A5019838079- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrospinal fluid and hydrocephalus
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- Intracranial Aneurysms: Treatment and Complications
- Meningioma and schwannoma management
- Fetal and Pediatric Neurological Disorders
- Vascular Malformations Diagnosis and Treatment
- Thermal Regulation in Medicine
- Neonatal and fetal brain pathology
- Spinal Dysraphism and Malformations
- Epilepsy research and treatment
- Cardiac Arrest and Resuscitation
- Infectious Diseases and Tuberculosis
- Urological Disorders and Treatments
- Free Radicals and Antioxidants
- Congenital heart defects research
- Bone health and osteoporosis research
- Traumatic Brain Injury Research
- Bone fractures and treatments
- Axon Guidance and Neuronal Signaling
- Spinal Fractures and Fixation Techniques
- Trigeminal Neuralgia and Treatments
- Orthopaedic implants and arthroplasty
- Prostate Cancer Diagnosis and Treatment
Kurume University
2012-2024
National Center of Neurology and Psychiatry
2022-2023
Abstract An important consideration in regeneration therapy is the fact that tissue surrounding an organ supports its function. Understanding structure of periosteum can contribute to more effective bone therapy. As a cellular source, also assists growth and fracture healing; this further necessitates direct contact with bone. However, anchoring strength appears be inexplicably stronger than expected. In study, we used focused ion beam/scanning electron microscope tomography investigate...
Abstract Endocrine and endothelial cells of the anterior pituitary gland frequently make close appositions or contacts, secretory granules each endocrine cell tend to accumulate at perivascular regions, which is generally considered facilitate functions these cells. However, three-dimensional relationships between localization pattern blood vessels are not fully understood. To define characterize spatial relationships, we used scanning electron microscopy (SEM) reconstruction method based on...
Fourth ventricle mass lesion in neurosarcoidosis is very rare and difficult to be diagnosed pathologically. We report a case of progressive hydrocephalus associated with located at the fourth outlet suprasellar region.A 23-year-old man had disturbance consciousness neck stiffness fever. Magnetic resonance imaging revealed diffuse leptomeningeal enhancement, obstructive lesions ventricle. performed an endoscopic biopsy enhanced foramen Magendie, via Monro aqueduct midbrain. Pathologically,...
Abstract Intracranial pressure (ICP) has to be maintained quite constant, because increased ICP caused by cerebrovascular disease and head trauma is fatal. Although controlling clinically critical, only few therapeutic methods are currently available. Barbiturates, a group of sedative‐hypnotic drugs, recognized as secondary treatment for ICP. We proposed novel “step‐down infusion” method, administrating barbiturate (thiamylal) after different time point from the start under normothermia, at...
BACKGROUND AND IMPORTANCE: The long-term outcome of superficial temporal artery (STA)–middle cerebral (MCA) bypass is unclear. We report a very rare case de novo aneurysm after surgery. CLINICAL PRESENTATION: A 57-year-old woman who underwent STA-MCA and internal carotid treatment 14 years earlier developed subarachnoid hemorrhage lobe hematoma on the same side as anastomosis. Angiography showed excellent patency STA ruptured saccular at site remote from Neck clipping evacuation were...
This study aimed to examine the beneficial effects of a novel prophylactic barbiturate therapy, step-down infusion barbiturates, using thiamylal with normothermia (NOR+sdB), on poor outcome in patients severe traumatic brain injuries (sTBI), comparison mild hypothermia (MD-HYPO). From January 2000 March 2019, 4133 TBI were admitted our hospital. The inclusion criteria were: Glasgow coma scale (GCS) score ≤8 admission, age between 20 and 80 years, intracranial hematoma requiring surgical...
Acute subdural hematoma (ASDH) is a serious traumatic disease, and predictive methods for growth are necessary to decide whether emergent operation necessary. This study aimed evaluate the incidence of "leakage" using computed tomography angiography (CTA) in patients with ASDH identify its prognostic value. Sixty-seven were examined CTA (mean age 64.1 ± 20.6 years; 24 men) by analyzing two serial scans (CTA phase delayed phase). We defined positive leakage sign as > 10% increase Hounsfield...
Hematoma expansion (H-Ex) in small-/medium-sized acute epidural hematoma (AEDH) cases upon emergency admission is critical. Predicting H-Ex can lead to early surgical interventions, improving outcomes, and eliminating the need check for via computed tomography (CT). This study aimed identify most reliable predictors of AEDH expansion. We retrospectively collected data from patients with pure not requiring treatment 2012 2022. assessed clinical laboratory data, time injury first CT, follow-up...
OBJECTIVE Hemispherotomy is an effective treatment for intractable hemispheric epilepsy; however, hydrocephalus remains a common complication of the procedure. The causes following hemispherotomy have not been fully elucidated; therefore, purpose this study was to identify risk factors associated with condition. METHODS authors investigated records all patients aged < 18 years who underwent at their institution between 2003 and 2020 were monitored least 1 year after To hydrocephalus,...
Cases involving delayed development of intracranial aneurysms related to gamma knife surgery (GKS) have been recently reported. Here, we present a rare case GKS-induced aneurysm rupture after intravenous injection tissue plasminogen activator (t-PA) for occlusion the middle cerebral artery (MCA). To best our knowledge, this is first in which t-PA-induced GKS-related unruptured aneurysm.A 56-year-old woman underwent GKS left trigeminal neuralgia. Eighteen years later, she suddenly experienced...
BACKGROUND: Corpus callosotomy (CC) is a palliative neurosurgical procedure for patients with intractable epilepsy and without resectable focal epileptogenic lesions. Anterior commissurotomy (AC) has been historically performed CC. However, the efficacy safety of adding AC to CC remain unknown. OBJECTIVE: To describe surgical technique extraventricular retrospectively investigate its clinical by assessing who underwent AC. METHODS: added at our institution since 2018. Fifty-five consecutive...
We examined the clinical characteristics and outcomes of patients who had fallen from ladders statistically analyzed prognostic factors, highlighting impact coexistence head injuries on their prognoses. The records experienced ladder-related falls were admitted to Advanced Emergency Medical Service Center at Kurume University Hospital between April 2013 August 2015 retrospectively reviewed. A total 86 enrolled. mean patient age was 69.2 years, 82 male. median fall height 2.55 m. Sixty fell...
Background: Barbiturate therapy has been widely used to suppress increased intracranial pressure (ICP); however, classical barbiturate disadvantages such as cardiac function depression. This is due lack of detailed pharmacological dynamics and an established safety infusion method.Methods: Two healthy male beagles intubated anesthetized using thiamylal (4·0 mg/kg/h) propofol were maintained for 36 h; one dog was under normothermia the other, hypothermia. A 1·0 mL blood sample collected at 0,...