A5059881939- Natural product bioactivities and synthesis
- Legionella and Acanthamoeba research
- Bioactive Compounds and Antitumor Agents
- Antibiotic Resistance in Bacteria
- Alkaloids: synthesis and pharmacology
- Pharmaceutical and Antibiotic Environmental Impacts
- Enterobacteriaceae and Cronobacter Research
- Erythrocyte Function and Pathophysiology
- Inflammatory mediators and NSAID effects
- Cancer, Lipids, and Metabolism
- Berberine and alkaloids research
- Microbial Metabolism and Applications
- Cancer, Hypoxia, and Metabolism
- Cholinesterase and Neurodegenerative Diseases
- Cancer Mechanisms and Therapy
- Estrogen and related hormone effects
- Biological Activity of Diterpenoids and Biflavonoids
- Sesquiterpenes and Asteraceae Studies
- Plant and Fungal Species Descriptions
- Polysaccharides and Plant Cell Walls
- Cancer-related Molecular Pathways
- Probiotics and Fermented Foods
- Bioactive natural compounds
- Food composition and properties
- Microtubule and mitosis dynamics
Walailak University
2024
Prince of Songkla University
2015-2023
Garcinia mangostana extract (GME) has severe pharmacokinetic deficiencies and is made up of a variety bioactive components.
The increasing prevalence of broad-spectrum ampicillin-resistant and third-generation cephalosporin-resistant Enterobacteriaceae, particularly Escherichia coli Klebsiella pneumoniae, has become a global concern, with its clinical impacts on both human veterinary medicine. This study examined the prevalence, antimicrobial susceptibility, molecular genetic features extended-spectrum β-lactamase (ESBL)-producing E. K. pneumoniae isolates from 10 types raw vegetables.In total, 305 samples were...
Lacticaseibacillus paracasei is one of the probiotic bacteria widely identified from fermented foods. The application L. commonly used in dairy and non-dairy products. To investigate properties cells including their acid, pepsin, pancreatin, bile salt tolerances; adhesion ability; antipathogen activity; antibiotic susceptibility, were incorporated into skim milk lyophilized by freeze drying. Freeze-dried add to green banana powder low moisture additive food matrices a storage analysis...
Breast cancer is the leading cause of female mortality worldwide. Although there are several modern treatments for breast cancer, a high rate recurrence majority treatments; therefore, search effective anticancer agents continues. The present study aimed to investigate anti-breast potential frullanolide, compound which isolated and purified from Grangea maderaspatana plant, selected human cell lines (MCF-7, MDA-MB-468 MDA-MB-231). MTT assay was used assess cytotoxic activity in treatment...
Triple negative breast cancer (TNBC) is a subtype characterized by the absence of estrogen receptor, progesterone receptor and human epidermal growth factor 2 expression. TNBC cells respond poorly to targeted chemotherapies currently in use mortality rate remains high. Therefore, it necessary identify new chemotherapeutic agents for TNBC. In this study, anti-cancer effects 7-α-hydroxyfrullanolide (7HF), derived from Grangea maderaspatana, on MCF-7, MDA-MB-231 MDA-MB-468 were assessed using...
Extended-spectrum β-lactamase (ESBL)-producing Escherichia coli exhibits strong multidrug resistance (MDR) to ampicillin and third-generation cephalosporins. This study examined the occurrence, antimicrobial susceptibility, molecular genetic features of ESBL-producing E. isolates from three commonly consumed minced meat varieties, namely pork, chicken, beef. In total, 150 samples were collected 10 local markets in Thailand. was identified 78 (52%), chicken most contaminated (79.17%). The...
Background: Vatica diospyroides type LS is a known source of valuable compounds for cancer treatment, however, in contrast little about therapeutic efficacy SS. Objective: This study focused on vitro cytotoxicity these fruit extracts, and the cell death mode they induce breast cells. Materials Methods: Acetone extracts were tested against MCF-7 MDA-MB-231 lines. The apoptosis necrosis cells quantified by fluorescence activated sorter (FACS) western blot analyses. Results: After 72 h 50%...
Very strong antiproliferative action of V. diospyroides type SS fruit extracts (IC50 range 1.60-17.45 µg/mL) in MDA-MB-468 cell-line was observed an MTT assay. After dosing extract concentration at half IC50 to cell line for 24 72 hours, treated cells were subjected Annexin V-FITC/PI binding assay, followed by FACS and western blot analyses. Significant apoptotic death with all treatments both exposure times. Dosing acetone pericarp cotyledon induced the highest populations (33 32%, resp.),...
Background Triple-negative breast cancer (TNBC) responds poorly to the available drugs; thus, mortality rate associated with TNBC remains high. 7-α-Hydroxyfrullanolide (7HF) possesses anticancer properties and arrests cells in G2/M-phase via modulation of several proteins involved transition, as well mitotic checkpoint MDA-MB-468 cells. Microtubules (MTs) dynamically regulate cell division G2/M phase are related stress response. However, antimitotic drug cytotoxicity multiple resistance...
Background Acanthamoeba spp. is a waterborne, opportunistic protozoan that can cause amebic keratitis and granulomatous encephalitis. Knema retusa native tree in Malaysia, its extracts possess broad range of biological activities. Niosomes are non-ionic surfactant-based vesicle formations suggest future targeted drug delivery system. Copolymer micelle (poly(ethylene glycol)-block-poly( ɛ -caprolactone); PEG- b -PCL) also key constituent niosome supports high stability efficacy. To establish...
Acanthamoeba, an opportunistic protozoan, exists widely in natural sources and can cause infections humans animals. The absence of effective monotherapy after the initial infection leads to chronic disease recurrence. Tubulin protein is a vital target for design-targeted drug discovery. Anti-tubulin drugs are also used treat Acanthamoeba infections, although resistance these has been observed. Therefore, it necessary identify new targeted infections. this study aimed assess vitro activity...
Kratom (Mitragyna speciosa) leaves are commonly used to enhance endurance and treat diseases. Herein, the effect of fermentation kratom by Lactobacillus rhamnosus was evaluated. Its antibacterial activity investigated against four pathogens: Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), Escherichia coli, E. coli O157:H7. Biofilm inhibition established biofilm eradication assays were also performed. Antioxidant properties determined measuring total phenolic content, flavonoid...