A5070503760- DNA Repair Mechanisms
- Mitochondrial Function and Pathology
- Helicobacter pylori-related gastroenterology studies
- Alzheimer's disease research and treatments
- Electrolyte and hormonal disorders
- Ion Transport and Channel Regulation
- Peptidase Inhibition and Analysis
- Health, Environment, Cognitive Aging
- Aluminum toxicity and tolerance in plants and animals
- Adenosine and Purinergic Signaling
- Genetic factors in colorectal cancer
- Biochemical and Molecular Research
- Single-cell and spatial transcriptomics
- Metabolism and Genetic Disorders
- Carcinogens and Genotoxicity Assessment
- Folate and B Vitamins Research
Oslo University Hospital
2011-2024
University of Oslo
2015-2020
Alzheimer disease (AD) is a devastating neurological associated with progressive loss of mental skills and cognitive physical functions whose etiology not completely understood. Here, our goal was to simultaneously uncover novel known molecular targets in the structured layers hippocampus olfactory bulbs that may contribute early hippocampal synaptic deficits dysfunction AD mice. Spatially resolved transcriptomics used identify high-confidence genes were differentially regulated mice...
The aim of this study was to investigate the relationship between aquaporin (AQP) water channel expression and pathological features early untreated inflammatory bowel disease (IBD) in humans.Patients suspected have IBD on basis predefined symptoms, including abdominal pain, diarrhea, and/or blood stool for more than 10 days, were examined at local hospital. Colonoscopy with biopsies performed samples taken. Patients who did not meet diagnostic criteria displayed no evidence infection or...
Alzheimer's disease (AD) is a progressive, multifactorial neurodegenerative disorder that the main cause of dementia globally. AD associated with increased oxidative stress, resulting from imbalance in production and clearance reactive oxygen species (ROS). ROS can damage DNA other macromolecules, leading to genome instability disrupted cellular functions. Base excision repair (BER) plays major role repairing lesions. Here, we compared expression BER components APE1, OGG1, PARP1 Polβ blood...
Alzheimer's disease (AD) is a of major public health significance, whose pathogenesis strongly linked to the presence fibrillar aggregates amyloid-beta (Aβ) in aging human brain. We exploited transgenic (Tg)-ArcSwe mouse model for AD explore whether oxidative stress and capacity repair DNA damage via base excision (BER) are related Aβ pathology AD. Tg-ArcSwe mice express variants Aβ, accumulating senile plaques at 4–6 months age, develop AD-like neuropathology as adult animals. The relative...
Human macrophages generate antimicrobial reactive nitrogen species in response to infection by Mycobacterium tuberculosis (Mtb). Exposure these redox-reactive compounds induces stress Mtb, which can affect posttranslational modifications (PTM).
One of the main theories aging and neurodegenerative diseases is based on notion that damage in DNA protein accumulates over time, these events could cause many phenotypical changes genome instability seen with process. Oxidative stress induced by reactive oxygen species believed to play a causative role aging, cancer such as Alzheimer's disease (AD). Assemblies amyloid-beta (AB) are suggested be central pathogenesis AD soluble AB have been shown neurotoxic. Transgenic animals expressing...