A5011325165- Synthetic Organic Chemistry Methods
- Phytochemical Studies and Bioactivities
- Marine Sponges and Natural Products
- Asymmetric Synthesis and Catalysis
- Catalytic C–H Functionalization Methods
- Synthesis of Organic Compounds
- Traditional and Medicinal Uses of Annonaceae
- Synthesis and Biological Activity
- Oxidative Organic Chemistry Reactions
- Radical Photochemical Reactions
- Cyclopropane Reaction Mechanisms
- Chemical Synthesis and Reactions
- Advanced Synthetic Organic Chemistry
- Natural product bioactivities and synthesis
- Plant biochemistry and biosynthesis
- Carbohydrate Chemistry and Synthesis
- Bioactive natural compounds
- Fatty Acid Research and Health
- Chemical synthesis and alkaloids
- Catalytic Alkyne Reactions
- Microbial Natural Products and Biosynthesis
- Phytochemicals and Antioxidant Activities
- Antioxidant Activity and Oxidative Stress
- Sesquiterpenes and Asteraceae Studies
- Chemical Synthesis and Analysis
University of Almería
2015-2024
PharmaMar (Spain)
2000-2017
Universidad de Sevilla
2015
Universidad de Granada
1989-2014
University of Leeds
2006
Imperial College London
2006
Universidad Complutense de Madrid
1996
Universidad Nacional Autónoma de México
1984
An efficient new process is described for the synthesis of ecteinascidin ET-743 (1) and phthalascidin (2), starting from readily available cyanosafracin B (3).
Abstract The vast range of reactions mediated by titanocene monochloride (Cp 2 TiCl, the Nugent reagent) in organic synthetic chemistry is reviewed. power reagent demonstrated its ability to promote and/or catalyse several efficient transformations under mild reaction conditions presence functional groups, an environmentally friendly manner and with use simple experimental procedures.
The development of Green Chemistry inevitably involves the green reagents. In this review, we highlight that Cp2TiCl is a reagent widely used in radical and organometallic chemistry, which shows, if not all, at least some 12 principles summarized for Chemistry, such as waste minimization, catalysis, safer solvents, toxicity, energy efficiency, atom economy. Also, complex has proved to be an ideal C–C C–O bond forming reactions, reduction, isomerization, deoxygenation reactions several...
The contents of oxalic acid and calcium in several wild edible plants were analyzed. Oxalic was determined by an espectrophotometric method based on the decrease absorbance at 335 nm due to dissociation zirconium(IV)−chloranilate complex, consecutive addition acid. Calcium atomic absorption spectroscopy. results show absence this two studied plants: hoary cress (Cardaria draba (L.) Desv.) vervain (Verbena officinalis L.). Also noticeable is high content goosefoot (Chenopodium album L.), with...
Abstract 2,3‐Dihydrobenzofurans can be diastereoselectively prepared by condensation of aromatic aldehydes with 2,3‐dihydrobenzoxasilepines under the catalysis Ag I complexes, and in presence a source fluoride ion. The application this strategy using chiral catalysts leads to new enantioselective total synthesis natural cis ‐pterocarpans their trans isomers. Through method, first antifungal agent (−)‐pterocarpin was achieved. In addition, entry into heteroaromatic system...
PM01183 is a new compound that blocks active transcription, produces DNA breaks and apoptosis, affects the inflammatory microenvironment. showed strong antitumor activity in preclinical models of cisplatin-resistant epithelial ovarian cancer.Patients with platinum-resistant/refractory cancer were included two-stage, controlled, randomized (in second stage), multicenter, phase II study. Primary endpoint was overall response rate (ORR) by RECIST and/or GCIG criteria. The exploratory first...
A bioinspired and sustainable procedure for the straightforward synthesis of (±)-aureol has been achieved in eight steps (14% overall yield) from epoxyfarnesol. The key are titanocene(III)-catalyzed radical cascade cyclization an epoxyfarnesol derivative a biosynthetically inspired sequence 1,2-hydride methyl shifts.
In the last two decades, titanocene monochloride has been postulated as a monoelectronic transfer reagent capable of catalyzing an important variety chemical transformations. this Perspective, our contributions to growing field research are summarized and analyzed. Especially known have in C–C bond formation reactions, hydrogen-atom from water radicals, isomerization well development catalytic cycle that subsequently allowed preparation great natural terpenes. It is also worth mentioning...
Analyses of the nutritional composition tender leaves three species Sonchus (S. asper L, S oleraceus L and tenerrimus L) from different locations in south east Spain were carried out. The proximate composition, as well content mineral elements (Na, K, Ca, Mg, P, Fe, Cu, Zn Mn), fatty acids, vitamin C, carotenoids oxalic acid determined. results, which referred to fresh weight, emphasised low proportion available carbohydrates. Vitamin C contents high, ranged 457 mg kg−1 (S tenerrimus) 779...
Abstract Exocyclic allenes constitute useful building blocks in organic synthesis and have recently been identified as key intermediates the of natural products. Here first general method for most straightforward exocyclic reported to date is presented. This based on Barbier‐type cyclization propargyl halides catalyzed by titanium; a safe, abundant, ecofriendly metal. The reaction proceeds under mild conditions compatible with different functional groups provides good yields five‐, six‐,...
The elucidation of the sources n-3 fatty acids available for humans in Upper Palaeolithic and Neolithic is highly relevant order to ascertain availability such nutrients that time frame as well draw useful conclusions about healthy dietary habits present-day humans. To this end, we have analysed fat from several frozen mammals found permafrost Siberia (Russia). A total 6 specimens were included study: 2 mammoths, i.e. baby female calf called "Lyuba" a juvenile "Yuka", both approximately same...
Analyses of the nutritional composition tender leaves three species Sonchus (S. asper L, S oleraceus L and tenerrimus L) from different locations in south east Spain were carried out. The proximate composition, as well content mineral elements (Na, K, Ca, Mg, P, Fe, Cu, Zn Mn), fatty acids, vitamin C, carotenoids oxalic acid determined. results, which referred to fresh weight, emphasised low proportion available carbohydrates. Vitamin C contents high, ranged 457 mg kg−1 (S tenerrimus) 779...
A hindrance no more: The direct asymmetric synthesis of nitrogen heterocycles containing β-quaternary stereocenters, widely found for example in alkaloids, is highly challenging. novel approach shown exploits the desymmetrization prochiral diketo azides to unmask quaternary center, and represents first reported examples aza-Wittig reaction.
The unprecedented homolytic opening of ozonides promoted and catalyzed by titanocene(III) is reported. This novel reaction proceeds at room temperature under neutral, mild conditions compatible with many functional groups provides carbon radicals suitable to form C-C bonds via both homocoupling cross-coupling processes. procedure has been advantageously exploited for the straightforward synthesis natural product brittonin A.
Abstract Kahalalide F (KF) is a novel cyclic depsipeptide anticancer drug, which has shown activity both in vitro and vivo especially against human prostate cancer cell lines. To characterize the pharmacokinetics of KF during phase I clinical trial patients with androgen refractory cancer, method was developed validated for quantitative analysis plasma using high‐performance liquid chromatography (HPLC) coupled to positive electrospray ionization tandem mass spectrometry (ESI‐MS/MS)....