A5000307829- Luminescence and Fluorescent Materials
- Graphene research and applications
- Graphene and Nanomaterials Applications
- Carbon Nanotubes in Composites
- Nanoplatforms for cancer theranostics
- Porphyrin and Phthalocyanine Chemistry
- Fullerene Chemistry and Applications
- Carbohydrate Chemistry and Synthesis
- Nanoparticles: synthesis and applications
- Nanoparticle-Based Drug Delivery
- Carbon and Quantum Dots Applications
- Glycosylation and Glycoproteins Research
- Molecular Sensors and Ion Detection
- RNA Interference and Gene Delivery
- Photochemistry and Electron Transfer Studies
- Advanced Cellulose Research Studies
- Nanomaterials for catalytic reactions
- Metabolism, Diabetes, and Cancer
- Orthopedic Infections and Treatments
- Advanced biosensing and bioanalysis techniques
- Polysaccharides and Plant Cell Walls
- Laser-Ablation Synthesis of Nanoparticles
- Pancreatic function and diabetes
- 2D Materials and Applications
- Synthesis and Catalytic Reactions
University of Florence
2014-2024
National Interuniversity Consortium of Materials Science and Technology
2020-2023
The University of Texas MD Anderson Cancer Center
2019
Institute for the Chemistry of OrganoMetallic Compounds
2014
Liquid-phase exfoliation (LPE) in aqueous solutions provides a simple, scalable, and green approach to produce 2D materials. By combining atomistic simulations with experiments, the interaction between surfactant layer at molecular scale can be better understood. In this work, two different dyes, corresponding rhodamine B base (Rbb) phenylboronic acid BODIPY (PBA-BODIPY) derivative, are employed as dispersants exfoliate graphene hexagonal boron nitride (hBN) through sonication-assisted LPE....
A donor–acceptor dyad composed of a BF2-chelated dipyrromethene (BODIPY) and C60 fullerene has been newly synthesized characterized. The two moieties are linked by direct addition an azido substituted BODIPY on the C60, producing imino–fullerene–BODIPY adduct. photoinduced charge transfer process in this system was studied ultrafast transient absorption spectroscopy. Electron toward found to occur selectively exciting both chromophore at 475 nm unit 266 time scale few picoseconds, but...
A doxorubicin/metformin carrier for chemotherapy based on oxidized MWCNTs. Efficacy <italic>in vitro</italic> and vivo</italic>.
Covalent functionalization of graphene oxide (GO) with boron dipyrromethenes (BODIPYs) was achieved through a facile synthesis, affording two different GO-BODIPY conjugates where the main difference lies in nature spacer and type bonds between components. The use long but flexible afforded strong electronic interactions ground state. This drastically altered light absorption BODIPY structure impeded its selective excitation. In contrast, utilisation short, rigid based on boronic esters...
The bioimaging of cancer cells by the specific targeting overexpressed biomarkers is an approach that holds great promise in identification selective diagnostic tools. Tumor-associated human carbonic anhydrase (hCA) isoforms IX and XII have been considered so far as well-defined biomarkers, with their expression correlating progression aggressiveness. Therefore, availability highly performant fluorescent tools tailored for able to efficiently visualize such key targets high demand. We report...
The progress of the chemistry carbon nanotubes (CNT) and graphene derivatives [mainly oxide (GO)] has produced a number technologically advanced drug delivery systems (DDS) that have been used in field nanomedicine, mostly studies related to oncology. However, such demanding research requires continuous improvements terms efficiency, selectivity versatility. loading two, or more, bioactive components on same nanoparticle offers new possibilities for treating cancer, efficiently addressing...
Colorectal cancer is the third most commonly occurring in men and second women worldwide. We have recently reported that curcuminoid complexes labelled with gallium-68 demonstrated preferential uptake HT29 colorectal K562 lymphoma cell lines compared to normal human lymphocytes. In present study, we report a new gallium-68-labelled curcumin derivative (68Ga-DOTA-C21) its initial validation as marker for early detection of cancer. The precursor non-radioactive were synthesized deeply...
The custom functionalization of a graphene surface allows access to engineered nanomaterials with improved colloidal stability and tailored specific properties, which are available be employed in wide range applications ranging from materials life science. high area their intrinsic physical biological properties make reduced oxide unique for the bioactive molecules by exploiting different chemistries. In this work, preparation (on gram scale) derivatives functionalized well-known...
The increasing resistance of bacteria to conventional antibiotics represents a severe global emergency for human health. broad-spectrum antibacterial activity silver has been known long time, and at the nanoscale shows enhanced activity. This prompted research into development silver-based nanomaterials applications in clinical settings. In this work, synthesis three different nanoparticles (AgNPs) hybrids using both organic inorganic supports with intrinsic properties is described. tuning...
Abstract The catalysed condensation of [60]fullerene with ethyl nitroacetate ( 1b ) or analogous activated nitro derivatives to afford isoxazolino[60]fullerenes has been achieved in both homogeneous and heterogeneous conditions. This direct synthetic approach is more convenient than previous methods. Model reactions electron‐poor dipolarophiles led either isoxazolines conjugate addition products, depending on the compound catalyst. former product was favoured by use Cu II catalytic system....
Abstract Boron dipyrromethene derivates (BODIPYs) are promising photosensitisers (PSs) for cancer treatment using photodynamic therapy (PDT). This study investigates the functionalisation of graphene oxide (GO) with a BODIPY derivate glutathione (GSH) depletion and PDT. The GO 3,5-dichloro-8-(4-boronophenyl) via diol derivatisation phenyl boronic acid moiety at meso position core, allowed to preserve intrinsic properties GO. We demonstrated that both chlorine atoms were substituted by GSH in...
A new synthetic approach for the production of carbon nanomaterials (CNM) decorated with organophosphorus moieties is presented. Three different triphenylphosphine oxide (TPPO) derivatives were used to decorate oxidized multiwalled nanotubes (ox-MWCNTs) and graphene platelets (GPs). The TPPOs chosen bear functional groups able react CNMs by Tour reaction (an amino group), nitrene cycloaddition azido group) or CuAAC (one terminal C–C triple bond). All adducts characterized FTIR, Raman...
The reversibility of the covalent interaction between boronic acids and 1,2- or 1,3-diols has put spotlight on this reaction for its potential in development sensors fishing bioactive glycoconjugates. In work, we describe investigation reversible functionalization surface CdSe/ZnS Quantum Rods (QRs). With mind, have designed a turn-off Förster resonance energy transfer (FRET) system that ensures monitoring extent phenyl residue at meso position BODIPY probe solvent-exposed 1,2-diols QRs’...
Sugar headgroups have been grafted on the surface of graphene oxide (GO) by exploiting vibrational ball mills. The resulting glyco-GO conjugates significantly disrupt an already established P. aeruginosa biofilm.
Hybrid cellulose nanocrystal-gold nanoparticles engineered with sugar headgroups is a functional glyconanomaterial that permits direct visualization of the headgroups-lectins interactions by cryo-transmission electron microscopy.
Mechanochemistry is an emerging and reliable alternative to conventional solution (batch) synthesis of complex molecules under green solvent-free conditions. In this regard, we report here on the conjugation a dextran polysaccharide with fluorescent probe, phenylboronic acid (PBA)-functionalized boron dipyrromethene (BODIPY) applying ball milling approach. The formation esters between PBA BODIPY proved be more efficient in terms reaction time, amount reactants, labelling degree compared...
Abstract The synthesis and reactivity in an [4+2] inverse electron demand hetero Diels‐Alder reaction (ihDA) of original class electron‐poor heterodienes, the N ‐substituted‐1H‐benzo[c][1,2]thiazin‐4‐one‐2,2‐dioxides, are described. These highly reactive electrophiles that allow easy access to unprecedented benzo‐thiazine glyco‐fused derivatives a remarkably selective way, even when using acetylated glycals, previously unexplored within this version ihDA. DFT calculations support...
Oxidized multiwalled carbon nanotubes were modified anchoring phosphine oxides and used as heterogeneous catalysts. A proper substitution of the allowed use Tour reaction nitrene cycloaddition to obtain functionalized (CNT) with a loading up 0.73 mmol/g material. The catalysts proved efficient in Wittig reactions, Mitsunobu Staudinger ligations. Furthermore, phosphorus decorated CNT produce nanocomposite Pd nanoparticles able catalyze Heck reactions.