CPT-II) higher, control group....
Significance Maternal child neglect is an increasingly prevalent public health issue, but the underlying biologic processes causing this phenomenon are still largely unknown. This study examines prenatal environment of mice that later exhibit neglectful behavior. We have found that, in mice, factors determining phenotype a mother present during her own fetal period. evidence maternal prolactin (PRL) could be key factor for generating nurturing behavior offspring by activating neural circuits...
Although green tea is considered to be a healthy beverage, hepatotoxicity associated with the consumption of extract has been reported. In present study, we characterized in rats and explored responsible mechanism. Six-week-old IGS received single intraperitoneal (ip) injection 200 mg/kg (THEA-FLAN 90S). At 8, 24, 48 72 hrs 1 3 months after exposure, liver damage was assessed by using blood-chemistry, histopathology, immunohistochemistry detect cell death (TUNEL caspase-3) proliferative...
Epidemiological studies have indicated that a disturbed circadian rhythm resulting from night-shift work is potential risk factor for breast cancer. However, the mechanism of increased cancer by remains unclear, and there been few in vivo conducted to definitively associate two factors. In this study, BJMC3879Luc2 mouse cells were transplanted into BALB/c mice. Mice maintained under lighting conditions modeled two-shift system investigated effect light/dark cycle disruption on tumor growth...
Atherosclerosis is one of the diseases related to metabolic syndrome which caused by obesity. Previous reports have shown that green tea and its components anti-obesity effect. We examined whether catechins caffeine can prevent development atherosclerosis oral administration, singly or in combination model mice. Results demonstrated number atherosclerotic regions aorta was significantly reduced combined treatment, area also improved. Serum HDL-C increased single but no effect on TG TC any...
We previously reported that social isolation stimulated a stress response leading to increasing plasma corticosterone level and disruption of the hepatic lipid metabolism-related pathway, without changing body organ weights, in mice after 4 weeks stress, compared with grouped-housing control (5 mice/cage). In this study, we evaluated effects for an extended period on physiologic changes male C57BL/6J mice. Plasma was reduced 13 weeks, indicating might adapt stress. However, visceral fat...
To elucidate effects of catechins and caffeine on lipid metabolism in adipocytes identify the mechanism action, differentiated 3T3-L1 were incubated culture media containing at 1, 2.5, 5, 10 µg/mL 50 100 µg/mL, singly or combination, for 8 days. Intracellular accumulation glycerol-3-phosphate dehydrogenase activity strongly suppressed by combination treatment. The mRNA expression PPARɤ, GLUT4, HSL, UCP-1, TMEM26 significantly increased combined groups. These findings suggest that treatment...
A toxin and related compounds were isolated from a poisonous mushroom Tricholoma ustale. Their structures determined by analyses of the spectral data synthesis.
ABSTRACT To clarify the details of anti‐obesity effect theanine, γ‐glutamylethylamide, female ICR mice were fed diets containing theanine at concentrations 0.01, 0.02, 0.04, 0.08 and 0.16% for 16 weeks. Bodyweight food intake in measured every 4 weeks, several organs intraperitoneal adipose tissues (IPAT) weighed after feeding. In addition, lipid levels serum liver analyzed. As a result, bodyweight increase weight IPAT significantly reduced 0.04% compared with controls, but not other diets....
A single dominant gene on chromosome 18, Mtv-2, controls both the early appearance of mammary tumors and expression mouse tumor virus (MMTV) in milk. congenic DDD strain, DDD/1-Mtv-2/Mtv-2 (DDD-Mtv-2), was developed by introducing this from GRS/AJms (GR) into DDD/1 mice repeating 12 backcrosses subsequent inbreeding using as a marker for selection. Southern blot analysis liver DNA resulting with EcoRI MMTV-U3 prove revealed that two fragments corresponding to Mtv-2 were specifically...
Fas(lpr) (lpr) and Fas(lprcg) (lpr(cg)) are allelic mutations of the Fas gene that is involved in apoptosis or programmed cell death. Lpr greatly reduces expression functional lpr(cg) expresses death domain-disabled, non-functional on surface. C3H/HeJ mice congenic for (C3H-lpr(cg)) were established compared with C3H/HeJ-lpr/lpr (C3H-lpr) their immunological pathological features. Lymphadenopathy, splenomegaly, development CD4- CD8- B220+ double-negative (DN) T cells, renal pathology,...