A5001390889- Parasites and Host Interactions
- Research on Leishmaniasis Studies
- Child Nutrition and Water Access
- Parasite Biology and Host Interactions
- Trace Elements in Health
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Alkaline Phosphatase Research Studies
- Enzyme function and inhibition
- Iron Metabolism and Disorders
- Glutathione Transferases and Polymorphisms
- Pneumocystis jirovecii pneumonia detection and treatment
- Parasitic Diseases Research and Treatment
- Helminth infection and control
Fundação Oswaldo Cruz
2013-2024
Institut de Virologie
2017
Centre Hospitalier Universitaire de Tours
2017
Inserm
2017
International Olive Council
2016
Instituto Butantan
2010-2013
Universidade de São Paulo
2013
Abstract Schistosomiasis is caused by parasites of the genus Schistosoma , which infect more than 200 million people. Praziquantel (PZQ) has been main drug for controlling schistosomiasis over four decades, but despite that it ineffective against juvenile worms and size taste issues with its pharmaceutical forms impose challenges treating school-aged children. It also important to note PZQ resistant strains can be generated in laboratory conditions observed field, hence extensive use mass...
Background Schistosomiasis affects more than 200 million individuals worldwide, with a further 650 living at risk of infection, constituting severe health problem in developing countries. Even though an effective treatment exists, it does not prevent re-infection, and the development vaccine still remains most desirable means control for this disease. Methodology/Principal Findings Herein, we report cloning characterization S. mansoni Stomatin-like protein 2 (SmStoLP-2). In silico analysis...
Here we describe the cloning and characterization of Schistosoma mansoni Alkaline Phosphatase (SmAP), previously identified in tegument adult worms. SmAP encodes a complete sequence composed 536 amino acids containing an N-terminal signal peptide, five N-glycosylation sites, GPI anchor signal, similar to that described for mammalian orthologs. Real-time RT-PCR Western blot experiments suggest rapid translation as soon cercariae are transformed into schistosomula. Immunolocalization analysis...
Background It is believed that schistosomes evade complement-mediated killing by expressing regulatory proteins on their surface. Recently, six homologues of human CD59, an important inhibitor the complement system membrane attack complex, were identified in schistosome genome. Therefore, it to investigate whether these molecules could act as CD59-like inhibitors part immune evasion strategy. Methodology/Principal Findings Herein, we describe molecular characterization seven putative...
Schistosomiasis is a debilitating disease caused by flatworm parasites of the Schistosoma genus and remains high public health impact around world, although effective treatment with Praziquantel (PZQ) has been available since 1970s. Control this would be greatly improved development vaccine, which could combined chemotherapy. The sequencing mansoni transcriptome genome identified range potential vaccine antigens. Among these, three nucleotidases from tegument parasite, presumably involved in...
Schistosomiasis, a neglected tropical disease caused by trematodes of the Schistosoma genus, affects over 250 million people around world. This has been associated with learning and memory deficits in children, whereas reduced attention levels, impaired work capacity, cognitive have observed adults. Strongly correlated poverty lack basic sanitary conditions, this chronic endemic infection is common Africa, South America, parts Asia contributes to inhibition social development low quality...
Abstract Schistosomiasis is caused by parasites of the genus Schistosoma , which infect more than 200 million people. While praziquantel (PZQ) has been main drug for controlling schistosomiasis over four decades, PZQ resistant strains have already reported, highlighting need to search new schistosomicidal drugs. S. mansoni survival relies on redox enzyme thioredoxin glutathione reductase ( Sm TGR), a validated target development anti-schistosomal Here we report fragment screening campaign...