A5031725279- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Vibrio bacteria research studies
- HIV/AIDS drug development and treatment
- Vaccine Coverage and Hesitancy
- Alcohol Consumption and Health Effects
- HIV-related health complications and treatments
- Child Nutrition and Water Access
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Hepatitis Viruses Studies and Epidemiology
- Global Maternal and Child Health
- Salmonella and Campylobacter epidemiology
- Primary Care and Health Outcomes
- Aquaculture disease management and microbiota
- Viral gastroenteritis research and epidemiology
- Cassava research and cyanide
- Escherichia coli research studies
- Poxvirus research and outbreaks
- Virology and Viral Diseases
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- Liver Disease and Transplantation
- Travel-related health issues
Emory University
2015-2025
Atlanta VA Health Care System
2021-2025
Centers for Disease Control and Prevention
2010-2024
Atlanta VA Medical Center
2016-2024
Atlanta Medical Center
2016-2024
Veterans Health Administration
2015-2023
University of the West of England
2023
National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention
2023
Medical College of Wisconsin
2022
Rutgers, The State University of New Jersey
2022
Listeria monocytogenes, a bacterial foodborne pathogen, can cause meningitis, bacteremia, and complications during pregnancy. This report summarizes listeriosis outbreaks reported to the Foodborne Disease Outbreak Surveillance System of Centers for Control Prevention 1998-2008. The study period includes advent PulseNet (a national molecular subtyping network outbreak detection) in 1998 Initiative (enhanced surveillance investigation) 2004. Twenty-four confirmed were 1998-2008, resulting 359...
Treatment of hepatitis C virus with potent, interferon-free, direct-acting antiviral regimens no activity against B (HBV) may increase the risk for HBV reactivation in coinfected patients. We present 2 cases during treatment an all-oral regimen simeprevir and sofosbuvir discuss strategies to prevent flare.
Abstract Background Long-acting injectable (LAI) pre-exposure prophylaxis (PrEP) is highly effective at preventing HIV and has the potential to expand PrEP access. Atlanta VA Healthcare System (AVAHCS) one of largest programs within Veteran’s Health Administration (VHA). In mid-2023, we started a LAI program quickly became provider VHA. We aim share our experience building this as well describe uptake amongst patients Methods May 2023, dedicated advanced practice (APP) was hired manage...
Enteropathogenic Escherichia coli (EPEC), enterohemorrhagic E. (EHEC) and enteroaggregative (EAEC) are intestinal pathogens that cause food water-borne disease in humans. Using biochemical methods NMR-based comparative metabolomics conjunction with the nematode Caenorhabditis elegans, we developed a bioassay to identify secreted small molecules produced by these pathogens. We identified indole, indole-3-carboxaldehyde (ICA), indole-3-acetic acid (IAA), as factors only combination sufficient...
To compare the risk of coronavirus disease 2019 (COVID-19) outcomes by antiretroviral therapy (ART) regimens among men with HIV.We included HIV on ART in Veterans Aging Cohort Study who, between February 2020 and October 2021, were 18 years or older had adequate virological control, CD4 + cell count, viral load measured previous 12 months, no COVID-19 diagnosis vaccination.We compared adjusted risks documented severe acute respiratory syndrome 2 (SARS-CoV-2) infection, COVID-19-related...
Current hepatitis C virus (HCV) testing guidance recommends a two-step sequence for diagnosis of HCV infection. Performing an RNA test whenever antibody is reactive (complete testing) critical to achieve national elimination goals. When and no performed, considered incomplete. Historically, approximately one third patients have incomplete testing. This update clarifies that all sites performing screening should ensure single-visit sample collection. approach allows automatic when avoid Use...
Abstract Background Chronic hepatitis C virus (HCV) infection affects >1% of the U.S. population, higher among Veterans. Direct-acting antiviral (DAA) medications are effective for viral cure, termed sustained virologic response (SVR), but repeat viremia after SVR is recognized. Prior work has been limited by use electronic medical record data. We aim to better understand in DAA era through detailed chart review. Methods identified 1,129 individuals from Veteran's Health...
Abstract Background and Aims: Hepatitis C virus (HCV) treatment with direct-acting antivirals (DAA) results in a sustained virologic response (SVR) >90% of individuals (1). Limited prior data describes persons who achieve SVR later develop recurrent viremia. We identify cohort HCV viremia after SVR, detail their risk factors for repeat viremia, describe the time interval to Characteristics Veterans (n= 1129) Methods identified Health Administration care during 2021-2022 received DAAs...
Abstract Background In the Southeastern United States, 2022 mpox outbreak disproportionately impacted people who are black and with HIV (PWH). Methods We analyzed a cohort of 395 individuals diagnosed across 3 health care systems in Atlanta, Georgia between 1 June 7 October 2022. present demographic clinical characteristics use multivariable logistic regression analyses to evaluate association status severe (per US Centers for Disease Control Prevention definition) and, among PWH,...
Abstract During the early weeks of cholera outbreak that began in Haiti October 2010, we conducted a case–control study to identify risk factors. Drinking treated water was strongly protective against illness. Our results highlight effectiveness safe control.
Cartwright, Emily J. MD; Prabhu, Rajesh M. Zinderman, Craig E. MD, MPH; Schobert, William Jensen, Bette MMSc; Noble-Wang, Judith PhD; Church, Kelly Welsh, Cindi; Kuehnert, Matthew Burke, Timothy L. Srinivasan, Arjun the Food and Drug Administration Tissue Safety Team Investigators Author Information
Summary While most human Salmonella infections result from exposure to contaminated foods, an estimated 11% of all are attributed animal exposures, including both direct handling and indirect exposures such as cleaning cages pet food. This report describes the epidemiologic, environmental laboratory investigations conducted in United States part response international outbreak tetracycline‐resistant enterica serotype I 4,[5],12:i:‐ with over 500 illnesses occurring 2008 2010. investigation...
SUMMARY Cameroon has experienced recurrent cholera epidemics with high mortality rates. In September 2009, epidemic was detected in the Far North region of and reported case-fatality rate 12%. We conducted village-, healthcare facility- community-level surveys to investigate reasons for excess mortality. Results this investigation suggest that patients who died were less likely seek care, receive rehydration therapy antibiotics at a facility, tended live further from facilities. Furthermore,...
This study uses machine learning techniques to identify sociodemographic and clinical predictors of progression through the hepatitis C (HCV) cascade care for patients in 1945-1965 birth cohort Southern United States.We compared variables between groups three outcomes: linkage care, initiation antiviral treatment, virologic cure. A decision tree model random forest were built each outcome.Patients primarily male, African American/Black or Caucasian/White, non-Hispanic Latino, insured. The...
Integration of immunizations with hygiene interventions may improve use both interventions. We interviewed 1361 intervention and 1139 comparison caregivers about practices vaccination history, distributed water treatment kits to during infant sessions in clinics for 12 months, conducted a followup survey 2361 1033 caregivers. observed significant increases reported household (30% vs 44%, P < .0001) correct handwashing technique (25% 51%, households no changes households. Immunization...
Direct-acting antiviral (DAA) treatment for hepatitis C virus (HCV) infection is associated with lower mortality and effective in individuals alcohol use disorder (AUD). However, despite recommendations, patients AUD may be less likely to receive DAAs.
Importance Some payers and clinicians require alcohol abstinence to receive direct-acting antiviral (DAA) therapy for chronic hepatitis C virus (HCV) infection. Objective To evaluate whether use at DAA treatment initiation is associated with decreased likelihood of sustained virologic response (SVR). Design, Setting, Participants This retrospective cohort study used electronic health records from the US Department Veterans Affairs (VA), largest integrated national care system that provides...
Estimated hepatitis C prevalence within the Veterans Health Administration is higher than general population and a risk factor for advanced liver disease subsequent complications. We describe care continuum 1 January 2014 to 31 December 2022.
Background. Hygiene interventions reduce child mortality from diarrhea. Vaccination visits provide a platform for delivery of other health services but may overburden nurses. We compared 2 strategies to integrate hygiene with vaccinations in Kenya's Homa Bay district, 1 using community workers support nurses and Methods. was divided into geographical areas, each 9 clinics. Each area randomly assigned either the nurse or community-assisted strategy. At infant vaccination kits were distributed...