A5060184265- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Probiotics and Fermented Foods
- Gut microbiota and health
- Plant-Microbe Interactions and Immunity
- Cancer Cells and Metastasis
- Helminth infection and control
- 3D Printing in Biomedical Research
- Viral Infectious Diseases and Gene Expression in Insects
- Bone Metabolism and Diseases
- Mollusks and Parasites Studies
- Animal Genetics and Reproduction
- Insect symbiosis and bacterial influences
- NF-κB Signaling Pathways
- Cytokine Signaling Pathways and Interactions
- bioluminescence and chemiluminescence research
- Plant Pathogens and Resistance
- Entomopathogenic Microorganisms in Pest Control
- Advanced Fluorescence Microscopy Techniques
Roslin Institute
2021-2023
University of Edinburgh
2021-2023
Moredun Research Institute
2021-2023
Vitenparken
2023
University of Aberdeen
2017-2022
Medical Research Council
2018
University of Salford
2014
Fungal cells change shape in response to environmental stimuli, and these morphogenic transitions drive pathogenesis niche adaptation. For example, dimorphic fungi switch between yeast hyphae changing temperature. The basidiomycete Cryptococcus neoformans undergoes an unusual morphogenetic transition the host lung from haploid large, highly polyploid termed Titan cells. influence fungal interaction with cells, including through increased drug resistance, altered cell size, Pathogen...
Gastrointestinal (GI) infections in sheep have significant implications for animal health, welfare and productivity, as well being a source of zoonotic pathogens. Interactions between pathogens epithelial cells at the mucosal surface play key role determining outcome GI infections; however, inaccessibility tract vivo significantly limits ability to study such interactions detail. We therefore developed ovine organoids representing physiologically important gastric intestinal sites infection,...
Abstract The human gut microbiota protects the host from invading pathogens and overgrowth of indigenous opportunistic species via a process called colonization resistance. Here, we investigated antagonistic activity bacteria towards Candida albicans, an fungal pathogen that can cause severe infections in susceptible individuals. Coculture batch incubations C. albicans presence faecal six healthy individuals revealed varying levels inhibitory against albicans. 16S rRNA gene amplicon...
Abstract Fungal morphology significantly impacts the host response. Filamentation and tissue penetration by Candida Aspergillus species are essential for virulence, while growth as a yeast allows thermal dimorphic fungi Coccidiodes, Histoplasma, Talaromyces to reside inside phagocytes disseminate. The basidiomycete Cryptococcus neoformans exhibits an unusual yeast-to-titan transition thought enhance pathogenicity increasing fungal survival in lung dissemination central nervous system. In...
Receptor activator of nuclear factor Kappa-B Ligand (RANKL) is a member the tumour necrosis ligand (TNF) family involved in immune responses and immunomodulation. Expressed various cells types around body, RANKL plays crucial role bone remodelling development thymus, lymph nodes mammary glands. Research other species demonstrates that required for microfold (M cells) gut, however limited information specific to cattle available. Cloning expression bovine (BoRANKL) was carried out bioactivity...
Abstract Fungi undergo changes in cell shape response to environmental stimuli that drive pathogenesis and niche adaptation, such as the yeast-to-hyphal transition of dimorphic fungi changing temperature. The basidiomycete Cryptococcus neoformans undergoes an unusual morphogenetic host lung from haploid yeast large, highly polyploid cells termed Titan cells. influence fungal interaction with cells, including through increased drug resistance, altered size, Pathogen Associated Molecular...
Abstract Gastrointestinal (GI) infections in sheep have significant implications for animal health, welfare and productivity, as well being a source of zoonotic pathogens. Interactions between pathogens epithelial cells at the mucosal surface play key role determining outcome GI infections; however, inaccessibility tract vivo significantly limits ability to study such interactions detail. We therefore developed ovine organoids representing physiologically important gastric intestinal sites...
ABSTRACT The human gut microbiota protects the host from invading pathogens and overgrowth of indigenous opportunistic species via mechanisms such as competition for nutrients by production antimicrobial compounds. Here, we investigated antagonist activity bacteria towards Candida albicans , an fungal pathogen that can cause severe infections mortality in susceptible patients. Co-culture batch incubations C. presence faecal six different healthy individuals revealed varying levels inhibitory...