A5013915659- Cellular Mechanics and Interactions
- 3D Printing in Biomedical Research
- Extracellular vesicles in disease
- Pluripotent Stem Cells Research
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- Cell Image Analysis Techniques
- Hippo pathway signaling and YAP/TAZ
University of California, Davis
2024
Shriners Hospitals for Children - Erie
2024
University of California Davis Medical Center
2024
University of California, Santa Barbara
2021
Biophysical factors play a fundamental role in human embryonic development. Traditional vitro models of organogenesis focused on the biochemical environment and did not consider effects mechanical forces developing tissue. While most tissue has Young’s modulus low kilopascal range, standard cell culture substrate, plasma-treated polystyrene, 3 gigapascals, making it 10,000–100,000 times stiffer than native tissues. Modern approaches attempt to recapitulate biophysical niche organs have...
Understanding how human embryos develop their shape is a fundamental question in physics of life with strong medical implications. However, it challenging to study the dynamics organ formation humans. Animals differ from humans key aspects, and particular development nervous system. Conventional organoids are quantitatively unreproducible exhibit highly variable morphology. Here we present morphologically reproducible scalable approach for studying organogenesis dish, which compatible live...