A5057826873- Retinal Development and Disorders
- Metabolism and Genetic Disorders
- Carcinogens and Genotoxicity Assessment
- Retinal Diseases and Treatments
- Retinoids in leukemia and cellular processes
- Hemoglobinopathies and Related Disorders
- Connexins and lens biology
- Bone health and treatments
- Cancer, Lipids, and Metabolism
- Effects and risks of endocrine disrupting chemicals
- Parathyroid Disorders and Treatments
- Lipoproteins and Cardiovascular Health
- Toxic Organic Pollutants Impact
- Fatty Acid Research and Health
- Cancer and Skin Lesions
- Liver Disease Diagnosis and Treatment
- Diabetes and associated disorders
- Cancer Risks and Factors
- Cancer-related Molecular Pathways
- Pituitary Gland Disorders and Treatments
- Diet and metabolism studies
- Mitochondrial Function and Pathology
- Osteomyelitis and Bone Disorders Research
- Animal testing and alternatives
- Immunodeficiency and Autoimmune Disorders
Mukogawa Women's University
2017-2024
Kansai Medical University
2008-2017
National Institutes of Health
2005-2013
National Institute of Environmental Health Sciences
2004-2013
Astellas Pharma (Japan)
2005-2009
Daiwa Pharmaceutical Co. (Japan)
1992-2004
Tottori University
1989
Resveratrol (Res; 3,4',5-trihydroxy-trans-stilbene), which is a polyphenol found in grapes, can block cell proliferation and induce growth arrest and/or death several types of cancer cells. However, the precise mechanisms by Res exerts anticancer effects remain poorly understood. blocked both anchorage-dependent -independent HT-29 COLO 201 human colon cells dose- time-dependent manner. Annexin V staining Western blot analysis revealed that induced apoptosis accompanied an increase Caspase-8...
Purpose. Retinal degeneration induced by sodium iodate (NaIO3) in mice was evaluated morphologically. Methods. Male and female ICR C57BL were intraperitoneally administered 100 mg/kg NaIO3 at 7 weeks of age, killed 6, 12, 24 hrs, 3, 28 days after the treatment. Retinas examined histologically, ultrastructurally, immunohistochemically, TUNEL method. Results. evoked all NaIO3- treated mice. The primary site damage appeared retinal pigment epithelial (RPE) cells followed photoreceptor cell...
The mammary gland of laboratory rodents is an important organ for the evaluation effects xenobiotics, especially those that perturb hormonal homeostasis or are potentially carcinogenic. Mammary cancer a leading cause human mortality and morbidity worldwide subject major research efforts utilizing rodent models. Zymbal’s, preputial, clitoral glands standard tissues evaluated in animal models enable risk assessment xenobiotics. A widely accepted utilized international harmonization...
Caffeine (1,3,7-trimethylxanthine) is a popular mild central nervous system stimulant found in the leaves, seeds and fruits of various plants foodstuffs such as coffee, tea, chocolate, among others. widely used not associated with severe side effects when consumed at relatively low doses. Although rarely observed, overdoses can occur. However, only few fatal caffeine intoxication cases have been reported literature. Herein, we report pathological examination results information on...
The International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats Mice proposal (INHAND) has been operational since 2005. A Global Editorial Steering Committee manages the overall objectives project, development harmonized terminology each organ system is responsibility Organ Working Groups, drawing upon experts from North America, Europe, Japan. Great progress made with 9 systems published to date--respiratory, hepatobiliary, urinary, central/peripheral nervous...
Although green tea is considered to be a healthy beverage, hepatotoxicity associated with the consumption of extract has been reported. In present study, we characterized in rats and explored responsible mechanism. Six-week-old IGS received single intraperitoneal (ip) injection 200 mg/kg (THEA-FLAN 90S). At 8, 24, 48 72 hrs 1 3 months after exposure, liver damage was assessed by using blood-chemistry, histopathology, immunohistochemistry detect cell death (TUNEL caspase-3) proliferative...
Results from previously published animal studies suggest that prenatal and postnatal exposure to dioxin dioxin-like compounds (DLCs) may profoundly affect the reproductive system of both sexes via endocrine disruption. In present work, we evaluate toxicity carcinogenicity various DLCs, with an emphasis on their effect organs, induced by chronic female adult Harlan Sprague-Dawley rats. This investigation represents part initiative National Toxicology Program determine relative potency...