Shanmuga Sundar Saravanabhavan

ORCID: 0000-0003-0598-4187
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Research Areas
  • Graphene and Nanomaterials Applications
  • Legionella and Acanthamoeba research
  • Bone Tissue Engineering Materials
  • Nanoparticle-Based Drug Delivery
  • biodegradable polymer synthesis and properties
  • Nanoparticles: synthesis and applications
  • Gas Sensing Nanomaterials and Sensors
  • Vehicle emissions and performance
  • Advanced Drug Delivery Systems
  • Energy, Environment, and Transportation Policies
  • Medicinal Plants and Neuroprotection
  • Electrospun Nanofibers in Biomedical Applications
  • Membrane Separation Technologies
  • Heme Oxygenase-1 and Carbon Monoxide
  • Solar Thermal and Photovoltaic Systems
  • Building Energy and Comfort Optimization
  • Erythrocyte Function and Pathophysiology
  • Phase Change Materials Research
  • Natural Compound Pharmacology Studies
  • Osteoarthritis Treatment and Mechanisms
  • Biosensors and Analytical Detection
  • Polydiacetylene-based materials and applications
  • Cancer Research and Treatment
  • Tissue Engineering and Regenerative Medicine
  • Advanced oxidation water treatment

Vinayaka Missions University
2023-2025

University of California, Santa Cruz
2025

Indian Council of Medical Research
2024

Institute of Medical Sciences
2024

North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences
2024

Jawaharlal Nehru University
2024

National Institute of Cholera and Enteric Diseases
2024

Aarupadai Veedu Medical College & Hospital
2024

University of Alberta
2024

Anna University, Chennai
2010-2021

Medicinal plants have been used as alternative agents for the treatment of infections. This study aimed to investigate bioactivities medicinal plant extracts including Knema retusa extract (Kre) against Acanthamoeba triangularis T4 in vitro and silico . Anti‐ activities 44 from 5 species were determined. From tested extracts, a chloroform Kre bark showed strongest anti‐ both trophozoites cysts, with MIC values 32.25 62.50 μg/mL, respectively. Then, amebicidal antiadhesion A. investigated....

10.1155/sci5/4311313 article EN cc-by Scientifica 2025-01-01

Here, we present Lancet2, an open-source somatic variant caller designed to improve detection of small variants in short-read sequencing data. Lancet2 introduces significant enhancements, including: 1) Improved discovery and genotyping through partial order multiple sequence alignment assembled haplotype contigs re-alignment sample reads the best supporting allele. 2) Optimized scoring with Explainable Machine Learning models leading better filtering throughout sensitivity scale. 3)...

10.1101/2025.02.18.638852 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2025-02-23

The biosynthesis of nanoparticles using the green route is an effective strategy in nanotechnology that provides a cost-effective and environmentally friendly alternative to physical chemical methods. This study aims prepare aqueous extract Ocimum sanctum ( O. sanctum) -based silver (AgNPs) through test their antibacterial activity. biosynthesized were characterised by colour change, UV spectrometric analysis, FTIR, particle shape size morphology SEM TEM images. are almost spherical oval or...

10.7717/peerj.15590 article EN cc-by PeerJ 2023-07-28

The present study is aimed to evaluate the physiochemical properties and cytotoxicity of mercury-based formulation for development anticancer therapeuticals.The elemental morphological features were characterized by FE-SEM, XPS EDS. described was evaluated its on Hek293 MCF7 cell lines using MTT assay in vitro effects. vivo developmental toxicity also studied zebrafish embryos lethal concentration (LC50) values calculated as per OECD regulations.The characterizations confirmed presence...

10.1371/journal.pone.0195800 article EN cc-by PLoS ONE 2018-04-18

Abstract Natural and synthetic polymeric materials, particularly soft hard tissue replacements, are paramount in medicine. We prepared calcium-incorporated sulfonated polyether-ether ketone (SPEEK) polymer membranes for bone applications. The bioactivity was higher after 21 days of immersion simulated body fluid (SBF) due to calcium concentration the membrane. present a new biomaterial healing system composed polyether ether (Ca-SPEEK) that can function as successful without causing...

10.1042/bsr20232162 article EN cc-by Bioscience Reports 2024-06-01

Introduction An acute gastrointestinal illness outbreak was reported in a higher educational institution among students and faculties East Sikkim, India, from January to February 2023. The investigation conducted identify the source of infection causative pathogens prevent spread outbreak. Methods We defined case as three or more loose stools 24 hours, abdominal pain, vomiting with onset symptoms between 16 16, Active surveillance by reviewing affected individuals at campus patient registers...

10.7759/cureus.64050 article EN Cureus 2024-07-07

The present study focuses on a novel method to integrate the electro-oxidation process with membrane bioreactor reduce biofouling and increase biodegradability index. Here, we used as pretreatment operating at current density of 1.5 mA/cm2 hydraulic retention time six h. mixed liquor suspended solids concentration was maintained constant 3,200 mg/L throughout experiment for 30 days. results obtained were promising percentage removal COD, TOC, total nitrogen, chlorides in range 97%, 90%, 94%,...

10.4491/eer.2020.039 article EN Environmental Engineering Research 2020-09-05

In spite of industries making huge investments, for a viable energy saving, still the methods conservation are lagging and in search alternatives. The major concern that persists with oil gas operations is emission hydrogen sulfide, frequently or inadvertently, during initial later stages process. Hence, this study focuses on indirect electrolysis toward recovery sulfur from sulfide using graphite as both anode cathode calomel reference electrode. recovered was analyzed high-resolution...

10.1080/15567036.2019.1680766 article EN Energy Sources Part A Recovery Utilization and Environmental Effects 2019-11-11

Complicated and large-scale challenge the contemporary biomedical community faces are development of highly-sensitive analytical methods for detection protein markers associated with pathogenic mechanisms [2]. The atomic force microscopy (AFM) method in combination specific fishing is unique among other approaches; it allows visualization counting single molecules [3-6]. present dataset focus on mass spectrometry human hepatitis C virus core antigen (HCV Ag) taking into account potential...

10.1016/j.dib.2019.104240 article EN cc-by Data in Brief 2019-07-08

Background Acanthamoeba spp. is a waterborne, opportunistic protozoan that can cause amebic keratitis and granulomatous encephalitis. Knema retusa native tree in Malaysia, its extracts possess broad range of biological activities. Niosomes are non-ionic surfactant-based vesicle formations suggest future targeted drug delivery system. Copolymer micelle (poly(ethylene glycol)-block-poly( ɛ -caprolactone); PEG- b -PCL) also key constituent niosome supports high stability efficacy. To establish...

10.7717/peerj.18452 article EN cc-by PeerJ 2024-11-15

Keratitis is a serious ocular infection often caused by pathogenic microorganisms such as Acanthamoeba spp. Among other harmful microbes, keratitis presents particular challenge due to its resistance conventional antimicrobial agents. Piper betle Linn., commonly known betel leaf, has been traditionally used for medicinal properties. This study aimed assess the potential of leaf ethanol extract P. Linn. in treatment triangularis monoculture and co-culture with two prevalent bacteria,...

10.14202/vetworld.2024.848-862 article EN cc-by Veterinary World 2024-04-01

Weak clayey soils in construction are considered problematic due to their high compressibility and low bearing capacity. This study proposes an environmentally friendly replacement for conventional soil stabilizers through the use of geopolymer (GP) containing Cashew Nut Shell Ash (CNSA) improve characteristics. In this study, CNSAGP was compared with lime-stabilized unconfined compressive strength (UCS), durability, improved microstructure. The experimental outcomes showed that 9 M + 4%...

10.3390/ceramics7040115 article EN cc-by Ceramics 2024-11-30

Acanthamoeba, an opportunistic protozoan, exists widely in natural sources and can cause infections humans animals. The absence of effective monotherapy after the initial infection leads to chronic disease recurrence. Tubulin protein is a vital target for design-targeted drug discovery. Anti-tubulin drugs are also used treat Acanthamoeba infections, although resistance these has been observed. Therefore, it necessary identify new targeted infections. this study aimed assess vitro activity...

10.14202/vetworld.2024.2829-2845 article EN cc-by Veterinary World 2024-12-01
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